BRAF mutation
Original Article BRAF mutation in breast cancer by BRAF V600E mutation-specific antibody
... the BRAF mutation status using BRAF V600E mutation specific antibody in human breast cancer tissue, and discuss its clinical ...for BRAF V600E mutation specific antibody was ...
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Original Article Ultrasound features suspicious for malignancy predict the risk of BRAF mutation in papillary thyroid carcinoma
... The BRAF-V600E mutation causes constitutive serine/threonine kinase ...activation. BRAF mutation corre- lates with many aggressive clini- copathological characteristics and poor prognosis in ...
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BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer
... most BRAF mutation-specific methylation changes (Table ...the BRAF wild- type samples were low ...the BRAF mutated samples ...in BRAF wildtype sam- ples compared with normal and ...
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BRAF mutation testing with a rapid, fully integrated molecular diagnostics system
... a BRAF mutation. To determine whether a disease harbors a BRAF mutation, and thus whether treatment with BRAF inhibitors is appropriate, various methods to detect BRAF mutations ...
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Expression of braf mutation in thyroid neoplasms
... This is a rare variant and is composed of tumor cells whose heights are at least three times their widths. Tall cells must be seen in 50% or more of the tumor areas to make a diagnosis of tall cell variant of papillary ...
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Clinical implications of the BRAF mutation in papillary thyroid carcinoma and chronic lymphocytic thyroiditis
... BRAFV600E mutation using specimens obtained after surgery in the Busan Paik Hospital from January 2013 to August ...BRAFV600E mutation, the patient’s age and sex, size of tumor, multiplicity or bila- ...
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Review Article Pleomorphic xanthoastrocytoma inside lateral ventricle: a rare case report and literature review
... Generally, PXA tends to show a relatively good prognosis. Anaplastic PXA or PXA with lepto- meningeal spread or other locations involve- ment may have a worse prognosis [17-19]. Furthermore, patients with gross total ...
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Original Article Langerhans cell histiocytosis in Chinese adults: absence of BRAF mutations and increased FOXP3 regulatory T cells
... [8]. BRAF muta- tion can activate MEK, ERK kinase and trans- mit mitosis signals through MAPK signaling pathways, ultimately leading to tumor forma- ...oncogenic BRAF V600E mutations in the paraffin tissues ...
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... of BRAF muta- tion in diverse settings of colorectal ...of BRAF muta- tions in stage II and stage III disease, where BRAF mutation was an independent prognostic factor indicating worse out- ...
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Shifted termination assay (STA) fragment analysis to detect BRAF V600 mutations in papillary thyroid carcinomas
... of BRAF mutations is the inability to selectively amplify low percentages of variant alleles from a wild-type allele background ...hot-spot BRAF mutation in 159 PTCs and compared the results to those ...
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Sensitive detection of BRAF V600E mutation by Amplification Refractory Mutation System (ARMS)-PCR
... V600E mutation testing has demonstrated util- ity in helping select CRC patients who are considering monoclonal antibody therapy as wild-type BRAF is required for response to anti-EGFR antibodies [9] and ...
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Original Article Association between BRAF and RAS mutations, and RET rearrangements and the clinical features of papillary thyroid cancer
... for BRAF mutation, RAS mutation, and RET rear- rangement ...for BRAF and RAS mutation status, RET rearrangements (posi- tive or negative), and a list of standardized clinicopathologic ...
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The Prognostic Value of Microsatellite Instability, KRAS, BRAF and PIK3CA Mutations in Stage II Colon Cancer Patients
... chemotherapy, BRAF mutation tended to have a neg- ative prognostic effect on survival and also, in contrast to most other reports, MSI tended to be a poor ...
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Concomitant KIT/BRAF and PDGFRA/BRAF mutations are rare events in gastrointestinal stromal tumors
... e.g. BRAF [16]. The BRAF mutation is a rare event in primary ...the BRAF mutation ...(NGS) mutation panels is gaining ground in the clinical diagnostic setting, in the majority ...
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Treating advanced melanoma: current insights and opportunities
... of BRAF mutation it is of great importance not to overlook the abovementioned mutations beside V600E, which account for about one quarter of all mutated ...cases. BRAF mutation, and in part ...
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Dabrafenib in an elderly patient with metastatic melanoma and BRAF V600R mutation: a case report
... the mutation was undetectable during dabrafenib treatment and response, becoming de- tectable before radiologically detected disease progres- ...the BRAF V600R ...to BRAF inhibi- tors, the original ...
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NRAS Q61R, BRAF V600E immunohistochemistry: a concomitant tool for mutation screening in melanomas
... BRAF mutation. These authors, on the other hand, re- ported a case of BRAF V600E mutated melanoma positive on COBAS® but negative on IHC ...and BRAF V600E mutated samples were also reported by ...
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Oncogene mutational analysis in Chinese gastrointestinal stromal tumor patients
... a mutation frequency of 95%. Among these mutation samples, 26 GISTs were found for KIT or PDGFRA mutations, while 12 were KIT/PDGFRA ...(10%), BRAF and ABL1 ...higher BRAF mutation fre- ...
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False negative BRAF V600E mutation results on fine needle aspiration cytology of papillary thyroid carcinoma
... The BRAF V600E mutation results of 221 PTC nodules confirmed as PTC on permanent pathology between De- cember 2011 and June 2013 were retrospectively ...performed BRAF V600E mutation testing ...
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<p>Frequency and clinical features of BRAF mutations among patients with stage III/IV lung adenocarcinoma without EGFR/ALK aberrations</p>
... with BRAF mutations has varied considerably in previous studies, ranging from 9 to 56 ...of BRAF mutation, presence or absence of an EGFR mutation, and the tar- geted therapy ...a BRAF ...
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