brain microvascular endothelial cells
c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cells
... [20,24]. Thus, activation of MAPKs may be implicated in the expression of inflammatory genes in several mod- els of vascular injury and inflammation [4,51]. Addition- ally, an agonist of GPCR has been found to ...
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Exploring the effects of cell seeding density on the differentiation of human pluripotent stem cells to brain microvascular endothelial cells
... ferentiated and purified using the optimized subcul- ture method. Low-density cultures were excluded from this analysis given their restrictively low BMEC yield. IMR90-4-derived BMECs generated from both medium and high ...
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Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells
... these brain microvascular endothelial cells basally express a range of adhesion molecules commonly expressed by endothelial cells from a variety of tissues (including CD31, CD34, ...
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In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs)
... the brain we stud- ied permeability of 2-PAM in four cell lines: MDCKII, MDCKII-MDR1, MDCKII-FLuc-ABCG2, and BC1- ...epithelial cells (MDCKs) are widely used for in vitro assessment of brain ...
8
Original Article P120 catenin attenuates lipopolysaccharide-induced blood-brain barrier dysfunction and inflammatory responses in human brain microvascular endothelial cells
... Abstract: Increasing evidences suggest that p120 catenin (p120ctn) exerts important functions in the regulation of pro-inflammatory molecules. However, the relationship among p120ctn, inflammatory responses and ...
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Escherichia coli K1 RS218 Interacts with Human Brain Microvascular Endothelial Cells via Type 1 Fimbria Bacteria in the Fimbriated State
... 1 fimbriated bacteria present in the bacterial population at the time of association and invasion assays. Type 1 fimbriae spe- cifically bind mannose, and addition of methyl ␣ - D -mannopy- ranoside decreased the ...
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Lack of intracellular replication of M. tuberculosis and M. bovis BCG caused by delivering bacilli to lysosomes in murine brain microvascular endothelial cells
... Invasion and traversal of the blood-brain barrier (BBB) by Mycobacterium tuberculosis cause meningeal tuberculosis (TB) in the central nervous system (CNS). Meningeal TB is a serious, often fatal disease that ...
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More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells
... Human brain microvascular endothelial cells; HPRT1: Hypoxanthine phosphoribosyltransferase 1; IL: Interleukin; LPS: Lipopolysaccharide; MLKL: Mixed lineage kinase-domain-like; NLRP3: NOD-like ...
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Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells
... for endothelial cells, and the weakly hepatotropic MHV-A59 strain from the murine coronavirus group, we investigated the virus-induced dysfunctions of BBB in vivo and in brain microvascular ...
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Flavin Containing Monooxygenase (FMO) Protein Expression and Its Activity in Rat Brain Microvascular Endothelial Cells
... gene products with different physical properties and sub- strate specificities. Short-chain tertiary amines, such as chlorpromazine and imipramine, are substrates for FMO1, but not FMO2. Chlorpheniramine which has a ...
6
New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis
... BMECs: Brain microvascular endothelial cells; CNS: Central nervous system; CSF: Cerebrospinal fluid; DEPs: Differentially expressed proteins; DMD: Dystrophin; ...
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Anaplasma phagocytophilum-Borrelia burgdorferi Coinfection Enhances Chemokine, Cytokine, and Matrix Metalloprotease Expression by Human Brain Microvascular Endothelial Cells
... human brain microvascular endothelial cells of the blood-brain barrier is facilitated by endothelial cell-derived matrix metalloproteases ...of brain microvascular ...
5
Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics
... Given the lack of understanding of cerebral neosporosis, it is worthwhile to examine the host factors that mediate the complex interplay between N. caninum and the host cell microenvironment at the BBB interface using ...
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The Meningococcal Cysteine Transport System Plays a Crucial Role in Neisseria meningitidis Survival in Human Brain Microvascular Endothelial Cells
... and endothelial cells by endocytosis, the intracellular cysteine con- centration is very low at approximately 100 M ...to endothelial cells comprising the BBB, passes through cells or ...
20
Post mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells
... Several lines of evidence suggest that early diagnosis of GAE due to B. mandrillaris may help successful therapy. This is supported by recent studies of Deetz et al. (2003), who have shown that early initiation of ...
7
Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation
... min. Cells were then permeablized for 1 h in ...serum. Cells were stained for ZO-1 (Life Tech- nologies), claudin-5 (Life Technologies), and DAPI as described previously ...
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Modeling and rescue of defective blood–brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients
... of cells to each other including intracellular attachment between mem- brane regions (gene ontology (GO): 0022610), while Type I interferon-activated signaling (GO: 0060337) and insu- lin-like growth factor ...
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Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells
... not notice a significant decrease in cell density follow- ing hypoxia and OGD stress (two conditions shown to have an impact on the barrier function). Furthermore, we observed a similar outcome when we measured changes ...
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Up-regulation of COX-2/PGE2 by endothelin-1 via MAPK-dependent NF-κB pathway in mouse brain microvascular endothelial cells
... muscle cells, and modulate post-injury responses of these cells in the CNS ...of endothelial cells in neurovascular coupling, which matches adequate supply of cerebral blood flow with the ...
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<p>Effect of the Recombinant Adenovirus-Mediated HIF-1 Alpha on the Expression of VEGF in the Hypoxic Brain Microvascular Endothelial Cells of Rats</p>
... mammalian brain, VEGF expression maintains at a low level to stabilize mature ...vascular endothelial cells, are upregulated under hypoxia conditions to protect brain from insuf fi cient oxygen ...
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