BRCA2 MUTATION CARRIERS
Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2mutation carriers
... LCW, ABS and FJC conceived and designed the study. LCW, GC-T, ABS and FJC coordinated the study, and LCW drafted the manuscript. ABS and FJC supervised the analysis and participated in manuscript writing. ZSF and VSP ...
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The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1 and BRCA2 mutation carriers
... for BRCA2) provided no evidence for increased risk associated with these large ...tion carriers (P = 0.6), and 1.12 (0.0.55–2.27) for BRCA2 mutation carriers (P = ...
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Future possibilities in the prevention of breast cancer: Intervention strategies in BRCA1 and BRCA2 mutation carriers
... BRCA1 mutation carriers tends to be of higher grade and to have a higher proportion of atypical medullary cancer and a lower proportion of carcinoma in situ ...[55]. BRCA2 has a lower rate of tubule ...
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Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
... and BRCA2 mutation carriers (EMBRACE) EMBRACE Collaborating Centers are: Coordinating Centre, Cambridge: Steve Ellis, Elena Fineberg, Radka ...
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Parity and breast cancer risk among BRCA1 and BRCA2mutation carriers
... and BRCA2 mutation carriers is that the decision to opt for genetic testing may itself be related to parity, because parous women may be more concerned to be ...unaffected carriers, this will ...
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miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers
... and BRCA2 mutation ...9 BRCA2-associated breast carcinomas were analyzed using ...and BRCA2 mutation carriers (both n = 5) and non-mutation carriers (n = 10) were ...
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Cancer risks for BRCA1 and BRCA2 mutation carriers: Results from prospective analysis of EMBRACE
... Epidemiological study of BRCA1 and BRCA2 mutation carriers (EMBRACE): Douglas F. Easton is the principal investigator of the study. EMBRACE Collaborating Centres are Coordinating Centre, Cambridge: ...
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An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
... and BRCA2 Mutation Carriers (EMBRACE) Collaborating Centers: coordinating center, Cambridge, UK: Debra Frost, Steve Ellis, Elena Fineberg and Radka Platte; North of Scotland Regional Genetics ...
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Common variants at 12p11, 12q24, 9p21, 9q31 2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers
... Epidemiological study of BRCA1 & BRCA2 mutation carriers (EMBRACE) Douglas F. Easton is the PI of the study. EMBRACE Collaborating Centres are: Coordinating Centre, Cambridge: Susan Peock, Debra ...
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Plasma osteoprotegerin and breast cancer risk in BRCA1 and BRCA2 mutation carriers
... BRCA1 mutation carriers who have an increased propensity to develop breast tumours with stem cell-like properties ...BRCA1 mutation carriers exhibit an expanded luminal progenitor ...
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The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
... and BRCA2 mutation carriers (Martin et al, 2003; Tommiska et al, 2005; Copson et al, 2006; Osorio et al, 2006; Wasielewski et al, 2007; Yarden et al, 2008), and some suggested an association between ...
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RAD51 135G>C modifies breast cancer risk among BRCA2 mutation carriers: Results from a combined analysis of 19 studies
... and BRCA2 mutation ...female mutation carriers from 19 studies for the RAD51 135G r C ...and BRCA2 mutation carriers were analyzed separately, the increased risk was ...
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Founder populations and their uses for breast cancer genetics
... unaffected mutation carrier is identified, the question becomes what is the likelihood that she will develop cancer by a given age (age-specific ...and BRCA2 mutation carriers is between 40 ...
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DCIS in BRCA1 and BRCA2 mutation carriers: prevalence, phenotype, and expression of oncodrivers C MET and HER3
... and BRCA2 mutation carriers has focused on surgical options such as risk-reducing bilateral mastectomy and bilateral ...and BRCA2 mutation carriers [31, ...in mutation ...
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Telomere length shows no association with BRCA1 and BRCA2 mutation status
... BRCA1/2 mutation carriers and the largest published study in female BRCA1/2 mutation ...BRCA1/2 mutation status in either of the two ...BRCA1 mutation carriers (n = 45), ...
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Incorporating tumour pathology information into breast cancer risk prediction algorithms
... BRCA1 mutation carriers, 62 BRCA2 mutation carriers and 109 controls from the Breast Cancer Linkage Consortium, and over 300,000 tumours from the general population obtained from the ...
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Effects of BRCA2 cis regulation in normal breast and cancer risk amongst BRCA2 mutation carriers
... that BRCA2 displays DAE in breast and blood samples from healthy individuals ...of BRCA2 , rs144848, as a marker for quantifying allelic transcripts in heterozygous individuals, we observed differences ...
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The pathology of familial breast cancer: Morphological aspects
... to BRCA2, and three were of male breast ...with BRCA2 mutations were different from those arising in patients with BRCA1 ...of BRCA2 tumours with invasive lobular carcinoma, tubular–lobular ...
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Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers
... Figure 4: a. Threshold of γH2AX nuclear intensity damage. We selected the intensity value of 95(arbitrary units) as a cut of to establish the damaging signal intensity because this was the value in where the distribution ...
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Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
... Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC) is supported by the German Cancer Aid (grant 110837 to Rita K. Schmutzler) and by the Center for Molecular Medicine Cologne (CMMC). GEMO: The study was ...
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