broad-spectrum antiviral
3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses
... tease exhibits a typical chymotrypsin fold with a Cys...His...Glu catalytic triad; its three-dimensional structure is closely related to that of the 3C pro of rhinovirus 2, as well as to that of poliovirus. The ...
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A broad-spectrum antiviral targeting entry of enveloped viruses
... for antiviral inhibitors. Here, we report on a broad-spectrum antiviral inhibitor that tar- gets the viral lipid membrane, exploiting its lack of biogenic rep- arative capacity to effectuate ...
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Original Article Broad-spectrum antiviral effect of chebulagic acid and punicalagin on respiratory syncytial virus infection in a BALB/c model
... 8. Broad-spectrum antiviral effect of chebulagic acid and punicalagin on IKK-NF-KB in the BALB/c ...model. Broad-spectrum antiviral effect of chebulagic acid and punicalagin on ...
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Predicting broad-spectrum antiviral drugs against RNA viruses using transcriptional responses to exogenous RNA
... with broad-spectrum antiviral activity such as emetine, homoharringtonine, pyrvinium pamoate and anisomycin, indicating that these drugs are potentially active against other RNA ...the ...
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Inhibition of an Aquatic Rhabdovirus Demonstrates Promise of a Broad-Spectrum Antiviral for Use in Aquaculture
... the broad-spectrum antiviral LJ001 for potential use in ...cross-protective antiviral immunity mediated by interferon as well as a long-term, specific adaptive response (17) and is considered ...
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Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase
... a broad-spectrum antiviral agent that has been ap- proved in Japan for the treatment of influenza virus ...unique broad-spectrum antiviral activity of T-705, we explored the role ...
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Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents
... and antiviral drugs are the most powerful tools to combat viral ...However, broad-spectrum antiviral agents (BSAAs, ...expand spectrum of their indications, and identify drug ...
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Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists
... FIG 1 Characterization of novel RIG-I agonists. (A) Schematic representation of 5=pppRNA sequences that include variations of the wild-type (WT) VSV- derived 5=pppRNA (M1 to M8), SELEX-selected RIG-I aptamers, and ...
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The broad spectrum antiviral drug arbidol inhibits foot and mouth disease virus genome replication
... the antiviral potential of ARB against another picornavirus, foot-and-mouth disease virus (FMDV), a member of the genus Aphthovirus and an important veterinary ...
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The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication
... the antiviral potential of ARB against another picornavirus, foot-and-mouth disease virus (FMDV), a member of the genus Aphthovirus and an important veterinary ...
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Arbidol (Umifenovir): A Broad-spectrum Antiviral Drug that Inhibits Medically Important Arthropod-borne Flaviviruses
... antiviral activity arbidol represents a promising candidate for treatment of viral infections in 69.. humans..[r] ...
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Arbidol: a broad spectrum antiviral that inhibits acute and chronic HCV infection
... before antiviral activity is ...inhibited antiviral signaling in FL-Neo and Huh7 cells, an effect which might be attribut- able to ARB disruption of membrane interactions required for signal ...
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Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae
... The antiviral protein griffithsin (GRFT) was originally iso- lated from the red alga Griffithsia ...show broad- spectrum antiviral activity against other viruses, including SARS-CoV ...for ...
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Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue
... Unlike ribavirin, a broad-spectrum antiviral drug that blocks eIF4E activity through a physical mimic of the m7G cap, exhibited mild anti-tumor activity [16, 32], treatment with HHT as a[r] ...
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Modified cyclodextrins as broad-spectrum antivirals
... its broad-spectrum antiviral activity, we evaluated the mechanism of action of CD1 through a time of addition assay using three different viruses (RSV-A, DENV-2, and HSV-2) ...
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In vitro study of biological activity essential Oil of Origanum vulgare L subsp vulgare L
... According to NCCLS, the antibiotic Chloronitromycin used is known to have broad spectrum antifungal activity, antibiotic Sefpotec used is known to have broad spectrum antibacterial activ[r] ...
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Identification of a Broad-Spectrum Arenavirus Entry Inhibitor
... vulnerable antiviral target specific to ...dissimilar antiviral compounds (ST-193, ST-294, and ST- 761) has been mapped to the TMD region of GP2, with over- lapping yet quite distinct patterns of genetic ...
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A Poly N Acetylglucosamine−Shiga Toxin Broad Spectrum Conjugate Vaccine for Shiga Toxin Producing Escherichia coli
... a broad range of patho- gens (25), which might need to be augmented by immunization against a limited number of additional microbial virulence factors such as ...
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Application of Broad-Spectrum Resequencing Microarray for Genotyping Rhabdoviruses
... most diverse viral families described to date, the Rhabdoviridae (ICTVdb, reviewed in reference 7). All of the virus strains tested (except WCBV) were extracted from biological samples and amplified using a nonspecific ...
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CASPOFUNGIN: A NOVEL BROAD-SPECTRUM ANTIFUNGAL AGENT
... a broad spectrum antifungal agent with activity against various fungi including strains of fungi resistant to other antifungal agents and a better tolerability profile, with almost no nephrotoxicity and ...
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