Bone metastases
Role of bone anabolic agents in the treatment of breast cancer bone metastases
... cancer bone me- tastasis because they have positive actions on bone in addition to sensitizing tumors to hormonal therapy and ...by bone marrow stromal cells ...decreases bone loss associated ...
9
Prevalence of bone metastases and bone-targeting agent use among solid tumor patients in the United States
... studies, bone metastases were identified by the presence of either an ICD-9-CM diagnosis code of ...with bone metastasis estimated for 2012, as patients previously ineligible for treatment may have ...
11
Cost effectiveness of treatments for the management of bone metastases : a systematic literature review
... Much of the reviewed economic evaluation literature on bone metastases due to prostate cancer focuses on bone-targeted therapies such as denosumab and bisphosphonates, most commonly ZA. In general, ...
31
Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer
... supply, bone is a common site of metastatic spread in NSCLC [13, ...of bone metastases, with 20–30% of NSCLC patients presenting with bone lesions at diagno- sis and an additional 35–40% of ...
9
Management of Painful Bone Metastases: The Interaction between Radiation Therapy and Zoledronate
... of bone metastases, is explained by a cytocidal action de- riving from ionizing tumor cells; this result in reducing mechanical compression and infiltration of bone ...for bone me- tastases is ...
6
Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases
... Abstract: Bone metastases frequently occur in patients with advanced solid tumors, particularly breast and prostate cancers, and nearly all patients with multiple myeloma have some degree of skeletal ...to ...
14
Sclerostin inhibition alleviates breast cancer–induced bone metastases and muscle weakness
... to bone. Bone metastases cause osteolytic lesions that lead to pain, pathologic fractures, and muscle weakness (17, ...reverse bone destruction or improve muscle weakness, demonstrating the ...
18
Can bone scans guide therapy with radium-223 dichloride for prostate cancer bone metastases?
... innumerable bone metastases, three patients had super scans, and five patients had two to seven bone ...the bone scan in both the FR and UR groups are summarized in Figure ...
8
Palliative Radiotherapy for Bone Metastases: An ASTRO Evidence-Based Guideline
... with bone metastases, there is interest to define a subset of patients with a limited number of bone metastases who may achieve more durable pain relief or overall failure-free survival with ...
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Physicians’ preferences for bone metastases treatments in France, Germany and the United Kingdom
... The demographic characteristics of the participating physicians are listed in Table 3. In all three countries, the majority of physicians had been practising medicine for more than 10 years since completing their medical ...
10
Analysis of orthopedic surgery of bone metastases in breast cancer patients
... to bone metastases sur- gery ranged from 0 to 30 years (mean: ...for bone metastases in the first year, 58% in the first 5 years, and 89% in the first 10 ...solitary bone matas- tases ...
5
Utilities associated with subcutaneous injections and intravenous infusions for treatment of patients with bone metastases
... Chemotherapy was associated with a much greater disutil- ity than any of the treatments focused on bone metastases. Of the 121 respondents, 88 (72.7%) differentiated between the health states with and ...
11
Management of bone metastases in refractory prostate cancer – role of denosumab
... for bone metastases; planned palliative radiation or surgery to bone; a life expectancy of less than 6 months; creatinine clearance , 30 mL/min; and current or previous osteonecrosis of the ...to ...
10
Pain in castration-resistant prostate cancer with bone metastases: a qualitative study
... with bone metastases had debili- tating consequences on patients ’ lives with patients reporting impairments in daily functioning from a physi- cal, emotional and social ...of bone pain typically ...
11
Denosumab: a new option in the treatment of bone metastases from urological cancers
... Accumulated evidence suggests that the inhibition of bone resorption is a promising anticancer therapy without severe adverse effects. Until now, zoledronic acid was the only approved agent inhibiting bone ...
9
Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer
... for bone loss and skeletal-related events, including bone meta s- tases, in postmenopausal women with hormone receptor-positive breast ...impact bone, resulting in decreases in bone mineral ...
10
Importance of antiresorptive therapies for patients with bone metastases from solid tumors
... Clinical data indicate that the antiresorptive therapies, zole- dronic acid and denosumab, are generally well tolerated in patients with bone metastases from advanced cancer. It should be noted that ...
11
Health state utilities for skeletal-related events secondary to bone metastases
... or less than the sum of the two disutilities, depending on the individual patient and the unique combination of SREs. Despite the limitations, the current study is a step toward more thorough modeling of treatment for ...
12
Multifocal musculoskeletal tuberculosis mimicking multiple bone metastases: a case report
... Finally, imaging examination is not sensitive for dif- ferentiating multiple bone metastases from multiple musculoskeletal tuberculosis. MRI is more sensitive for the diagnosis of musculoskeletal ...
5
Patterns of practice in palliative radiotherapy for bone metastases in UK centres
... Bone metastases can cause significant morbidity. The management of bone metastases depends upon location as well as patient performance status and previous treatment (1) ...
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