c-Jun N-terminal kinases
C Jun N terminal kinases/c Jun and p38 pathways cooperate in ceramide induced neuronal apoptosis
... (MAP), c- Jun N-terminal kinases (JNK) and p38 are important reg- ulators of the cell death program in post-mitotic neurons following survival-factor withdrawal (Mielke and Herdegen, ...
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Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors
... dependent kinase inhibitor p21 WAF1 [10] that is up- regulated at (and can induce) cellular senescence [11]. In addition, expression of a constitutively active MKK7 (a JNK1/2 kinase) leads to inhibition of cell ...
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Epstein-Barr Virus Immediate-Early Proteins BZLF1 and BRLF1 Activate the ATF2 Transcription Factor by Increasing the Levels of Phosphorylated p38 and c-Jun N-Terminal Kinases
... or c-Jun–N-terminal kinase (JNK) (26, 58, ...of c-Jun that is known to be phosphor- ylated by JNK), as described in Materials and Methods ...
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Differential roles of p38 MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart
... and c-Jun N-terminal kinases (JNKs) by hyperthermia was investigated in the isolated perfused Rana ridibunda ...° C) was found to profoundly stimulate p38-MAPK phosphorylation ...
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Glossogyne tenuifolia (Hsiang-ju) extract suppresses T cell activation by inhibiting activation of c-Jun N-terminal kinase
... JNK: c‑Jun N‑terminal kinases; LPS: lipopolysac‑ charide; MAPKs: mitogen‑activated protein kinases; MFI: mean fluorescence ...
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Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases.
... signal-regulated kinases (ERKs) and the c-Jun N-terminal kinases ...of c-Fos protein and prolonged synthesis of c-Jun, mediated by N- terminal ...
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Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain
... protein kinases (MAPKs), activated in spinal glia, play an important role in signaling cascades of inflammatory mediators during nerve injury-induced neuropathic pain ...and c-Jun ...
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Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis like systemic inflammatory response in mice
... protein kinases (MAPKs) [extracellular related kinase (ERK) and c-jun-NH2 terminal kinase (JNK)], the production of cytokines [tumor necrosis alpha (TNFa), interleukin-1b (IL-1b), ...
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Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
... signaling kinases may form integral components of transcription complexes, thus in- fluencing gene expression ...JNK, c-Jun migrated to the nuclei of infected ...and c-Jun were at basal ...
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C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
... the C-terminal region of both proteins. The C-terminal domain of TDP-43 is where the major- ity of known ALS/FTD disease mutations have been identified ...the C-term- inal region of ...
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Human Endotoxemia Activates p38 MAP Kinase and p42/44 MAP Kinase, But Not c-Jun N-terminal Kinase
... these kinases as relevant targets for LPS in vivo and suggest that both p38 MAPK and p42/p44 MAPK are of interest with regard to thera- peutical relevance in systemic ...
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DISCOVERY OF NOVEL AND SELECTIVE C JUN NH2 TERMINAL KINASES 2 INHIBITORS BY TWO DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP MODEL DEVELOPMENT, MOLECULAR DOCKING AND ABSORPTION, DISTRIBUTION, METABOLISM, ELIMINATION PREDICTION STUDIES: AN IN SILICO APPROACH
... The QSAR model, developed through the application of MLR and PLS methods, exhibited excellent values for standard statistical parameters and, thereby, proved to be highly reliable and predictable. The descriptors that ...
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ABL N induced apoptosis in human breast cancer cells is partially mediated by c Jun NH2 terminal kinase activation
... ABL- N treatment and produced a sustained elevation for at least 24 hours in MDA-MB-231 cells, which is much ear- lier than the activation of caspase and the ...phosphorylated c-Jun, which appeared ...
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The Jun N-terminal kinases signaling pathway plays a “seesaw” role in ovarian carcinoma: a molecular aspect
... of c-jun in ovarian cancer tissues is high and is correlated with malignancy ...JNK1/ c-jun should result in the ability of cellular proliferation and invasion to be significantly decreased ...
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Regulation of cardiac hypertrophy in vivo by the stress activated protein kinases/c Jun NH2 terminal kinases
... Inhibition of pressure overload–induced cardiac hypertrophy by gene transfer of SEK-1(KR): postmortem measurements. (a and b) Ratio of LV weight to body weight and quantitation of wall thickness. Animals (n = 7 in ...
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Inhibition of c-Jun N-Terminal Kinase Attenuates Low Shear Stress-Induced Atherogenesis in Apolipoprotein E-Deficient Mice
... fluorescence analyses of VCAM-1 expression within vascular endothelium including primary and secondary antibody controls. Representative images acquired by laser scanning con- focal microscopy (400 × ) showed vWF ...
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c Jun N terminal kinase activity supports multiple phases of 3D mammary epithelial acinus formation
... ABSTRACT Primary murine mammary epithelial cells cultured on a laminin-rich-extracellular ma- trix (ECM) require c-Jun N-terminal kinase (JNK) activity for acinus formation. Inhibition of JNK ...
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Acute hypertension activates mitogen activated protein kinases in arterial wall
... MAP kinases has come from studies on cultured ...MAP kinases in rat ...of c- fos , c- jun , and junD gene expres- sion and enhanced DNA-binding activity of AP-1 transcrip- tion factor ...
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Crucial Role of miR-433 in Regulating Cardiac Fibrosis
... fibroblasts. Jun NH2-terminal kinases, including three isoforms (JNK1, JNK2, and JNK3), belong to the MAPK family and play major roles in development, cell proliferation, differentiation, and ...
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c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer
... Previously, Shibata et al. [20] reported that JNK activa- tion was found in 40 % of gastric cancer cases and that there was no association between JNK activation and Lauren’s classification. However, our results showed ...
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