c-Jun N-terminal kinase activity
c Jun N terminal kinase activity supports multiple phases of 3D mammary epithelial acinus formation
... JNK activity or expres- sion of dominant negative JNK1 allowed cell engagement to matrix (and b 1-integrin activation), but blocked cell polarisation and so, all subsequent ‘behaviours’ ...JNK activity and ...
14
JIP1 Regulates Axonal Transport of APP and Autophagosomes via Coordination of Kinesin and Dynein Motors
... motor activity by the scaffolding protein JIP1 (c-jun N-terminal kinase- interacting ...motor activity in order to regulate the direction of vesicular transport of various ...
145
Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
... JNK activity, perhaps where viral transcription was ...JNK, c-Jun migrated to the nuclei of infected ...and c-Jun were at basal levels in the cytoplasm of uninfected cells at the plaque ...
14
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
... We examined whether inhibition of JNK also affected localization of TDP-43 in cells exposed to sodium arsenite, the most commonly used SG inducer. Sodium arsenite is also known to induce JNK activation [41]. Initially, ...
22
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... USP14 has an ongoing role in synaptic transmission We observed decreased MEPC frequency, EPC amplitude, and quantal content at the NMJs of TgUsp14CA and ax J mice (Figure 3A-F). Surprisingly, these deficits were mim- ...
18
C Jun N terminal kinases/c Jun and p38 pathways cooperate in ceramide induced neuronal apoptosis
... MAP kinase JNK and p38, subsequent to induction of apoptosis (Wil- laime et ...sphingomyelinase activity is restored, suggesting that ceramide is a central molecule in the apoptotic ...sphingomyelinase ...
11
Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I
... protein kinase/c-Jun N-terminal kinase (SAPK/JNK), p65, DNA methyltransferase 1 (DNMT1) and ...Promoter activity of EZH2 gene was determined using Secrete-Pair Dual ...
13
Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment
... phosphorylated c-Jun N-terminal kinase (p-JNK), and p-tau protein at serine 202 and prevented neurodegeneration of SK-N-MC ...tyrosine kinase receptor type 1 and ...
18
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c Jun N Terminal kinase pathway
... We previously showed that MKK7, but not MKK4, is required for IL-1-induced JNK phosphorylation and AP- 1-driven MMP expression [13]. Nevertheless, MKK4 is a component of the JNK signal complex and is also read- ily ...
9
Dual Role of Jun N-Terminal Kinase Activity in Bone Morphogenetic Protein-Mediated Drosophila Ventral Head Development
... the c-Jun N-terminal kinase pathway but in opposite ...both Jun N-terminal kinase and Dpp activity in peripodial cells causes stronger vibrissae, ...
16
c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer
... mechanisms underlying FOXO1 activation in gastric can- cer is limited. Regarding the association between FOXO1 and JNK, there has been only one study by Ju et al. [22], which showed that JNK induced FOXO1 activation in ...
12
ABL N induced apoptosis in human breast cancer cells is partially mediated by c Jun NH2 terminal kinase activation
... ABL- N treatment and produced a sustained elevation for at least 24 hours in MDA-MB-231 cells, which is much ear- lier than the activation of caspase and the ...phosphorylated c-Jun, which appeared ...
15
Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inhibiting activation of c-Jun N-terminal kinase
... Cytotoxic activity of GTE has been reported in certain cancer cell lines such as HepG2, Hep3B, MDA-MB-231, and MCF-7 [4, 7, 32]. This study showed that the death of cancer cells was mediated through the apoptotic ...
10
Inhibition of c-Jun N-Terminal Kinase Attenuates Low Shear Stress-Induced Atherogenesis in Apolipoprotein E-Deficient Mice
... Many studies have revealed that low shear stress potentiated proinflammatory activation of ECs, and regions of the vas- culature exposed to low shear stress might be susceptible to inflammation be- cause of constitutive ...
10
Jun N terminal kinase maintains tissue integrity during cell rearrangement in the gut
... JNK activity (phosphoJun) is evident in extracts from JNK MO-injected (mosaic) guts, compared with Cont MO-injected gut ...protein kinase C and mCherry (aPKC, green; mCh, red; F-I), E-cadherin and ...
10
c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... DNA-binding activity in synoviocytes, which is prima- rily dependent on new Jun and Fos protein synthesis in synovial ...with c-Jun phosphorylation, the JNK inhibitor reduced MMP1 to baseline ...
10
Inhibition of c Jun N terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
... cytochrome c which, through the activation of Apaf-1, regulates the activity of efector caspase 3, and this results in DNA fragmentation (Budihardjo et ...
11
Stress-responsive gene TauT and acute kidney injury
... by c-Jun. Two potential binding sites for c-Jun were identified in the promoter region of ...of c-Jun N-terminal kinase (JNK) enhanced TauT promoter ...by ...
8
Human Endotoxemia Activates p38 MAP Kinase and p42/44 MAP Kinase, But Not c-Jun N-terminal Kinase
... This consideration prompted us to assay activa- tion of the three major MAPK family members in a well-established model of systemic inflammation in human, human endotoxemia (10). Both phosphoryla- tion and in vitro ...
6
c Jun N terminal kinase activation by nitrobenzoxadiazoles leads to late stage autophagy inhibition
... specific kinase inhibitors, we previously reported that in U-2OS cells NBDHEX causes a p38-dependent arrest in the G2/M phase followed by JNK-dependent apoptosis ...caspase-3 activity was dramatically ...
12