c-jun-NH2-kinase
Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury
... MAP Kinase inhibitors has been proposed as a selec- tive intervention to reduce LPS-induced lung inflamma- tion due to decreases in neutrophil recruitment to the air spaces ...of c-Jun NH 2 -termi- ...
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c Jun NH2 terminal kinase activation is essential for up regulation of LC3 during ceramide induced autophagy in human nasopharyngeal carcinoma cells
... The transcription factor c-Jun, a well characterized JNK substrate, has been shown to play a critical role in apopto- sis [23,24]. The JNK1 signaling pathway has been shown to regulate autophagy in both ...
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Selective activation of the mitogen activated protein kinase subgroups c Jun NH2 terminal kinase and p38 by IL 1 and TNF in human articular chondrocytes
... ERKs are major tyrosine-phosphorylated proteins in IL-1 b stimulated chondrocytes. Previous studies had demonstrated that pharmacologic protein tyrosine kinase inhibitors pre- vented the expression of most IL-1 b ...
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ABL N induced apoptosis in human breast cancer cells is partially mediated by c Jun NH2 terminal kinase activation
... MAP kinase kinase 4 (MKK4) [49], epidermal growth fac- tor receptor (EGFR) [50], insulin growth factor receptor (IGFR) [51] and spleen tyrosine kinase (SYK) [52], have been implicated in the ...
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Ruhe, Jens (2003): Untersuchungen zur pathophysiologischen Funktion der Proteintyrosinphosphatase PTP-LAR in Mammakarzinomzellen. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... inaktiven C/S-Mutante konnte die Bedeutung von SHP-2 für die Aktivierung auch der c-Jun NH2-terminalen Kinase JNK nach Stimulierung des Insulin- sowie des EGF-Rezeptors gezeigt werden, ...
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Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts
... protein C (APC) is a natural anticoagulant that exerts antiinflammatory and cyto-protective effects in various diseases via endothelial protein C re- ceptor (EPCR) and proteinase-activated receptor ...
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Uni-axial stretch induces actin stress fiber reorganization and activates c-Jun NH2 terminal kinase via RhoA and Rho kinase in human bladder smooth muscle cells
... reorganization. ROCK has been reported to participate in the induction of prominent actin stress fiber forma- tion [11]. One of the mechanisms underlying the induc- tion of stress fiber formation by ROCK is the ...
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Regulation of cardiac hypertrophy in vivo by the stress activated protein kinases/c Jun NH2 terminal kinases
... protein kinase Cβ (5), and the serine phosphatase calcineurin and one of its targets, a nuclear factor of acti- vated T cells 3 (NF-AT3) (6) — can induce hypertrophic responses in the hearts of transgenic ...
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Reactive Oxygen Species-Mediated c-Jun NH2-Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction
... FIG 7 Inhibition of ROS-JNK signaling decreases HBV-induced autophagosome formation and its following replication. (A) HepG2 cells were transfected with pHBV1.3, pHBV1.3 with HBx-minus, or the control vector. At 48 h ...
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Checkpoint inhibitors in hematological malignancies
... Janus kinase/ signal transducer and activator of transcription; JNK: c-Jun NH2-terminal kinase; KO: Knock-out; LAG-3: Lymphocyte activation gene 3; LMP1: EBV latent membrane protein 1; ...
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Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH2-Terminal Kinase
... cytochrome c release, and cell death following PV infection depend on JNK ...and c-Jun forms to confirm equal protein ...anti-cytochrome c (Cyt c) ...Cytochrome c release is ...
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Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis like systemic inflammatory response in mice
... related kinase (ERK) and c-jun-NH2 terminal kinase (JNK)], the production of cytokines [tumor necrosis alpha (TNFa), interleukin-1b (IL-1b), interleukin-6 (IL-6), macrophage inhibitory ...
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Modulation of c Jun NH2 Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome
... ABSTRACT Background: We wanted to determine via an immunopharmacological approach whether the c-Jun NH2 terminal kinase JNK cascade is phosphorylated in the submandibular gland by carbac[r] ...
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The activation of c-Jun NH2-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells
... The excessive production of ROS can overcome cells’ defenses against ROS, thus leading to oxidative stress, which is involved in cell injury and apoptosis. Studies showed that DHA led to ROS generation in papilloma ...
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C Jun NH2 Terminal Kinase Contributes to Dexmedetomidine Induced Contraction in Isolated Rat Aortic Smooth Muscle
... lysed in PRO-PREP protein extract solution for total cell lysates, and the lysates were centrifuged at 100,000×g for 20 min at 4°C. Protein concentration was determined using the Bradford method. For preparation ...
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Extracellular signal regulated kinase and c Jun NH2 terminal kinase activation by mechanical stretch is integrin dependent and matrix specific in rat cardiac fibroblasts
... Stretching did not activate p38. This uncoupling of the two stress-activated protein kinases, JNK and p38, is not common. In vitro, most stimuli lead to activation of both pathways (56) while certain stimuli such as ...
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c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... Western blot analysis. Synoviocytes were pretreated with medium or MAPK inhibitors for 30 minutes and fur- ther incubated with IL-1 (2 ng/ml) for 15 minutes. Pro- tein samples (25 µg/lane) from FLS were run on a 10% ...
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Acute hypertension activates mitogen activated protein kinases in arterial wall
... MAP kinase (ERK2/ JNK1) activation in the ...This kinase activation is associ- ated with upregulation of c- fos , c- jun , and junD gene expres- sion and enhanced DNA-binding activity ...
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Tumour necrosis factor activates the mitogen activated protein kinases p38α and ERK in the synovial membrane in vivo
... Immunohistochemistry of phosphorylated MAPKs For immunohistochemical detection of the phosphorylated forms of ERK, p38MAPK α and JNK, ethanol dehydrated tissue sections were treated with 3% hydrogen peroxide in methanol ...
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Vaccinia Virus B1R Kinase Interacts with JIP1 and Modulates c-Jun-Dependent Signaling
... phosphorylate c-Jun in residues different from those targeted by JNK and, interestingly, by its human homologue, VRK1 ...induce c-Jun accumulation (in keeping with the effect of vaccinia ...
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