Bone cancer pain
Original Article Ondansetron attenuates bone cancer pain through the inhibition of Fos in the descending facilitation related nuclei
... Most cancer patients with bone metastasis experience severe ...of pain is limited by our understanding of its underlying ...chronic pain states. We used Walker 256 cell to establish a rat ...
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Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model
... MRMT-1 cancer cells induced pain-related behavior, and the proportion of BDNF-IR-positive neurons were increased significantly in small neurons in the L3 ...rat bone cancer ...
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Negative regulation of REST on NR2B in spinal cord contributes to the development of bone cancer pain in mice
... in bone cancer ...the bone cancer pain go further, the central mechanism is considerably complex and not well ...of bone cancer pain, which was observed with ...
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Original Article Downregulation of PI3Kcb utilizing adenovirus-mediated transfer of siRNA attenuates bone cancer pain
... Abstract: Phosphatidylinositol 3-kinase (PI3K) signaling plays a pivotal role in intracellular signal transduction pathways involved in chronic pain states. PI3K is implicated in pathomechanisms of enhanced ...
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Original Article Inhibitory effects of intrathecal p38β antisense oligonucleotide on bone cancer pain in rats
... p38 family members, p38α and p38β are two of the major isoforms in the mature nervous system. p38α is the most abundant isoform in the DRG and spinal cord [15]. We demonstrated that p38β was mainly expressed in spinal ...
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Effects of Src-kinase inhibition in cancer-induced bone pain
... of bone cancer pain to study the effect of Src inhibition on gait, paw withdrawal latency to heat stimuli, and paw withdrawal thresholds to mech- anical ...mammary cancer cells MRMT-1 (3 10 3 ...
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The history of cancer pain and bone-targeted agents: 10 most commonly asked questions
... widespread bone pain, BTAs may offer additional pain relief to that provided by opioids and radiotherapy or other local/regional analgesic ...of bone cancer pain requires a ...
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Advances in cancer pain from bone metastasis
... Bone cancer pain is a kind of chronic pain with unique and complicated mechanisms, in which the occurrence mecha- nism is always the research hotspot and difficulty to ...rodent bone ...
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WNT signaling underlies the pathogenesis of neuropathic pain in rodents
... and bone cancer. Bone cancer pain is one of the most common symptoms presented by patients with primary bone sarcomas and predominantly occurs as distant metastases of ...
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P2Y<sub>12</sub> receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain
... the cancer group at the 12th day after intrathe- cal injection of MRS2395, with a mild increase in TNF- α ...of bone cancer ...in bone cancer ...in bone cancer ...by ...
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<p>Evaluating the Role of CXCR3 in Pain Modulation: A Literature Review</p>
... and cancer-induced bone pain, which was also associated with a decrease in the analgesic effect of ...dull pain. In a rat model of bone cancer pain, antibody blockade of ...
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Appraisal of pain pattern among patients with bone metastasis on treatment with bisphosphonates and palliative radiotherapy
... Background: Bone is the most common site of metastasis in cancer. Bone metastasis is a devastating condition that can have a negative impact on the lives of patients with advanced cancer in ...
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Evaluation of Quality of Life and Psychological Response in Recurrent and Metastatic Tumors Treated with Palliative Radiotherapy
... were bone metastasis in 51 patients, lymph node metastasis in 7 patients, brain metastasis in 2 patients, local recurrence in 3 patients, and others in 4 patients (Table ...lung cancer was the most frequent ...
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<p>Effect of the Standardized Management of Cancer Pain on Patients with Bone Metastasis of Lung Cancer in China</p>
... with cancer pain and use ...the cancer pain ward and use a double-lock management system to ensure the safe use of ...of cancer pain can have a signi fi cant effect on patients ...
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An investigation into the incidence of pain flare in patients undergoing radiotherapy for symptomatic bone metastases
... test any associations between these variables, with the approximate P-value giving the probability of the observed differences happening by chance. A statistical significance threshold was agreed at 5%. Yates’ continuity ...
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Depression and chronic pain in the elderly: links and management challenges
... of pain. In one study, it was shown that chronic chest pain was independently associated with depression, while pain in other locations such as neck, back or joint pain was ...
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Local Anesthesia With General Anesthesia for Pediatric Bone Marrow Procedures
... procedural pain affects physical recovery (activity and sleep) and social and emotional functioning (Supplemental Fig ...of pain on these ...recorded pain scores and interventions at 6 and 24 hours ...
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Strontium 89 Therapy for Breast Cancer Bone Metastases: Pain Relief Effects and Predictive Factors
... prostate cancer metastasis to the bone, pain relief owing to Sr-89 was observed at about the same rate in cases with 10 or fewer metastases and cases with widespread bone metastases (77%, ...
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I brachytherapy in the palliation of painful bone metastases from lung cancer after failure or rejection of conventional treatments
... The patient, tumor, and brachytherapy characteristics were delineated in Table 1. Patients ranged in age from 25 to 82 years old, with 54 males and 31 females. The histological distribution rate of small cell carcinoma, ...
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<p>Effect of Peritumoral Bupivacaine on Primary and Distal Hyperalgesia in Cancer-Induced Bone Pain</p>
... CIBP-induced primary pressure hyperalgesia was completely blocked by peritumoral bupivacaine at all-time points in the study. This was expected, primarily because bupivacaine, a known local anesthetic, blocks ...
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