c-Jun N-terminal kinase pathway
Neuroprotection by inhibiting the c-Jun N-terminal kinase pathway after cerebral ischemia occurs independently of interleukin-6 and keratinocyte-derived chemokine (KC/CXCL1) secretion
... concentrations were not influenced by the treatment (Figure 1B). The 24 h time point was not tested in MCAO+D-JNKI1 mice as no significant difference was found between sham and MCAO+vehicle (not shown). Overall, we did ...
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Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
... Tracking the induction of JNK by confocal microscopy pro- vided an approach to studying the kinetics of JNK activation that did not depend on a high MOI. Analysis of phospho-JNK at the edges of plaques, where infection ...
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Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway
... and terminal deoxynucleotidyl transferase enzyme mediated dUTP nick-end labeling (TUNEL) staining of testis for spermatogenic cell density, Johnsen’s score and ...
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Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c Jun N Terminal kinase pathway
... The ASO studies showed that selective MKK7 defi- ciency significantly reduced arthritis severity and joint destruction compared with control ASO-injected group even though MKK7 was only partially depleted. Down- stream ...
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Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats
... such as TNF-α, IL-1β and IL-6. It has been well accepted that after nerve injury, levels of proinflammatory cytokines increased in the spinal cord and became the primary activa- tors of the JNK pathway [4,28,29]. ...
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c Jun N terminal kinase activation by nitrobenzoxadiazoles leads to late stage autophagy inhibition
... U-2OS, MM-B1 and MCF-7 cells are quite similar, while the extent of autophagy inhibition observed in the latter two cell lines appears much lower as compared to that of U-2OS. On the other hand, this apparent lack of ...
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c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... either JNK1 or JNK3 in RA synoviocytes (9). SP600125 further decreased MMP expression in the knockout syn- oviocytes, suggesting that blockade of both JNKs is needed for complete inhibition of MMP production. This is ...
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MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
... protein kinase (MAPK), which subsequently induce sev- eral cellular responses including gene expression and pulmonary fibrosis [14, ...the c-Jun N-terminal kinase (JNK) signaling ...
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Flavonoids in modulation of cell survival signalling pathways
... ERK, c-Jun N-terminal kinase (JNK), and p38, MAPKs (Johnson and Lapadat ...signalling pathway, also known as the p42/p44 MAPK pathway, is a major determinant of cell ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... protein kinase kinase 4 (MKK4), which, in turn, phosphorylates ...cause terminal swelling [32] and sprout- ing [33] at the NMJ that is similar to what we observed in the TgUsp14CA mice (Figure 3H), ...
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Original Article Puerarin modulates autophagy to ameliorate cerebral ischemia/reperfusion injury through JNK signaling pathway
... protein kinase (AMPK)-mam- malian target of rapamycin (mTOR) [15, 16], and the c-Jun N-terminal kinase (JNK) signaling pathway [17] could modulate activation of au- ...
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Inhibition of c Jun N terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
... apoptotic pathway regulation is c-Jun-N-terminal kinase (JNK), stress kinase from the mitogene-activated protein kinase (MAPK) ...
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c Jun N terminal kinase activity supports multiple phases of 3D mammary epithelial acinus formation
... signalling pathway inhibitor PD98059 are resistant to the effects of JNK ...MEK-ERK pathway inhibitor, PD98059, added at the time of cell seeding, protected from inhibition of lumen clearance (as judged by ...
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C Jun N terminal kinases/c Jun and p38 pathways cooperate in ceramide induced neuronal apoptosis
... JNK pathway activation in these cells. Western blot analyses of JNK and c-Jun using phospho-specific antibodies reveal that JNK and subsequent c-Jun phosphorylation occur hours before ...
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Original Article The C-jun N-terminal kinase signaling pathway regulates cyclin D1 and cell cycle progression in airway smooth muscle cell proliferation
... JNK, C-jun N-terminal kinase; NF-κB, Nuclear factor-kappa B; PI3K, Phosphoinosi- tide 3 kinase; ERK, Extracellular signal-regulat- ed kinase; MAPK, Mitogen activated ...
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Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer
... Human breast cancer tissue array (catalog number BR8015) was purchased from US Biomax (Rockville, MD). The tumor samples included 58 invasive ductal carcinoma, 8 medullary carcinoma and 4 ductal-lobular mixed carcinoma ...
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Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer
... to kinase inhibitors remain a major clinical challenge in the treatment of ...emerging kinase inhibitor resistance ...a kinase inhibitor shows promising potential in cases of therapy ...
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Differential roles of p38 MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart
... this kinase, which were maximal at 1 h ...substrate c-Jun was similarly found to be phosphorylated with maximal values attained at 3 h of perfusion at 42°C ...and c-Jun in ...
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TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
... ampal neuronal development as TNF-deficient mice display accelerated maturation of the dentate gyrus region and smaller dendritic trees in the hippocampus [61]. In contrast, TNF can potentiate excitotoxicity by two ...
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Jun N terminal kinase maintains tissue integrity during cell rearrangement in the gut
... protein kinase C and mCherry (aPKC, green; mCh, red; F-I), E-cadherin and laminin (Ecad, green; lam, red; J-M), and integrin-β1 (Int, green, to delineate cell outlines; N-Q) in the ...
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