Breast cancer stem cell
Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity
... pluripotent stem cells, which exhibit an increased response to leptin including phosphorylation and activation of STAT3 and induction of stem cell markers, as OCT4 and SOX2 ...mesenchymal stem ...
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NQO1 is Required for Beta-lapachone-mediated Downregulation of Breast Cancer Stem Cell Activity
... in cancer development ...induced cell death. Unexpectedly, the cell fractionation experiment and fluorescence microscope analysis showed that SIRT1 localization was not altered by bL treatment even ...
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Keeping an open mind: highlights and controversies of the breast cancer stem cell theory
... resistant cancer cell population and recurrence of a more aggressive form of the ...disease. Cancer cell plasticity presents a clinical challenge, and future research should focus on ...
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Understanding breast cancer stem cell heterogeneity: time to move on to a new research paradigm
... of cancer stem cells (CSCs), which suggests that differ- ent tumors result from different stem cells, and that all cells within a given tumor are capable of progressing to a higher degree of ...
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Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target
... of breast CSCs would be predicted to have shorter cancer-free intervals, poorer overall survival, and a greater incidence of distant metastasis than individuals with breast tumors containing a low ...
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Screening of breast cancer stem cell inhibitors using a protein kinase inhibitor library
... of breast cancer ...of cancer cells, such as ...epithelial cell mark- ers with an overexpression of mesenchymal markers [5, 9, ...of breast cancer ...in breast ...
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Circulating cancer stem cell markers in breast carcinomas: a systematic review protocol
... circulating breast cancer stem cell markers through October 31, 2016, will be searched in PubMed, SCOPUS, Embase, ISI Web of Science, and Google Scholar with no restriction on ...Detecting ...
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Establishment and molecular characterization of breast cancer mesenchymal stem cell line derived from human non metastasis breast cancer tumor
... non-metastasis breast cancer tumor is de- scribed ...the breast cancer cells from breast cancer ...after cell reached to confluency and cryopreserved at different passages ...
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THE ROLE OF SPY1 IN BREAST CANCER STEM/PROGENITOR POPULATIONS: IMPLICATIONS FOR BREAST CANCER TREATMENT
... the breast cancer stem cell and/or progenitor populations, cell surface marker analysis was completed using flow ...specific cell surface marker phenotype for breast ...
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Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment
... to breast cancer ...THP-1 cell line to model monocyte- macrophage differentiation in co-culture with four breast cancer cell lines (MCF7, T47D, MDA-MB-231, MDA-MB-468) to model ...
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Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
... the cancer stem cells, we decided to use mammosphere culture that was first used to isolate and expand mammary stem/pro- genitor cells by Dontu and colleagues [18], based on the ability of ...
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Mesenchymal Stem Cell Therapy for Breast Cancer: Challenges Remaining
... Breast cancer treatment is currently puzzling due to chemoresistance, particularly in some subtypes (like triple negative cancers) and in advanced (metastatic) ...in breast cancer therapy, as ...
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Cancer stem cell metabolism
... In breast cancer, MET CSCs are characterized by high ALDH activity and enhanced proliferative capacity, whereas EMT CSCs are identified by the expression of the CD44 hi /CS24 – surface markers and a ...
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Cancer stem cell metabolism
... In breast cancer, MET CSCs are characterized by high ALDH activity and enhanced proliferative capacity, whereas EMT CSCs are identified by the expression of the CD44 hi /CS24 – surface markers and a ...
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The bone metastasis niche in breast cancer– potential overlap with the haematopoietic stem cell niche in vivo
... injection, breast cancer cells were situated in perivascular sites in the trabecular areas of bone, consistent with the hypothesis that the endosteal and perivascular niche areas broadly overlap in this re- ...
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Natural and synthetic progestins enrich cancer stem cell-like cells in hormone-responsive human breast cancer cell populations in vitro
... All cell culture studies were approved by the University of Missouri Institutional Environmental Health and Safety ...T47-D breast cancer cell lines were obtained from American Type Culture ...
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The stem cell factor antibody enhances the chemotherapeutic effect of adriamycin on chemoresistant breast cancer cells
... ever; breast cancer cells often become resistant to its ...programmed cell death is a phenotypic characteristic of most tumours ...that cancer stem cells (CSCs) are involved in ...
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Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors
... ian cancer cell line SKOV3 ...ovarian cancer cases in HG serous carcinoma and peritoneal metastasis using IHC and found them relevant in disease progression and ...cer cell line was reported ...
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CANCER STEM CELL IN GLIOBLASTOMA MULTIFORME
... Recently, cancer stem cells become a major focus area in cancer ...a cancer cell have the ability of self renewal and differentiation into multiple cell lineages that play the ...
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(A)Symmetric Stem Cell Replication and Cancer
... of cancer research is undergoing a transforma- tion with the recognition that at the root of many tumors is a relatively small group of CSCs that maintains the bulk of the tumor ...including breast ...
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