BOVINE PAPILLOMAVIRUS
The Bovine Papillomavirus E5 Protein Requires a Juxtamembrane Negative Charge for Activation of the Platelet-Derived Growth Factor β Receptor and Transformation of C127 Cells
... The bovine papillomavirus E5 gene encodes a 44-amino-acid, homodimeric transmembrane protein that is the smallest known transforming protein. The E5 protein transforms cultured fibroblasts by forming a ...
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Transformation by Bovine Papillomavirus Type 1 E6 Requires Paxillin
... human papillomavirus (HPV) E6 oncopro- teins and E6 from bovine papillomavirus type 1 (BE6) interact with cellular proteins by binding to an eight-amino-acid pep- tide displayed on the target protein ...
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Bovine Papillomavirus Type 13 DNA in Equine Sarcoids
... wide. Bovine papillomavirus types 1 and 2 have typically been associated with sarcoids in ...tify papillomavirus strains, aside from bovine papillomaviruses 1 and 2, which might be associated ...
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Bovine Papillomavirus Type 1: from Clathrin to Caveolin
... endocytosis. Bovine papillomavirus type 1 (BPV1) entry into cells has been shown to occur by clathrin- dependent endocytosis, a pathway that involves the formation of clathrin-coated pits and fusion to ...
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Mutational analysis of the 18-base-pair inverted repeat element at the bovine papillomavirus origin of replication: identification of critical sequences for E1 binding and in vivo replication.
... Replication of bovine papillomavirus requires two viral proteins, E1 and E2-TA. Previously we demonstrated that sequences within an imperfect 18-bp inverted repeat (IR) element were sufficient to confer ...
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Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity.
... These results indicate that the wild-type bovine papillomavirus type 1 genome encodes an E2 repressor protein that moderates the viral transforming activity and allows maintenance of the[r] ...
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Effective Formation of the Segregation-Competent Complex Determines Successful Partitioning of the Bovine Papillomavirus Genome during Cell Division
... the bovine papillomavirus type 1 (BPV1), Epstein-Barr virus (EBV), and Kaposi’s sarcoma-associated human herpesvirus type 8 (KSHV) genomes into daughter cells is mediated by a single viral protein that ...
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Effect of Bovine Papillomavirus E2 Protein-Specific Monoclonal Antibodies on Papillomavirus DNA Replication
... The bovine papillomavirus type 1 (BPV-1) E2 protein is the master regulator of papillomavirus replication and transcription. We have raised a panel of monoclonal antibodies (MAbs) against the BPV-1 ...
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Identification of a Short, Hydrophilic Amino Acid Sequence Critical for Origin Recognition by the Bovine Papillomavirus E1 Protein
... of bovine papillomavirus (BPV) is a site-specific DNA binding protein that recognizes an 18-bp inverted repeat element in the viral origin of ...among papillomavirus E1 ...
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A phosphorylation map of the bovine papillomavirus E1 helicase
... on bovine papillomavirus DNA replication activity, and have pro- vided strong evidence that viral DNA replication is regu- lated by E1 phosphorylation ...
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Bovine Papillomavirus E7 Oncoprotein Inhibits Anoikis
... The bovine papillomavirus type 1 (BPV-1) E7 oncoprotein is required for the full transformation activity of the virus. Although BPV-1 E7 by itself is not sufficient to induce cellular transformation, it ...
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Association of Bovine Papillomavirus E2 Protein with Nuclear Structures In Vivo
... The papillomavirus E2 protein is a central coordinator of viral gene expression, genome replication, and ...of bovine papillomavirus E2 protein in nuclei of proliferating cells and found that E2 is ...
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Competitive binding of viral E2 protein and mammalian core-binding factor to transcriptional control sequences of human papillomavirus type 8 and bovine papillomavirus type 1.
... 1 are negatively regulated by viral E2 proteins via the promoter proximal binding sites P2 and BS1, respec- tively. Mutations of these E2 binding sites can reduce basal promoter activity. This suggests binding of a ...
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Neutralization of bovine papillomavirus by antibodies to L1 and L2 capsid proteins.
... 7570 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest We have generated four mouse monoclonal antibodies MAbs to bovine papillomavirus virions that bound type-specific, a[r] ...
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Replication of bovine papillomavirus type 1 DNA initiates within an E2-responsive enhancer element.
... The patterns detected show that bovine papillomavirus type 1 replicates in these cells bidirectionally and that one replication origin site in the viral genome is utilized.. By employing[r] ...
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Functional Interaction of the Bovine Papillomavirus E2 Transactivation Domain with TFIIB
... 215-410 did not bind in vitro-translated TFIIB or purified FLAG-TFIIB. This may reflect the fact that the conditions we used were not optimum for these reactions. The biological relevance of the E2 DBD binding to TBP and ...
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Structure-Based Mutational Analysis of the Bovine Papillomavirus E1 Helicase Domain Identifies Residues Involved in the Nonspecific DNA Binding Activity Required for Double Trimer Formation
... stitutions at these positions only show modest defects com- pared to wild-type E1 (Fig. 8A). This partial overlap be- tween residues required for DT formation and for DNA helicase activity is consistent with the idea ...
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Localization and analysis of bovine papillomavirus type 1 transforming functions.
... Mutants deleted of the E6 and E7 ORFs located between the HpaI site base 1 and the SmaI site base 945 are still able to induce transformation, albeit at decreased efficiencies, and the B[r] ...
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Promoters of bovine papillomavirus type 1: in vitro activity and utilization.
... RNA 1 p.g of polyadenylated wart RNA, 7.5 pLg of total RNA from cycloheximide-treated ID13 cells, or RNA from a 65-,u in vitro 2537 Downloaded from http://jvi.asm.org/ on November 10, 20[r] ...
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Role of transcriptional repressors in transformation by bovine papillomavirus type 1.
... In this paper, we provide evidence that i this phenotype is not attributable to the absence of other viral genes that overlap the E2 repressor genes, ii the acquisition of transformation[r] ...
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