brucei-gambiense
Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria
... Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th ...T. brucei is frequently reported as the causative ...b. gambiense) and ...
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A multicentre, randomised, non inferiority clinical trial comparing a nifurtimox eflornithine combination to standard eflornithine monotherapy for late stage Trypanosoma brucei gambiense human African trypanosomiasis in Uganda
... Trypanosoma brucei gambiense endemic districts of North-Western Uganda to compare the efficacy and safety of NECT (200 mg/kg eflornithine infusions every 12 h for 7 days and 8 hourly oral nifurtimox at 5 ...
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Detection of Group 1 Trypanosoma brucei gambiense by Loop Mediated Isothermal Amplification
... Trypanosoma brucei gambiense is the causative agent of the Gambian form of human African trypanosomiasis (HAT) in sub-Saharan Africa and is responsible for over 90% of all HAT cases ...b. gambiense ...
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INVESTIGATION OF LIVESTOCK FOR PRESENCE OF TRYPANOSOMA BRUCEI GAMBIENSE IN TAFA LOCAL GOVERNMENT AREA OF NIGER STATE, NIGERIA
... Trypanosoma brucei gambiense in livestock to ascertain their reservoir role and also screened for other pathogenic trypanosomes of animals in Tafa Local Government Area of Niger state, ...Trypanosoma ...
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The elimination of Trypanosoma brucei gambiense? Challenges of reservoir hosts and transmission cycles: Expect the unexpected
... b. gambiense-speci fi c PCR and/or immune ...b. gambiense in animals, iii) the stability of gambiense group 1 in non-human hosts and iv) the infectivity of latent animals reservoir hosts infections to ...
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Luminescent multiplex viability assay for Trypanosoma brucei gambiense
... T.b. gambiense strain that was recently iso- lated in the Democratic Republic of the Congo was made bioluminescent by expression of Renilla ...T.b. gambiense sleeping sickness: pentamidine, eflornithine ...
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Blood brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
... Trypanosoma brucei gambiense cross human brain microvascular endothelial cells (BMECs), a human blood-brain barrier (BBB) model system, at much greater efficiency than do ...b. brucei. After noting ...
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Anti-trypanosomal evaluation of Ximenia americana root bark and chromatographic-mass spectrometric profile
... Le et al. [17]. The flavonol has been established to have high radical scavenging capacity, thus anti-trypanosomal activity of X. americana root bark may be attributed possibly to antioxidant activity. Moreover, Maria et ...
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Domestic pigs as potential reservoirs of human and animal trypanosomiasis in Northern Tanzania
... Trypanosoma brucei s. l.; Trypanosoma brucei gambiense, the causative agent of chronic HAT, and ...b. gambiense) led by the World Health Organization (WHO), in- volving many governments and ...
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Invivo Anti Trypanosomal Activity of Aqueous Extractof Azadirachta indica Leaves on Trypanosoma brucei brucei Infected Mice
... Trypanosoma brucei which cause different variants of ...T. brucei gambiense which causes slow onset chronic trypanosomiasis in ...T. brucei rhodesiense which cause fast onset acute ...
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<p>Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds</p>
... brucei (Lister s427-WT) and B48, which was adapted from the clone TbAT1-KO by deletion of the TbAT1 drug transporter, 21 itself derived from s427WT by removal of the TbAT1 gene, 21 by prolonged exposure to ...
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Effects of Diminazene Diaceturate (veriben®) on Serum and Clinico-pathological Changes in Guinea Pigs (Cavia porcellus) Experimentally Infected with Trypanosoma brucei brucei
... The histopathology of the kidneys of Guinea pig (C. porcellus) infected with T. brucei brucei, but not treated showed focal interstitial oedema in the medulla meanwhile, the photomicrograph of the kidney ...
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The detection and treatment of human African trypanosomiasis
... Abstract: Human African trypanosomiasis (HAT) is caused by the injection of Trypanosoma brucei (T. b.) gambiense or T. b. rhodesiense by Glossina, the tsetse fly. Three historical eras followed the ...
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Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
... T. brucei RTPase TbCet1 (11, 12), the N-terminal RTPase domain (amino acids [aa] 1 to 237) of mimivirus capping enzyme (MimiCE) (18), the N-terminal RTPase domain (aa 1 to 236) of AcNPV Lef4 capping enzyme (21), ...
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Trypanosoma brucei RRM1 Is a Nuclear RNA Binding Protein and Modulator of Chromatin Structure
... T. brucei and using microarrays, while our analysis of TbRRM1 was by ...T. brucei, with downregulated genes tending to be proximal to transcription start sites, while upregulated genes are more likely to be ...
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An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeutics
... In conjunction with our commercial partner, MGB Biopharma, we have had great success in developing our MGBs as antibacterials [18] and, crucially, structural features of these MGBs are quite distinct from the diamidines. ...
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Village scale persistence and elimination of gambiense human African trypanosomiasis
... Gambiense human African trypanosomiasis (gHAT) is one of several neglected tropical dis- eases that is targeted for elimination by the World Health Organization. Recent years have seen a substantial decline in the ...
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Estimates of the duration of the early and late stage of gambiense sleeping sickness
... parameters based on substantial datasets, providing esti- mates of the true duration of untreated infections. These parameter estimates are essential pre-requisites to the development of formal approaches for the ...
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In Vitro Generation of Human High-Density-Lipoprotein-Resistant Trypanosoma brucei brucei
... b. brucei 427 (MiTat ...b. brucei 427-800, which was also highly resistant to purified TLF and could grow in media containing 25% normal human se- ...b. brucei 427-800 cells ...b. brucei ...
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Haematological indices in Trypanosoma brucei brucei (Federe isolate) infected Nigerian donkeys (Equus asinus) treated with homidium and isometamidium chloride of ciprofloxacin in broiler chickens after single intravenous and intraingluvial administration
... T. brucei brucei (Federe isolate) developed symptoms of trypanosomosis which included; anaemia, lymphocytosis and ...T. brucei brucei (Federe isolate) with haematological changes which ...
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