BZD: Benzodiazepine
Commentary: Benzodiazepine (BZD) and Related BZD Receptor Agonists: Basic Science Reasons to Limit to Four Weeks or Less
... regarding benzodiazepine efficacy, a perceived lack of alternative treatment op- tions, perception of patient expectations and the doctor-patient relationship (drugs of “convenience”), and an underestimation of ...
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Deprescribing benzodiazepine receptor agonists
... questionnaire, BZD—benzodiazepine, BZRA—benzodiazepine receptor agonist, CBT—cognitive-behavioural therapy, COPD—chronic obstructive pulmonary disease, NNT—number needed to treat, QoE—quality of ...
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Polydrug abuse among opioid maintenance treatment patients is related to inadequate dose of maintenance treatment medicine
... alpha-pyrrolidinovalerophenone; BZD: Benzodiazepine; CYP: Cytochrome P450 enzyme; DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; EMCDDA: European Monitoring Centre for Drugs ...
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In-Silico Docking of Neuroactive Flavones on Benzodiazepine Binding Site of GABA-A Receptor Homology Model
... investigated in a homology model generated in an automated mode. The binding pocket was predicted with Fuzzy oil drop mathematical model. The ligands were docked using PM3 force field method and various ligand-protein ...
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Intervention to reduce benzodiazepine prescriptions in primary care, study protocol of a hybrid type 1 cluster randomised controlled trial: the BENZORED study
... Introduction Benzodiazepines (BZDs) are mainly used to treat anxiety and sleep disorders, and are often prescribed for long durations, even though prescription guidelines recommend short-term use due to the risk of ...
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Purkinje neuron specific down regulation of p38 protects motoric function from the repeated use of benzodiazepine
... with BZD therapy is that patients often experience motor incoordination and movement ...of BZD occurs at a therapeutic dose [12], at an acute and chronic dose, across species [12,13], and across genders, ...
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Long-term Benzodiazepine Treatment in Patients with Psychotic Disorders Attending a Mental Health Service in Rural Greece.
... Long‑term benzodiazepine (BZD) treatment in patients with mental disorders is widespread in clinical practice, and this is also the case of patients with schizophrenia, although the evidence is weak and ...
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Withdrawal induced delirium associated with a benzodiazepine switch: a case report
... to BZD-induced withdra- wal symptoms could be explained by the expression pat- terns of GABA-A pentamers in our patient ’ s brain, because different BZD effects are mediated by different GABA-A pentamers ...
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Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life
... of BZD and therefore have limited clinical ...a BZD compared with placebo (Curran et ...months) BZD users with other groups found BZD consumption over years correlated with impairments in ...
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Benzodiazepine Use and Misuse Among Patients in a Methadone Program
... between BZD-users and non-users in this survey ...differences, BZD users were more likely to be of White or Caucasian race (35% ...non-users, BZD users were more likely to have been prescribed ...
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Long-term benzodiazepine use and salivary cortisol: the Netherlands Study of Depression and Anxiety (NESDA).
... Comorbidity of anxiety and depression as well as anti- depressant use have been found to be associated with salivary cortisol levels in previous research in this study sample, 28 and numbers of antidepressant use and ...
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Benzodiazepine use in COPD: empirical evidence from Norway
... of BZD in COPD, there is still a lack of research on the use of BZD among COPD ...with BZD use. Three relevant indicators of BZD use and consumer behavior were analyzed: 1) the sum of DDD; 2) ...
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First benzodiazepine prescriptions
... PRINCIPALES CONSTATATIONS Les patients avaient demandé «quelque chose» à leur médecin parce qu’ils pensaient être en détresse sérieuse et avaient besoin d’aide. Ils semblaient percevoir un confl it entre la nécessité de ...
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The impact of benzodiazepine use in patients enrolled in opioid agonist therapy in Northern and rural Ontario
... While BZD use in OAT has been studied previously, it has not been studied in a regional context—in this case Northern ...of BZD use and geography on treatment ...
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Efficient one pot synthesis of [1,2,4]triazolo[4,3 α][1,4] benzodiazepines derivatives
... hydrazino1,4- benzodiazepine 1, after the hydrazino 1,4-benzodiazepine 1 had been dissolved, added one equivalent of aldehyde stirred at room temperature for 30 min followed by addition of ...
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Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype
... Here we use four lines of triple GABAAR point-mutated mice, which express only one benzodiazepine-sensitive GABAAR subtype at a time, to show that targeting only a2GABAARs achieves stron[r] ...
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Motivational drive and alprazolam misuse : a recipe for aggression?
... with benzodiazepine use, which further disinhibits the BIS from promoting risk averse avoidance behaviour, aggressive behaviour may ...particularly benzodiazepine-related ...
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Biocatalyzed C-C bond formation for the production of alkaloids
... For instance, the -carboline scaffold is a part of numerous agonists and inverse agonists of benzodiazepine receptor.[28,29,33,34] Benzodiazepine receptors play a pivotal role in the con[r] ...
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Craving for benzodiazepines : the development of the benzodiazepine craving questionnaire
... assess benzodiazepine craving longitudinally and have described its course by means of the ...long-term benzodiazepine users received four repeated measurements of the BCQ, taken over a -month follow-up ...
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Synthesis and Biological Activities of Some Benzodiazepine Derivatives
... the benzodiazepine core tends to exert profound influence in conferring novel biological activities in these ...synthesizing benzodiazepine ring systems have been reported, they continue to receive a great ...
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