c-Jun NH2-terminal kinase
Reactive Oxygen Species-Mediated c-Jun NH2-Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction
... ABSTRACT Autophagy is closely associated with the regulation of hepatitis B virus (HBV) replication. HBV X protein (HBx), a multifunctional regulator in HBV-associated biological processes, has been demonstrated to be ...
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Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury
... MAP Kinase inhibitors has been proposed as a selec- tive intervention to reduce LPS-induced lung inflamma- tion due to decreases in neutrophil recruitment to the air spaces ...of c-Jun NH 2 -termi- ...
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Selective activation of the mitogen activated protein kinase subgroups c Jun NH2 terminal kinase and p38 by IL 1 and TNF in human articular chondrocytes
... ERKs are major tyrosine-phosphorylated proteins in IL-1 b stimulated chondrocytes. Previous studies had demonstrated that pharmacologic protein tyrosine kinase inhibitors pre- vented the expression of most IL-1 b ...
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ABL N induced apoptosis in human breast cancer cells is partially mediated by c Jun NH2 terminal kinase activation
... Induction of apoptosis in malignant cells is a critical property of chemopreventive agents. ABL, which has been shown to be potently anti-tumorigenic, has pro- apoptotic features in many carcinoma cell types [17-19]. We ...
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Extracellular signal regulated kinase and c Jun NH2 terminal kinase activation by mechanical stretch is integrin dependent and matrix specific in rat cardiac fibroblasts
... Stretching did not activate p38. This uncoupling of the two stress-activated protein kinases, JNK and p38, is not common. In vitro, most stimuli lead to activation of both pathways (56) while certain stimuli such as ...
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c Jun NH2 terminal kinase activation is essential for up regulation of LC3 during ceramide induced autophagy in human nasopharyngeal carcinoma cells
... substrate c-Jun (Figure 2A). These results indicated that JNK/c-Jun path- way was activated after ceramide treatment in nasophar- yngeal carcinoma ...
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Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts
... protein C (APC) is a natural anticoagulant that exerts antiinflammatory and cyto-protective effects in various diseases via endothelial protein C re- ceptor (EPCR) and proteinase-activated receptor ...
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Uni-axial stretch induces actin stress fiber reorganization and activates c-Jun NH2 terminal kinase via RhoA and Rho kinase in human bladder smooth muscle cells
... reorganization. ROCK has been reported to participate in the induction of prominent actin stress fiber forma- tion [11]. One of the mechanisms underlying the induc- tion of stress fiber formation by ROCK is the ...
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The activation of c-Jun NH2-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells
... Figure 5 Inhibition of JNK expression downregulates Beclin 1 and represses autophagy. (A) BxPC-3 and PANC-1 cells were treated with different concentration of DHA for 24 h in the presence or absence of 10 μ mol/L ...
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Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH2-Terminal Kinase
... cytochrome c release, and cell death following PV infection depend on JNK ...and c-Jun forms to confirm equal protein ...anti-cytochrome c (Cyt c) ...Cytochrome c release is ...
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C Jun NH2 Terminal Kinase Contributes to Dexmedetomidine Induced Contraction in Isolated Rat Aortic Smooth Muscle
... dexmedetomidine-induced maximal contractions in a con- centration-dependent manner, these results suggest that dex- medetomidine-induced contraction is primarily mediated by activation of a JNK-mediated pathway and, in ...
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Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis like systemic inflammatory response in mice
... related kinase; I B a : inhibitor of kappaB alpha; IL: interleukin; JNK: c-jun-NH2 terminal kinase; LPS: lipopolysaccharide; MAPK: mitogen-activated protein kinase; MIP: ...
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Checkpoint inhibitors in hematological malignancies
... Janus kinase/ signal transducer and activator of transcription; JNK: c-Jun NH2-terminal kinase; KO: Knock-out; LAG-3: Lymphocyte activation gene 3; LMP1: EBV latent membrane ...
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Modulation of c Jun NH2 Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome
... ABSTRACT Background: We wanted to determine via an immunopharmacological approach whether the c-Jun NH2 terminal kinase JNK cascade is phosphorylated in the submandibular gland by carbac[r] ...
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Regulation of cardiac hypertrophy in vivo by the stress activated protein kinases/c Jun NH2 terminal kinases
... protein kinase Cβ (5), and the serine phosphatase calcineurin and one of its targets, a nuclear factor of acti- vated T cells 3 (NF-AT3) (6) — can induce hypertrophic responses in the hearts of transgenic ...
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DISCOVERY OF NOVEL AND SELECTIVE C JUN NH2 TERMINAL KINASES 2 INHIBITORS BY TWO DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP MODEL DEVELOPMENT, MOLECULAR DOCKING AND ABSORPTION, DISTRIBUTION, METABOLISM, ELIMINATION PREDICTION STUDIES: AN IN SILICO APPROACH
... c-Jun NH2-terminal kinases (JNKs), one of the stress-activated kinases, are the member of mitogen-activated protein kinase ...utilize c-Jun as a substrate to evaluate the ...
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Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer’s disease
... In vitro and in vivo, microglia pro-inflammatory activ- ity is associated with an ameboid-like phenotype and the expression of pro-inflammatory cytokines and chemo- kines related to the M1 macrophage phenotype. DHA ...
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Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I
... protein kinase; miRNAs, MicoRNAs; MMP9, Matrix metalloproteinase 9; MTT, 3-(4, 5)-dimethylthiahiazo (-z-y1)-3, 5-di-phenytetrazoliumromide; NF-kB, Nuclear factor-kB; NSCLC, Non-small cell lung cancer; PBS, ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... Expression of catalytically inactive USP14 in the nervous systems of TgUsp14CA mice led to enhanced K63-linked ubiquitination of MLK3 (Figure 6A and B), which has previously been demonstrated to induce its dimerization, ...
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Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
... Tracking the induction of JNK by confocal microscopy pro- vided an approach to studying the kinetics of JNK activation that did not depend on a high MOI. Analysis of phospho-JNK at the edges of plaques, where infection ...
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