c-src-tyrosine kinase
Use of QSAR Global Models and Molecular Docking for Developing New Inhibitors of c-Src Tyrosine Kinase
... members, c-src tyrosine kinase is a therapeutically interesting target, because its inhibition might be of interest not only in a number of malignancies, but also in a diverse array of ...
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Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury
... of c-Src and increase the deg- radation of occludin, and the c-Src inhibitor PP2 could re- verse these ...that c-Src inhibitor could ameliorate pulmonary edema and alleviate ...
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Elevated c Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis
... Thus, Src activity is elevated in premalignant UC epithelia, which is at greatest risk for developing ...the src proto- oncogene is an early event in the genesis of UC colon ...
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Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor and c Src interactions in breast cancer
... nonreceptor tyrosine kinase that is localized to intracellular membranes of the cell, has also been found to be overexpressed or highly activated in a number of human neoplasms, including carcinomas of the ...
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Epithelial Cell Adhesion to Extracellular Matrix Proteins Induces Tyrosine Phosphorylation of the Epstein-Barr Virus Latent Membrane Protein 2: a Role for C-Terminal Src Kinase
... of tyrosine phosphorylation in ...at tyrosine 101, YSPR, predicted to represent a dock- ing site for the SH2 domain of Csk, and the YEEA motif surrounding tyrosine 112, an interaction site for the ...
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IN SILICO INHIBITION OF PROTO ONCOGENE TYROSINE PROTEIN KINASE SRC (C SRC) BY ARISTOLACTAM A II, 4 ALLYL RESORCINOL AND STIGMAST 4 EN 3, 6 DIONE FOR ANTICANCER ACTIVITY OF PIPER BETLE LINN (PIPERACEAE): TRADITIONAL CLAIM REVALIDATED
... proto-oncogene tyrosine protein kinase Src (c-Src) and Cyclin dependent kinase 2 (CDK2) was selected based on their report of anticancer activity and listing in target prediction ...
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Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein
... that tyrosine phosphorylation of Mint1 regulates the destination of ...on tyrosine by C-Src and recruits the active kinase for sequential phosphorylation of further tyrosines (Y191 and ...
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SRC 1, a non receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C elegans
... tyrosine kinase(s) in the UNC-6/netrin signaling pathway (Killeen et ...vertebrate Src family kinase is required for the phosphorylation of the netrin receptor and its subsequent cell ...
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Ghrelin induced cSrc activation through constitutive nitric oxide synthase dependent S nitrosylation in modulation of salivary gland acinar cell inflammatory responses to Porphyromonas gingivalis
... cellular Src (cSrc), a member of the non-receptor protein tyrosine kinase Src family ...the Src family kinases share similar structural organiza- tion, consisting of N-terminal ...
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Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice
... and Src kinase ...wild-type Src-pep sequences and the BSRmut molecule, which contains two tyrosine-to-phenylalanine substitutions at the putative phosphorylation ...in Src-dependent ...
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Role of phosphatidylinositol 3-kinase as an effector of Ras
... involving tyrosine phosphoprotein binding to ...serine/threonine kinase, or an amino-termin- ally truncated, activated version o f c-R af (A R af), which act immediately downstream o f Ras to ...
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Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells
... of Src in ILTV infection in chicken embryos treated with serially increasing dosages of ...and C) Virus production in allantoic fluid (B) and the chorioallantoic membrane (C) was detected by ...
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1,25 dihydroxyvitamin D3 stimulates phospholipase C gamma in rat colonocytes: role of c Src in PLC gamma activation
... cells, Src was required for nerve growth factor-induced differ- entiation with neurite outgrowth ...(42). Src has also previously been implicated in endothelial cell migration ...in c-Src ...
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Regulation of the Src Family Kinases by Csk
... 2) tyrosine phosphatases dephosphorylate the exposed pTyr-527 to stabilize the active conformation; and 3) the activated SFKs un- dergo intermolecular auto-phosphorylation on Tyr-416 to lock the catalytic pocket ...
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Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors
... family tyrosine kinases (SFKs) are the subject of major interest due to their critical roles in signal transduction pathways and cellular functions such as invasion, division, differentiation, survival, adhesion ...
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Acid sensing in renal epithelial cells
... proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid ...
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Herbimycin A, a pp60c src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo
... the c-src gene product in mice indicates that the pp60c-src tyrosine kinase is required and essential for osteoclastic bone resorption, we tested the effects of the antibiotic ...
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An ITAM in a Non-enveloped Virus (Reovirus) Regulates Activation of NF-kB, Induction of Interferon-ß, and Viral Spread.
... 21 kinase is highly expressed in hematopoietic cells and has also been shown to be expressed in nonhematopoietic cells including fibroblast, epithelial cells, hepatocytes, neuronal cells, and vascular endothelial ...
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Cytoskeletal signaling proteins : complex regulatory mechanisms and roles in innate immunity
... dependent upon ERK activation, there is no evidence that this site is directly phosphorylated by ERK. Further, the sequence flanking serine 126 does not conform to a consensus ERK phosphorylation site. Note however, that ...
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Series Introduction: Invasive growth: from development to metastasis
... However, quantitative, threshold effects — producing qualitatively different biological responses from a sin- gle, generic signal — may not fully account for the asso- ciation between Met and invasive growth. Evidence ...
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