C1 esterase inhibitor
Genetically determined heterogeneity of the C1 esterase inhibitor in patients with hereditary angioneurotic edema
... normal C1 esterase inhibitor by Ouchterlony analysis, but they were different from normal and from each other with respect to their electrophoretic mobility, their capacity to bind C1 ...
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The effect of C1 esterase inhibitor on systemic inflammation in trauma patients with a femur fracture The CAESAR study: study protocol for a randomized controlled trial
... of C1-esterase inhibitor (C1-INH) [21]. C1- INH is an acute phase protein, produced by the liver in response to inflammatory ...conditions. C1-INH is a major inhibitor for ...
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Self-administered C1 esterase inhibitor concentrates for the management of hereditary angioedema: usability and patient acceptance
... functional C1 esterase inhibitor ...with C1-INH concentrates is employed for on-demand treatment of acute attacks and long-term ...plasma-derived C1-INH preparations are approved for ...
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Endotoxin induced pulmonary dysfunction is prevented by C1 esterase inhibitor
... the C1-esterase inhibitor (C1-INH), a main inhibitor of the blood coagulation contact system, on the cardiovascular and respiratory dysfunction associated with endotoxic ...a ...
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Successful use of daily intravenous infusion of C1 esterase inhibitor concentrate in the treatment of a hereditary angioedema patient with ascites, hypovolemic shock, sepsis, renal and respiratory failure
... in C1 esterase inhibitor ...plasma-derived C1-INH (pdC1-INH) concentrate is indicated for the treatment of both acute HAE attacks and pre-procedure prevention of HAE episodes in patients ...
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Human Complement Regulators C4b Binding Protein and C1 Esterase Inhibitor Interact with a Novel Outer Surface Protein of Borrelia recurrentis
... The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B. recurrentis ...
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Bench to bedside review: The role of C1 esterase inhibitor in sepsis and other critical illnesses
... with C1 INH was associated with reduced clinical severity, a less pronounced infl ammatory infi l- trate around the meninges, and lower brain levels of pro- infl ammatory cytokines and ...chemokines. C1 INH ...
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Isolated angioedema of the bowel due to C1 esterase inhibitor deficiency: a case report and review of literature
... The diagnosis of angioedema is made in the context of the appropriate constellation of medical history and clinical findings along with supportive laboratory data. HAE should be suspected when there is a history of ...
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Recent developments in the treatment of acute abdominal and facial attacks of hereditary angioedema: focus on human C1 esterase inhibitor
... purified C1-INH produced by Immuno Pharmaceuticals, Viena, in 1980 (brand name C1 Inactivator) were infected with hepatitis C virus (HCV), even though no patient was reported to be infected by human ...
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Abstracts from the 10th C1-inhibitor deficiency workshop
... Background: From the1960 s, biochemical studies indicated that the deficiency of C1 esterase inhibitor (C1-INH) isthe disorder of hereditary angioedema (HAE) [1, 2].Only since the 1980s, have ...
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Hereditary angioedema: New therapeutic options for a potentially deadly disorder
... In 1888, Sir William Osler provided a medical description of angioedema (AE) that distinguished an inherited form of the disease[1]. His description was the first to provide full clinical details. Seventy-five years ...
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Angioedema in the emergency department: a practical guide to differential diagnosis and management
... Review: The most common pathophysiology underlying angioedema is mediated by histamine; however, ED staff must be alert for the less common bradykinin-mediated forms of angioedema. Crucially, bradykinin-mediated ...
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Abstracts of 11th C1-inhibitor Deficiency & Angioedema Workshop
... Between October 2017 and February 2019 patients attending HAE clin- ics were approached to complete the questionnaire and 24 agreed. All HAE patients in our clinics have access to a range of therapies. Some pre- fer to ...
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Emerging concepts in the diagnosis and treatment of patients with undifferentiated angioedema
... missing C1-INH in patients with ...of C1-INH that was approved by the US Food and Drug Adminis- tration (FDA) in 2009 for the treatment of acute abdom- inal, facial, and, more recently, laryngeal attacks of ...
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Diagnosis and treatment of hereditary angioedema with normal C1 inhibitor
... of C1 esterase inhibitor (C1-INH) caused by mutations of the C1-INH ...normal C1-INH concentration and activity with respect to C1 esterase inhibition, ruling out ...
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Pediatric hereditary angioedema due to C1-inhibitor deficiency
... the C1-INH gene can be detected in 8 to 10 per cent of cases ...the C1-INH gene itself may not be a valid indication for terminating pregnancy because it may cause a non-fatal, manageable disease in the ...
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Nine year follow-up of a rare case of angioedema due to acquired C1-inhibitor deficiency with late onset and good response to attenuated androgen
... to C1-INH deficiency ...of C1-INH (C1-INH-AAE) is a rare disease that may have some clinical and laboratory similarities with hereditary angioedema, but without family history and with onset after ...
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Acquired angioedema
... deficiency of C1-INH due to mutations in one of the two alleles coding for this protein [5]. This could be anticipated based on the fact that in both forms angio- edema is mediated by bradykinin episodically ...
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Platelet C1 inhibitor A secreted alpha granule protein
... contain C1- inhibitor. By means of monospecific antibody to C1- inhibitor, a competitive enzyme-linked immunosorbent assay (CELISA) was developed to measure directly platelet C1- ...of ...
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Abdominal attacks and treatment in hereditary angioedema with C1-inhibitor deficiency
... nanofiltered, C1-INH (Human) replacement product also approved for prophylaxis ...nanofiltered C1-INH (Human) replacement product [32]; FIRAZYR® (icatibant, Shire, Lexington, MA), a bradykinin B2 receptor ...
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