BRCA1 and BRCA2 Genes
The importance of BRCA1 and BRCA2 genes mutations in breast cancer development
... both BRCA1 and BRCA2 ...both BRCA1 and BRCA2 ...of BRCA1 gene primarily (69). This result solely considered BRCA1 gene, but in this review article which considered the results of ...
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Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer
... the BRCA1 and BRCA2 genes in patients with early-onset breast and/or ovarian cancer have not been identified within the Iranian ...the BRCA1 and BRCA2 genes. We analysed ...
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Association of polymorphisms with a family history of cancer and the presence of germline mutations in the BRCA1/BRCA2 genes
... of BRCA1 and BRCA2 of all coding regions was performed for the 204 ...with BRCA1 muta- tions and 21 with a germline pathogenic mutation on BRCA2 gene), 53 had a VUS identified on BRCA1 ...
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Development and validation of a variant detection workflow for BRCA1 and BRCA2 genes and its clinical application based on the Ion Torrent technology
... of BRCA1 and BRCA2 mutation identification are the long genic extension and the clinical interpretation for each of the identified ...ing BRCA1 and BRCA2 mutations, using the Ion Torrent PGM ...
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Hereditary breast and ovarian cancer
... the BRCA1 and BRCA2 genes and most often it appears as syndromes of hereditary breast cancer – site-specific (HBC-ss), hereditary breast-ovarian cancer (HBOC) and hereditary ovarian cancer ...
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Low concentrations of 5-aza-2'-deoxycytidine induce breast cancer stem cell differentiation by triggering tumor suppressor gene expression
... silenced genes, real-time polymerase chain reaction (RT-PCR) was used to detect changes in the expression of p15, p16, p53, PTEN, BRCA1, and BRCA2 genes silenced in BCSCs by hypermethylation ...
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Meeting abstracts from the Annual Conference on Hereditary Cancers 2015
... the BRCA1 (C61G, 4153delA, 5382insC, 185delAG 3875del4, 3819del5, 5370C> T) and BRCA2 (886delGT, 4075delGT, 5972C> T, 6174delT, 8138del5, 5467insT) was detected in 31 patients representing ...the ...
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Association of BRCA1 2Mutation and TP53 Over-Expression with Sporadic vs. Hereditary Iraqi Ovarian Cancer Patients
... detected BRCA1 mutations are a deletion of adenine and guanine [BRCA1 185delAG (exon 2)], and insertion of cytosine [BRCA1 5382insC (exon 20)], and BRCA2 mutation is the deletion of thymine ...
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Germline <em>BRCA1</em> and <em>BRCA2</em> deleterious mutations and variants of unknown clinical significance associated with breast/ovarian cancer: a report from North India
... in BRCA1 and BRCA2 genes that were observed in breast and ovarian cancer patients tested at a tertiary cancer center in North India on high-throughput sequencing platform followed by multiplex ...
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The pathology of familial breast cancer: Immunohistochemistry and molecular analysis
... in BRCA1 and BRCA2 ...for BRCA1 and BRCA2 mutations within high-risk families, the morphological and molecular phenotype may help to identify patients who are suitable for mutation testing of ...
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BRCA Mutation: A Review of Breast Cancer
... the BRCA1 and BRCA2 genes are very different, at least some functions are ...both genes are essential for repairing damaged DNA (see ...steps). BRCA2 binds the single strand DNA and ...
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New recurrent BRCA1/2 mutations in Polish patients with familial breast/ovarian cancer detected by next generation sequencing
... Genomic DNA was extracted from whole blood as de- scribed previously [7]. DNA concentration was deter- mined on a Qubit 2.0 Fluorometer using the Qubit dsDNA BR Assay Kit (Life Technologies). For library preparation, a ...
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Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection
... nal examination and they were grid 3 patients, were selected for molecular genetic testing of BRCA1 and BRCA2 genes. They were referred to the Clinical Oncol- ogy Unit in Medical Research Institute, ...
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BRCA1 and BRCA2 mutations in a population based study of male breast cancer
... 23. Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, Bishop DT, Weber B, Lenoir G, Chang-Claude J, Sobol H, Teare MD, Struewing J, Arason A, Scherneck S, Peto J, Rebbeck TR, Tonin P, Neuhausen S, Barkadottir ...
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Fertility preservation in BRCA mutation carriers—efficacy and safety issues: a review
... and BRCA2 are tumor-suppressor genes located on chromosomes 17q21 and 13q12, respectively [1, ...of BRCA1 gene or BRCA2 gene have been identified. Both BRCA1 gene and BRCA2 gene ...
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Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples
... the BRCA1 and BRCA2 genes by different germline and somatic alterations, and their diagnosis has great significance in targeted tumor therapy, since recently approved PARP inhibitors show high ...
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Poly(ADP-Ribose) Polymerase-1 Inhibition: Preclinical and Clinical Development of Synthetic Lethality
... by BRCA1 and BRCA2 genes have a defect in homologous DNA repair and demonstrate a dependence on alternate DNA repair processes by base excision repair, which requires poly(ADP-ribose) poly- merase 1 ...
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Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis® compared to Genentech's Herceptin®
... the BRCA1 and BRCA2 genes held by Myriad Laboratories have had a detrimental impact on the community we serve ’ ...BRCA genes, it is possible that licensing and business plans would have ...
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Assessing the usefulness of a novel MRI based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study
... Mammographic breast density is usually defined as the pro- portion of a mammographic image occupied by radiodense tis- sue (largely stromal and epithelial tissues, appearing as white regions) as opposed to nondense, ...
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The Pathology of Hereditary Breast Cancer
... the BRCA1 or BRCA2 genes differs morphologically from sporadic breast cancers from age-matched controls ...to BRCA1 or BRCA2 germline ...
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