Brain capillary endothelial cell
Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)
... endotoxin. Endothelial NOS (eNOS) is found in endothelial cells ...the brain, whereas the comparatively large amount of NO generated by iNOS evokes oxidative stress and is clearly neurotoxic to the ...
10
Viral determinants that control the neuropathogenicity of PVC-211 murine leukemia virus in vivo determine brain capillary endothelial cell tropism of the virus in vitro.
... Our results suggest that the 5' half of the SU gp70 coding region of the env gene of PVC-211 MuLV contains the determinants responsible for the induction of pathological changes in the C[r] ...
8
Tumor Necrosis Factor and Reactive Oxygen Species Cooperative Cytotoxicity Is Mediated via Inhibition of NF-κB
... of brain injury precipitate TNF ...after brain injury, act synergistically with TNF in causing cell ...rat brain capillary endothelial cells (RBEC), and corti- cal astrocytes ...
14
Aloe-emodin triggers ROS and Ca 2+ production and decreases the levels of mitochondrial membrane potential of human brain capillary endothelial cells
... hCMEC/D3 cell line was kindly donated by Florence Miller, ...this cell line was carried out in University College Dublin ...Immortalized brain capillary endothelial hCMEC/D3 cell ...
7
In vitro and in vivo studies on gelatin-siloxane nanoparticles conjugated with SynB peptide to increase drug delivery to the brain
... serum-free endothelial cell medium to dif- ferent concentrations (100–600 µ g/mL) and incubated with brain capillary endothelial cells, with cells not exposed to nanoparticles serving ...
11
Intracerebral hemorrhages and syncytium formation induced by endothelial cell infection with a murine leukemia virus.
... Human immunodeficiency virus type 1 has been detected in brain capillary endothelial cells CEC of some AIDS patients 38, and it is postulated that retroviral infection of brain CEC may l[r] ...
10
Transfection of brain capillary endothelial cells in primary culture with defined blood–brain barrier properties
... Cytoplasmic delivery is one of several obstacles in the design of drug carriers. The ultimate challenge could be the entry of genetic material into the nuclear envelope. Molecules smaller than approximately 40 kDa are ...
14
A large-scale electrophoresis- and chromatography-based determination of gene expression profiles in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties
... provided a partial list of non-characterized cytosolic proteins with possible relevance in BBB function. Firstly, many of the identified proteins (27%) are related to metabolic processes, such as the primary metabolism ...
11
Defective endothelial cell migration in the absence of Cdc42 leads to capillary venous malformations
... planar cell polarity (PCP) (Devenport, 2014; Lee and Bautch, ...of cell migration (Kupfer et ...collective cell migration (Vitorino and Meyer, ...vein endothelial cells (Vitorino and Meyer, ...
20
Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain
... apical membrane of the collecting duct [21, 27]. In con- trast, mouse GLUT9 is reportedly expressed both in the apical and basolateral membranes of distal convo- luted tubules of the murine kidney and enterocytes of the ...
10
Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases
... Considering the possibility of insufficient sensitivity of hitherto in-vivo BBB-permeability analysis, we used an in- vitro BBB model with continuous TEER-measurement, known to be a sensitive and reliable method to ...
21
Brain vascular heterogeneity: implications for disease pathogenesis and design of in vitro blood–brain barrier models
... the brain, various in vitro BBB models have been developed, mostly from CEC isolated from GM ...immortalized brain EC lines, such as human derived hCMEC/D3, were developed as alternatives to primary CECs ...
12
Tat peptide-decorated gelatin-siloxane nanoparticles for delivery of CGRP transgene in treatment of cerebral vasospasm
... of cell incubation with the nanocomplexes is long enough for both NP-pLXSN-CGRP complexes to adhere to the cell surface and then internalize into the ...
12
Comparison of apoptosis in human primary pulmonary endothelial cells and a brain microvascular endothelial cell line co cultured with Plasmodium falciparum field isolates
... of action (contact, cytoadherence and/or soluble factors). RBC parasitized-3D7 strain (in vitro maintained culture) and uninfected RBC were used respectively as positive and negative controls for both adherence and ...
10
Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography
... ABCB1, ABCG2 and Na + /K + -ATPase proteins were quantified by the determination of the peptide concen- tration using UHPLC–MS/MS in multiplexed selected reaction monitoring (SRM) method. Each peptide ana- lyzed was ...
10
Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation
... ing cell nuclear antigen (PCNA), CD31, von Willebrand Factor (vWF), vascular endothelial growth factor-a (VEGFa), fibroblast growth factor-1 (FGF-1), platelet derived growth factor-b (PDGFb) and macrophage ...
10
Reduced Vascular Endothelial Growth Factor A Levels are Correlated with the Incidence of Brain Edema in Acute Ischemic Stroke Patients
... causes brain ischemia due to the focal interruption of blood flow to the brain ...The brain ischemia induces tissue hypoxia that can result in brain edema ...of brain edema can also ...
7
Polysialic acid is released by human umbilical vein endothelial cells (HUVEC) in vitro
... In an approach to investigate a biochemical func- tion of polySia, the degradation of polySia by endoN resulted in an increased migration capacity of HUVEC in vitro (Fig. 3b). Since VEGF and bFGF are produced and ...
9
Microphysiological systems and low-cost microfluidic platform with analytics
... Caco-2 cell culture models to two-cell-type and three- cell-type cultures that consist of Caco-2 cells, mucus- producing HT-29 cells, and M-cells ...three- cell-type gastrointestinal tract ...
5
A2A adenosine receptor modulates drug efflux transporter P glycoprotein at the blood brain barrier
... In brain endothelial cells, P-gp is localized in lipid raft, more specifically, in ...the cell membrane upon its encounter with its substrate in the cytoplasm or persists on the cell membrane ...
18