c-Cbl
Mutations of c-Cbl in myeloid malignancies
... of c-Cbl to the onset of myeloid malignancies was revealed in mouse ...models. c-Cbl-deficient mice are viable but show lymphoid hyperplasia, enhanced T-cell signaling and primary splenic ...
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H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b
... Since ectopic expression of miR-675 increased migration and proliferation of breast cancer cells in vitro, we examined whether overexpression of miR- 675 could enhance tumor growth and metastasis in vivo by ...
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c-CBL regulates melanoma proliferation, migration, invasion and the FAK-SRC-GRB2 nexus
... In-situ c-CBL expression was quantified using the Nuance multispectral imaging system (Perkin-Elmer, ...for c-CBL detected by ...of c-CBL was also shown in photomicrographs of ...
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Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer
... The great success of EGFR tyrosine kinase inhibitor (TKI) in NSCLC with EGFR activation mutation implies the critical role of EGFR in EGFR mutant NSCLC [22, 23]. The efficacy of EGFR TKI is modest in NSCLC without EGFR ...
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C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6
... c-Cbl comprises a conserved phosphotyrosine-binding domain (PTB), a small zinc-binding domain known as the RING finger domain, a proline-rich region, and multiple tyrosine phosphorylation sites. In ...
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JWA down-regulates HER2 expression via c-Cbl and induces lapatinib resistance in human gastric cancer cells
... Human epidermal growth factor receptor 2 (HER2) targeted therapy is currently considered as the standard treatment for HER2-positive advanced gastric cancer (GC). However, unsatisfactory results of recent phase III ...
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c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors
... SEM. C. c-Cbl regulated the CRC proliferation in a TCF-4 dependent ...or c-Cbl shRNA ...control, c-Cbl silenced cells showed a significant increase in the CRC ...group, ...
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c Cbl–deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action
... Recently, c-Cbl has been suggested to play a novel role in insulin action in adipocytes independent of the PI3K/Akt pathway ...adipocytes, c-Cbl forms a complex with 2 adaptor proteins, APS ...
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The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein.
... The antibodies identified high levels of p100gag-cbI in the residual nuclear fraction of transformed NIH 3T3 cells and lower levels of an 80-kilodalton protein and a 135-kilodalton prote[r] ...
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Polzer, Harald (2013): Aktivierung des FLT3-Signalweges als molekulare Zielstruktur in der akuten myeloischen Leukämie. Dissertation, LMU München: Fakultät für Biologie
... der C-terminale Teil der JM-Domäne eine Interaktion mit beiden Kinasedomänen des assymmetrischen Dimers eingeht und essentiell für die Kinaseaktivierung ist ...ist c-CBL, das mit der PTB-Domäne an ...
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The Cbl family of ubiquitin ligases regulates FcεRI expression and mast cell activation
... by c-Cbl at multiple sites upon antigen stimulation, and provided evidence that this modification controls receptor internalization and sorting along the endocytic compartments through the interaction with ...
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Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation
... or c-Cbl) is a RING ubiquitin ligase that negatively regulates protein tyrosine kinase (PTK) ...potential, Cbl Tyr371 mutants must perturb the LHR-substrate-binding domain interaction and eliminate ...
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conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells
... of CBL expression was shown to accelerate BCR-abl induced myeloid leukemogenesis in a mouse model ...in CBL also exhibit a leukemic disease when the WT CBL gene was deleted ...conditional CBL ...
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Sexual size dimorphism in ground squirrels (Rodentia: Sciuridae: Marmotini) does not correlate with body size and sociality
... skull, CBL, and hind foot length, HFL) were highly correlated with each other across species (Pearson’s product–moment correlation of species means, r > ...on CBL and in only 24% based on HFL (Table ...
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Original Article Reduced miR-9 and miR-181a expression down-regulates Bim concentration and promote osteoclasts survival
... Cell cultures were washed twice with ice-cold PBS and lysed in lysis buffer (20 mM Tris-HCl, pH 7.5, 150 mM NaCl, 1% Triton X-100, 12 mM β-glycerophosphate, 5 mM EGTA, 0.5% deoxy- cholate, 3 mM DTT, 10 mM NaF, 1 mM Na 3 ...
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Mass-Flux Characteristics of Reactive Scalars in the Convective Boundary Layer
... * , corresponding to an effective Damko¨hler number of 0.5. This limiting value is de- termined from a manipulation of the scalar fields of the nonreactive case, and no series of runs with increasing reaction-rate ...
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The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis
... Formalin-fixed paraffin-embedded tumor specimens were collected from the Department of Pathology at the First Hospital of China Medical University. Immunohistochemical staining was performed using the following antibodies: ...
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The evolution of an MCS over southern England. Part 1: Observations
... The observations demonstrate that Line D, already evident as new cells in Figure 15(b) at 1045 UTC, lay well ahead of the cold pool and was not directly associated with it. This line was probably part of a longer line of ...
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Does case-based blended-learning expedite the transfer of declarative knowledge to procedural knowledge in practice?
... E-CBL cases for each subject in which reforms were im- plemented were created using anonymized patient data from the Vienna General Hospital [12]. A novel plug-in for the existing electronic health records (ERH) ...
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Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin dependent enzymes in rats
... inhibition of 70% occurred with 1 h and did not change during the next 48 h. Under these conditions, no inhibition of methylmalonyl-CoA mutase (MMCoAM) was observed. The recovery of MS activity was slow and was only 80% ...
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