C/EBPα
Centipede grass exerts anti adipogenic activity through inhibition of C/EBPβ, C/EBPα, and PPARγ expression and the AKT signaling pathway in 3T3 L1 adipocytes
... ide, 80 μg/ml leupeptin, 3 mM NaF and 1 mM DTT). After cell debris was removed by centrifugation, lysate protein concentrations were determined using Bio-Rad protein Assay Reagent (Bio-Rad Laboratories, USA). Cell ...
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STEM OF Elsholtzia splendens INHIBITS ADIPOCYTE DIFFERENTIATION BY REGULATING PPARγ and C/EBPα GENE EXPRESSION IN 3T3-L1 CELLS
... TG-3’, C/EBPα forward 5’-ATG GAG TCG GCC GAC TTC TAC-3’, reverse 5’-CAG GAA CTC GTC GTT GAA GGC-3’, GAPDH forward 5’-AAC TTT GGC ATT GTG GAA GGG C-3’, reverse 5’-GAC ACA TTG GGG GTA GGA ACA ...
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Targeting CDK1 promotes FLT3 activated acute myeloid leukemia differentiation through C/EBPα
... of C/EBPα (21), and herein we showed that it can also inhibit CDK1 activity (Figure ...of C/EBPα, we cul- tured the cells in the presence of anoth- er compound, PNU 112455A, which inhibits ...
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Keratinocyte growth factor and the transcription factors C/EBPα, C/EBPδ, and SREBP 1c regulate fatty acid synthesis in alveolar type II cells
... of C/EBPα, C/EBPβ, C/EBPδ, SREBP-1, SREBP-2, SCD-1, SCD-2, and fatty acid synthase by in situ hybridization in our cultures, in normal rat lungs, and in lungs from rats that had been instilled ...
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HTLV 1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signaling
... function, C/EBP family proteins have oncogenic properties ...of C/EBPα occurs in cancer, such as B precursor acute lymphoblastic leukemia (ALL) and a subset of human hepatocellular carcinomas (HCCs) ...
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Effects of C/EBPα overexpression on alveolar epithelial type II cell proliferation, apoptosis and surfactant protein-C expression after exposure to hyperoxia
... that C/EBPα is extensively expressed in AEC II, airway epithelial cells, and lung macrophages during the vesicular and alveolar phases of lung development; the abnormal expression of C/EBPα in ...
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Original Article C/EBPα inhibits proliferation of breast cancer cells via a novel pathway of miR-134/CREB
... follows: C/ EBPα (F: 5’-TGG ACA AGA ACA GCA ACG AG-3’, R: 5’-TTG TCA CTG GTC AGC TCC AG-3’), CREB (5’-TCA GCC GGG TAC TAC CAT TC-3’, 5’-TTC AGC AGG CTG TGT AGG AA-3’), Bcl-2 (5’-ATT GTG GCC TTC TTT GAG TTC ...
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Tribbles 1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα
... factor C/EBPα, and Trib1_LSKO mice had increased hepatic C/EBPα ...of C/EBPα in WT mice phenocopied Trib1_LSKO livers, and hepatic knockout of Cebpa in Trib1_LSKO mice revealed ...
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Elimination of C/EBPα through the ubiquitin proteasome system promotes the development of liver cancer in mice
... unknown. C/EBPα is a transcription factor that regu- lates liver ...of C/EBPα at serine 193 (S193-ph) is upregulated in older mice and is thought to contribute to age-associated liver ...of ...
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C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia
... AML, C/EBPα function is frequently disrupted by mutations in its locus or by the action of leukaemogenic fusion proteins [2, 3, ...length C/EBPα, leading to overexpression of the shorter p30 ...
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Protein-x of hepatitis B virus in interaction with CCAAT/enhancer-binding protein α (C/EBPα) - an in silico analysis approach
... (C/EBPa). C/EBPa belongs to the bZip family of transcription factors, which activates transcription of several genes through its binding sites in liver and fat ...The C/EBPa has been shown to bind ...
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Pulikkan, John Anto (2008): Max as a novel co-activator of myeloid transcription factor C/EBPα and the critical role of PIN1 in Acute Myeloid Leukemia with C/EBPα mutation. Dissertation, LMU München: Medizinische Fakultät
... of C/EBP a , silencing of Max should inhibit differentiation induction by ...for C/EBPa alone and/or co-expressed with shRNA against Max, control shRNA, and the cells cultured in media containing ...that ...
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Suppression of C/EBPα expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression
... Because C/EBP ␣ expression was suppressed in periportal hepatoblasts during intrahepatic bile duct development of the wild-type liver (this factor is probably not required for bile duct formation), normal bile ...
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Transcription factor CCAAT/enhancer binding protein alpha up-regulates microRNA let-7a-1 in lung cancer cells by direct binding
... [16]. C/EBPα is required for proper control of adipogenesis, glucose metabolism, granulocytic differ- entiation, and lung ...that C/EBPα indeed acts as a tumor suppressor in a number of tumor ...
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HOX 7 suppresses body weight gain and adipogenesis related gene expression in high fat diet induced obese mice
... is C/EBPα. When C/EBPα responds to a PPARγ stimulus, it cooperates with PPARγ to achieve adi- pocyte ...of C/EBPα is induced by the PPARγ signal, it functions to further ...
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Role and Regulation of CIEBPa in Response to DNA Damage
... block C/EBPα protein induction and are specific to DNA damage response To determine whether GSK3β has a role in C/EBPα induction in response to DNA damage, we treated BALB/MK2 keratinocytes ...
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Anti adipogenic effects of the traditional herbal formula Dohongsamul tang in 3T3 L1 adipocytes
... The mouse fibroblast cell line, 3T3-L1 cells were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA) and Dulbeco’s modified eagle’s medium (DMEM), fetal bovine serum (FBS), newborn calf serum ...
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CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation
... by C/EBPα via an E2F binding site [11] indicates the possibility of a C/ EBPα-mediated transcriptional gene regulation by pro- tein/protein ...whether C/EBPα acts as direct or ...
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Original Article α-Naphthoflavone inhibits 3T3-L1 pre-adipocytes differentiation via modulating p38MAPK signaling
... and C/EBPα expres- sion, which demonstrated that α-NF sup- pressed adipocyte differentiation partially by suppressing the phosphorylation of p38 (Figure ...
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Elevated sensitivity to diet induced obesity and insulin resistance in mice lacking 4E BP1 and 4E BP2
... (C/EBPδ), C/EBPα, and PPARγ coupled with reduced energy expenditure, reduced lipolysis, and greater fatty acid reesterification in the adipose tissue of 4E-BP1 and 4E-BP2 double KO ...
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