C-promoter binding factor 1
Direct, Interferon-Independent Activation of the CXCL10 Promoter by NF-κB and Interferon Regulatory Factor 3 during Hepatitis C Virus Infection
... Hepatitis C virus (HCV) infection of hepatocytes leads to transcriptional induction of the chemokine CXCL10, which is consid- ered an interferon (IFN)-stimulated ...CXCL10 promoter contains binding ...
9
Transcriptional Regulation of BK Virus by Nuclear Factor of Activated T Cells
... viral promoter. To elucidate the mechanisms of increased promoter activity due to NFAT binding site mutations on the viral promoter, we investigated the binding of AP-1 and ...
9
HIV 1 clade promoters strongly influence spatial and temporal dynamics of viral replication in vivo
... AP-1 binding is increased in T lymphocytes stimulated with IL-7 ...nuclear factor of activated T cells (NFAT), which binds to NF-κB binding sites, acts synergistically with AP-1 if ...
12
Identification and expression profiling of Pht1 phosphate transporters in wheat in controlled environments and in the field
... transcription factor PHR1 activates several Pi starvation-induced genes by binding to the P1BS promoter element (Rubio et ...transcription factor have been reported to be involved in the ...
16
The Elk-1 and Serum Response Factor Binding Sites in the Major Immediate-Early Promoter of Human Cytomegalovirus Are Required for Efficient Viral Replication in Quiescent Cells and Compensate for Inactivation of the NF-κB Sites in Proliferating Cells
... kinase C (PKC), mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK), and the p38/MAPK pathways (14, 26, 31, 35, ...tained binding of a protein complex to the SEE ...SRF ...
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The Host Factor Polyhedrin Promoter Binding Protein (PPBP) Is Involved in Transcription from the Baculovirus Polyhedrin Gene Promoter
... polh promoter also directly involves the ubiqui- tous TBP required for eukaryotic transcription initiation (41, ...the promoter-binding activity of TBP, the crucial step in the nucleation event, has ...
10
Molecular cloning of metal-responsive transcription factor-1 (MTF-1) and transcriptional responses to metal and heat stresses in Pacific abalone, Haliotis discus hannai
... transcription factor binding sites such as heat shock element (HSE; GAANRTTC; −1003 and −32 bp; targeted by heat shock factor (HSF)), hypoxia response element (HRE; RCGTG; −895 and −285 bp; by ...
13
Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells
... MGMT promoter to inhibit its expression(Natsume et ...increasing binding of protein p53 to the MGMT promoter as evidenced by ChIP and confirmed by down-regulating p53 expression with shRNA p53 ...
19
Interactions between c-Jun, Nuclear Factor 1, and JC Virus Promoter Sequences: Implications for Viral Tropism
... specific binding by NF-1 class members (NF-1 ...outcompeted binding to the radiolabeled probe (lane 4), while unlabeled mutant oligonucleotide (mutant competitor) did not (lane ...nonspecific ...
8
Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes
... The promoter polymorphism -20 C/A (rs5050) is a functional SNP; it affects binding of upstream stimu- lating factor 2 (USF2) leading to the higher transcription of minor C allele ...
7
Proto-oncogenic miR-744 is upregulated by transcription factor c-Jun via a promoter activation mechanism
... progression. C-Jun can not only form the AP-1 early response transcription factor in combination with c-Fos, but also act as an independent transcription factor ...transcription ...
10
Molecular regulation of the expression of leptin by hypoxia in human coronary artery smooth muscle cells
... against c-Jun N-terminal kinase (JNK) and mono- clonal antibodies (mAbs) against phospho-JNK were obtained from Cell Signaling (Beverly, MA, ...type 1 receptor blockers), HCASMCs were treated with 100 nM ...
14
Characterization of an acquired inhibitor to coagulation factor V Antibody binding to the second C type domain of factor V inhibits the binding of factor V to phosphatidylserine and neutralizes procoagulant activity
... Hematol. 4:193-206). This inhibitor was shown to be an IgG antibody that bound to the light chain of Factor V. Using a series of light chain deletion mutants, we have found that this antibody binds to the second ...
9
Regulation of the Aspergillus nidulans cytochrome C gene : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Genetics at Massey University, Palmerston North, New Zealand
... nidulans cytochrome c gene was obtained, and putative regulatory signals including the HAP 1 binding site were found, and compared with published promoter sequences which regulate the ex[r] ...
14
Regulation of the Aspergillus nidulans cytochrome C gene : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Genetics at Massey University, Palmerston North, New Zealand
... nidulans cytochrome c gene was obtained, and putative regulatory signals including the HAP 1 binding site were found, and compared with published promoter sequences which regulate the ex[r] ...
139
DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases
... MAPK are switched off by both generic phosphatases and dual-specificity phosphatases (DUSPs) and are fur- ther regulated by scaffold proteins, which are usually specific for each of the three major mammalian MAPK ...
13
A transferable heterogeneous two-hybrid system in Escherichia coli based on polyhydroxyalkanoates synthesis regulatory protein PhaR
... Results presented here have proven the feasibility of this bacterial two-hybrid system. However, further research should be carried out to obtain an optimal DBD without any PHB binding ability, which will con- ...
8
Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter.
... type 1 (HTLV-1) is associated with two disparate clinical syndromes: adult T-cell leukemia (41) and tropical spastic paraparesis (also known as HTLV-1- associated myelopathy) ...
10
NKX2-1-mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NF-κB activation
... IKKβ expression modulated by the NKX2-1/p53 axis at transcription level is responsible tumour progression in lung adenocarcinoma. The IKKβ-mediated p65 nuclear localization is essential for promoting inflammatory- ...
16
The Autoregulatory and Transactivating Functions of the Human Cytomegalovirus IE86 Protein Use Independent Mechanisms for Promoter Binding
... and is not recruited to early viral promoters in 293 and HFF cells. (A) 293 cells were transfected, in duplicate, with a reporter construct consisting of the CAT gene under the control of the early UL4 or UL112 promoters ...
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