Brain barrier
Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF
... the brain because of blood-brain barrier (BBB) efflux transporters so that the brain serves as a reservoir for HIV-1 [2] and a source for viral escape ...the brain can contribute to the ...
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Vitamin C crosses the blood brain barrier in the oxidized form through the glucose transporters
... the brain exceed those in blood by ...blood–brain barrier, and the mechanism of this ...blood–brain barrier in our ...the brain and was retained in the brain tissue in the ...
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Trojan Horse Transit Contributes to Blood Brain Barrier Crossing of a Eukaryotic Pathogen
... blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting the passage of molecules and ...the brain, caus- ing a meningoencephalitis that is estimated to kill over 600,000 ...
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Viral Pathogen Associated Molecular Patterns Regulate Blood Brain Barrier Integrity via Competing Innate Cytokine Signals
... T he central nervous system (CNS) is normally protected from pathogens by the blood-brain barrier (BBB), which is com- posed of brain microvascular endothelial cells (BMECs) joined by tight junctions ...
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The blood brain barrier in neuropsychiatric disorders
... a barrier between substances in the blood and brain and led Lewandowsky to coin the term “blood-brain barrier”, it wasn’t until several years later when Ehrlich’s student Edwin Goldmann ...
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Basement membrane and blood–brain barrier
... blood–brain barrier (BBB) is a highly complex and dynamic structure, mainly composed of brain microvascular endothelial cells, pericytes, astrocytes and the basement membrane ...
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Update on the Role of the Blood-Brain Barrier in Damage to Immature Brain
... Cremer JE, Cunningham VJ, Pardridge WM, et a!: Ki- netics ofblood-brain barrier transport ofpyruvate, lactate and glucose in suckling, weanling and adult rats. Pulsinelli WA, Waldman S, [r] ...
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Blood-brain barrier derangement after electrical brain stimulation
... Noninvasive brain stimulation methods, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation (tDCS), have received considerable attention in recent years for use in the ...
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Entry of Bilirubin into the Brain Due to Opening of the Blood-Brain Barrier
... Serum albumin readily enters the brain following osmotic opening of the blood-brain barrier.25 How- ever, the albumin concentration varies within the brain, and the regional pattern appr[r] ...
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Current concepts of blood brain barrier development
... ABSTRACT Homeostasis of the central nervous system (CNS) microenvironment is essential for its normal function and is maintained by the blood-brain barrier (BBB). The BBB proper is made up of endothelial ...
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Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size
... prevent brain oedema in cerebral ...increased brain oedema and blood-brain barrier (BBB) breakdown, which correlates with worse ...whether brain oedema, BBB injury and inflammation are ...
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Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans
... blood-brain barrier (BBB) ...human brain microvascular endothelial cells (HBMEC) are now available for BBB studies, there are several disadvantages to developing models of the BBB using these ...
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Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma
... of brain cancer and are associated with a poor prognosis, frequent recurrences, and extremely high lethality despite combination treatment of surgery, radiotherapy, and ...blood–brain barrier (BBB) ...
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Disruption of the hippocampal and hypothalamic blood–brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate
... blood–brain barrier (BBB) are associated with cognitive decline ...blood–retinal barrier (BRB) integ- rity in diabetic ...functional barrier, which impedes and reg- ulates the influx of ...
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Super Antibiotics, Part II Hyperforin, Mass Spectroscopy (MS) and Gas Chromatography Mass Spectrometry (GC MS), Evidence of Permeability of the Blood Testis Barrier (BTB) and the Blood Brain Barrier (BBB) to Hyperforin
... blood-testis barrier (BTB) and blood-brain barrier (BBB) to hyperforin and its distribution in other organs of the domestic pig (Sus scrofa domesticus) are ...the brain and testes of ...
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Studying Molecular Aspects of the Blood Brain Barrier Using an in Vitro Model: Contribution of a Global Proteomics Strategy
... A thorough study [12] revealed differences in Triton-X-100-solubilized proteins from bovine BCECs with limited or re-induced BBB functionalities (cultured in the absence or presence of glial cells, respectively). The 81 ...
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Blood-brain Barrier Remodeling during Brain Metastasis Formation
... membrane barrier is achieved though active proteolysis by matrix metalloproteinases (MMPs) ...blood–brain barrier (BBB). Indeed, MMP-9 was found to be overexpressed in brain metastatic lung ...
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What is the blood brain barrier (not)?
... shown to hold true for tissue grafts [5], bacteria [6], viruses [7] and vectors [8], which all evaded immune recognition when delivered to the brain parenchyma. Around the same time as the brain’s “immune ...
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Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
... Abstract: We are now in an aging population, so neurological disorders, particularly the neurodegenerative diseases, are becoming more prevalent in society. As per the epidemiological studies, Europe alone suffers 35% of ...
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A Physiological Barrier Distal to the Anatomic Blood Brain Barrier in a Model of Transvascular Delivery
... the brain homogenate, as in the cap- illary depletion procedure (15), it is unclear wheth- er proteins bound to or trapped by the basal lamina are considered to be in the capillary fraction or the brain ...
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