C-Jun N-terminal kinase
Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-α and c-Jun N-terminal kinase pathway
... Background: Inflammation plays a crucial role in kidney damage after crush syndrome (CS). Several researchers report that high mobility group box-1 protein (HMGB1) may be the vital trigger in kidney damage, and tumor ...
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Original Article The C-jun N-terminal kinase signaling pathway regulates cyclin D1 and cell cycle progression in airway smooth muscle cell proliferation
... signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K) pathways in ASMC proliferation are well established, the mechanisms by which the c-jun N-terminal kinase ...
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Inhibition of c Jun N terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
... ABSTRACT: Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after rea- ching the metaphase II stage, exposed to further in vitro culture. Aged oocytes remaining at the metaphase II ...
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c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... protein kinase (MAPK) cascades are involved in inflammation and tissue destruc- tion in rheumatoid arthritis ...particular, c-Jun N-terminal kinase (JNK) is highly activated in ...
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c Jun N terminal kinase activation by nitrobenzoxadiazoles leads to late stage autophagy inhibition
... the c-Jun N-terminal kinase (JNK) [2, 3, 13, ...signal-regulating kinase (ASK1), which in turn activates both p38 and JNK mito- gen-activated protein kinase (MAPK) ...
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c Jun N terminal kinase activity supports multiple phases of 3D mammary epithelial acinus formation
... require c-Jun N-terminal kinase (JNK) activity for acinus ...regulated kinase (ERK) phosphorylation, cell proliferation, adhesion-independent cell survival and expression of ...
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Human Endotoxemia Activates p38 MAP Kinase and p42/44 MAP Kinase, But Not c-Jun N-terminal Kinase
... Protein Kinase (MAPK) family are critically involved in intracellular signal trans- duction, mediating cell responses to a variety of dif- ferent infectious and inflammatory ...MAPK, c-jun ...
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Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inhibiting activation of c-Jun N-terminal kinase
... Results: Glossogyne tenuifolia ethanol extract was demonstrated to inhibit T cell activation, not only in the prolifera‑ tion of human PBMCs at the concentrations of 12.5, 25 and 50 μg/mL (P = 0.0118, 0.0030 and 0.0021) ...
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Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain
... spinal nerve ligation (SNL)-induced neuropathic pain [8-10]. Accumulating evidence shows that mitogen- activated protein kinases (MAPKs), activated in spinal glia, play an important role in signaling cascades of ...
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Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats
... The c-jun N-terminal kinase (JNK) is an evolutionarily conserved sub-group of mitogen-activated protein kinases (MAPK) that participates in survival signaling, apoptosis and pain ...
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C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
... While some recent studies have reported a possible association between TDP-43 and TIA-1 [16,17], these have been demonstrated with transfected cells and no clear evidence of endogenous TDP-43-TIA-1 interaction was ...
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Inhibition of c-Jun N-Terminal Kinase Attenuates Low Shear Stress-Induced Atherogenesis in Apolipoprotein E-Deficient Mice
... with normal saline (NS) (n = 42) and JNK inhibitor SP600125 (JNK-I) (n = 42). Perivascular shear stress modifiers were placed around the right carotid arteries, and plaque formation was studied at low shear ...
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Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
... Activated JNK localizes to the nucleus in VZV-infected cells. The location of phosphorylated JNK within the cell determines its access to substrates and potential interacting proteins, both viral and cellular. ...
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c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer
... ethanol series, antigen retrieval was performed by microwave method: slides immersed in 0.01 M citrate buffer (pH 6.0) were placed in microwave oven and microwaved for 15 min (700 W, medium, low, each for 5 min). After ...
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Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway
... and terminal deoxynucleotidyl transferase enzyme mediated dUTP nick-end labeling (TUNEL) staining of testis for spermatogenic cell density, Johnsen’s score and ...
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Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death
... factor c-Jun [35], exacerbated significantly the depres- sor effect and blunted the augmented power density of the LF component of SAP signals during the pro-life phase (Figure 4), without affecting ...
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Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFB1, and IL-6
... relatively high and the number of animals was limited (n = 9), inactivation of JNK2 resulted in a significant elevation of DAI and CDS, whereas there was no significant difference in Mapk8–/– mice, in comparison ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... Figure 7 Inhibition of pJNK improves the structural and functional deficits caused by inhibition of USP14 ’ s DUB activity. (A) Representative immunoblots of pJNK1/2 and JNK1/2 in spinal cords from 5-week-old wild type ...
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Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c Jun N Terminal kinase pathway
... The ASO studies showed that selective MKK7 defi- ciency significantly reduced arthritis severity and joint destruction compared with control ASO-injected group even though MKK7 was only partially depleted. Down- stream ...
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Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9
... Methods: Human umbilical cord – derived MSCs (UC-MSCs) were injected intravenously into 2-octynoic acid coupled to bovine serum albumin (2OA-BSA)-induced autoimmune cholangitis mice. Serum levels of biomarkers and ...
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