BRCA1 or BRCA2 (BRCA1/2)
Evidence That BRCA1- or BRCA2-Associated Cancers Are Not Inevitable
... a BRCA1 or BRCA2 gene mutation can cause a deficiency in repairing complex DNA ...containing BRCA1 and BRCA2 gene products are essential to repair spontaneous complex DNA damage or to carry ...
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Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study.
... in BRCA1/BRCA2 mutation carriers and their ...in BRCA1 or BRCA2 , (ii) are noncarriers in families with a pathogenic BRCA1 or BRCA2 mutation, or (iii) are potential carriers but ...
8
BRCA promoter methylation in sporadic versus BRCA germline mutation related breast cancers
... proposed in the literature that BRCA promoter hyperme- thylation takes place almost exclusively in the sporadic setting and only rarely occurs in patients with an under- lying BRCA1 or BRCA2 germline ...
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Mutation analysis of BRCA1/2 mutations with special reference to polymorphic SNPs in Indian breast cancer patients
... for BRCA1 or BRCA2 (35/79: 44.3%). BRCA2 mutations were higher ...than BRCA1 mutations ...of BRCA1 and BRCA2 were higher than those in other exons 2, 3 and 9 polymorphic ...
9
The Pathology of Hereditary Breast Cancer
... with BRCA1 or BRCA2 germline mutations differ in their morphological and immunohistochemical ...with BRCA1 are poorly differentiated infiltrating ductal carcinomas (IDCs) with higher mitotic counts ...
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Assessing the usefulness of a novel MRI based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study
... uninformative BRCA1/2 test result (either clinical or ...a BRCA1 or BRCA2 mutation given her per- sonal and family history of cancer and mutation testing, based on the Boadicea computer ...
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Telomere length shows no association with BRCA1 and BRCA2 mutation status
... of BRCA1 and BRCA2 mutation carriers and ...male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrolment and blood donation, 21 of whom have developed ...
7
Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
... female BRCA1 or BRCA2 pathogenic mutation carriers older than 18 years of age, with the majority recruited through cancer genetics clinics ...(2 BRCA1 and 20 BRCA2) was too small to ...
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Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2for a Defined personal and family history in an Ashkenazi Jewish woman (LAMBDA)
... diagnosis of breast or ovarian cancer and the effects of various extents of family histories, but also on the large Washington study in which the vast majority of women were unaffected and did not have a family history, ...
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Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos
... BC. BRCA2 carriers have a lower risk of ovarian cancer when compared with BRCA1 carriers, but they have a higher risk of prostate, pancreatic, gallbladder, pharyngeal, gastric cancers, melanoma, and a ...
8
Selected aspects of genetic counselling for BRCA1 mutation carriers
... of BRCA1 protein interacts with the Xist RNA in mammalian cells, thereby influencing X chromosome inactivation ...that BRCA1 insufficiency may reduce the ability of Xist RNA to accumulate along the X ...
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Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
... levels; 2) excretion of estrogens and carcinogens from the breast ducts; 3) breast tissue differ- entiation; and 4) a delay in the establishment of regular ovulation and, subsequently, the cumulative number of ...
7
BRCA1 and BRCA2 mutations in a population based study of male breast cancer
... in BRCA1 and ...of BRCA2 mutations in this series could be as high as ...a BRCA1 or BRCA2 mutation carries a different prognosis from breast cancer in men without a ...
5
BRCA1 and BRCA2 mutations in central and southern Italian patients
... and BRCA2 mutations were found in four out of 117 females (3%) and in two out of 19 males ...of BRCA1 and BRCA2 mutations coincided in site-specific female breast cancers (four out of 102; ie 4% ...
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High penetrances of BRCA1 and BRCA2 mutations confirmed in a prospective series
... of BRCA1 and BRCA2 mutations in a prospective ser- ...the BRCA1 or BRCA2 ...rare BRCA1 mutations may be rare because they have lower fitness than the most frequent BRCA1 ...
6
Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
... The large majority of carriers were recruited through cancer genetics clinics offering genetic testing, and enrolled into national or regional studies. Eligibility to participate in CIMBA is restricted to female carriers ...
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The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers
... in BRCA1/2 genes and susceptibility to breast and ovarian ...mutated BRCA1/2 gene ...mutated BRCA1/2 gene will develop breast ...mutated BRCA1/2 gene are five times ...
7
Distinct functions of BRCA1 and BRCA2 in double strand break repair
... Because BRCA1 interacts with a wide range of proteins, it is likely that the protein plays a multifunctional role in DNA ...(Fig. 2). These functions may also require phosphorylation of BRCA1 by the ...
5
BREAST CANCER RISK FACTORS: PREVENTABLE AND NON-PREVENTABLE
... Hereditary non-BRCA1 and non-BRCA2 breast tumors (and even some sporadic carcinomas) are believed to result from the expression of weakly penetrant but highly prevalent mutations in various genes. For ...
5
Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer
... Genomic DNA (40 ng) was amplified using 250 primer pairs (GeneRead DNASeq Targeted panels v2, Qiagen) to target all of the exonic regions as well as the intronic regions within 20-bp of a splicing junction. Amplicons ...
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