C2H2 zinc finger
KNUCKLES (KNU) encodes a C2H2 zinc finger protein that regulates development of basal pattern elements of the Arabidopsis gynoecium
... We isolated a recessive, conditionally male-sterile Arabidopsis mutant, knuckles (knu). A fraction of knu flowers produce ectopic stamens and carpels in a reiterating pattern from placental tissue near the base of a ...
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BmBlimp-1 gene encoding a C2H2 zinc finger protein is required for wing development in the silkworm Bombyx mori
... a C2H2 zinc finger protein gene BGIBMGA000319 that is highly expressed during the silkworm pupal ...the zinc finger motif of the Blimp-1 gene is highly conserved among multiple insect ...
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Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins
... proteins. C2H2 zinc finger proteins (ZFPs) constitute the largest family of human ...All C2H2 ZFPs contain a highly conserved linker sequence joining their multi-zinc finger ...
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A Developmental Genetic Analysis of the C2H2 Zinc Finger Encoding Gene, Disconnected, in Drosophila Melanogaster and Tribolium Castaneum
... expressed zinc finger transcription factors, and they are required in parallel with the Hom-C proteins for proper segment ...another C2H2 zinc finger protein, ...other zinc ...
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Disconnected, a C2H2 Zinc Finger Protein, has a role in Appendage Formation and Gene Regulation in Drosophila.
... The Homeotic/Hox proteins are evolutionarily conserved proteins that specify segment identity by regulating segment-specific batteries of target genes. One the biggest questions in developmental biology is how the Hox ...
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Comparative analysis of the genetic variability within the Q-type C2H2 zinc-finger transcription factors in the economically important cabbage, canola and Chinese cabbage genomes
... Q-type C2H2 zinc-finger protein (ZFP) transcription factors contain zinc finger motifs with a conserved QALGGH as part of the motif and they may play a critical role in the plants ...
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Non base contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding
... metazoan C2H2-ZFs evolu- tionary time and has shaped both the diversity of binding motifs and the frequency landscape of base-contacting residue combinations among modern ...of C2H2-ZFs, we introduce the ...
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Multifunctional Involvement of a C2H2 Zinc Finger Protein (PbZfp) in Malaria Transmission, Histone Modification, and Susceptibility to DNA Damage Response
... gers (ZnF). Reverse genetic approaches were used to create Plasmodium berghei par- asites either lacking expression of full-length Plasmodium berghei zinc finger protein (PbZfp) (knockout [KO]) or expressing PbZfp ...
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Identification of conserved C2H2 zinc finger gene families in the Bilateria
... The limitations of BLAST and molecular phylogenetics lead us to seek alternative criteria for defining orthology of C2H2 ZNF genes. We used percentage amino-acid sequence iden- tity over the ZNF region, as ...
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Zinc finger proteins in cancer progression
... conserved zinc finger motifs, is found acetylated at the lysine residues adjacent to the C terminal zinc finger by acetyltransferase CBP and ...its zinc finger motif mediated by ...
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The Zinc Finger Antiviral Protein Directly Binds to Specific Viral mRNAs through the CCCH Zinc Finger Motifs
... The zinc finger antiviral protein (ZAP) was originally recov- ered from a screen for genes conferring resistance to the in- fection of cells by Moloney murine leukemia virus (MLV) ...
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Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf)
... proteins act as E3 ubiquitin ligases and are associated with the ubiquitin proteasome pathway [45]. In human genome, more than 600 RING finger proteins were annotated as E3s [46]. Whether Znf179 functions as an E3 ...
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Mutagenesis analysis of the zinc finger antiviral protein
... Results: A series of ZAP mutants was generated, in which three consecutive amino acids were replaced with three alanines. The mutants were analyzed for their antiviral activities against pseudotyped MLV vector. Out of ...
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The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain
... The MDM2 protein was initially tested to deter- mine if it was capable of binding to RNA because of the presence of the central zinc finger and C-terminal RING finger domains in the prot[r] ...
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Zinc finger proteins in early Xenopus development
... Int J De\' BioI 40 291 295 (1996) 291 Zinc finger proteins in early Xenopus development THOMAS HOLLEMANN, ERIC BELLEFROID, REIMER STICK and TOMAS PIELER* Georg August Universitat Gdttingen, Institut f[.] ...
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Plasmodium falciparum Hep1 is required to prevent the self aggregation of PfHsp70-3
... essential zinc-finger protein, Hsp70-escort protein 1 (Hep1), to maintain its structure and ...PfHsp70-3. Zinc ions were indeed essential for maintaining the function of PfHep1, as EDTA chelation ...
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Contribution of the Zinc Finger to Zinc and DNA Binding by a Suppressor of Posttranscriptional Gene Silencing
... In summary, we have found that a correlation exists between the biochemical properties of the C2 protein encoded by the monopartite begomovirus TYLCV-C and its biological func- tions in pathogenesis and PTGS suppression. ...
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Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins
... adjacent zinc finger, 1A; BAZ1B: Bromodomain adjacent zinc finger, 1B; BCPs: Bromodomain- containing proteins; Brd1: The first bromodomain protein gene; Brd2: The second Brd protein gene; BRM: ...
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Evaluation and application of modularly assembled zinc finger nucleases in zebrafish
... the Zinc Finger Consortium-based CoDA ZFPs this has been directly demonstrated on a large scale, in which ~50% of ZFNs were active in vivo (Sander et ...
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Zinc Finger Domain of Murine Leukemia Virus Nucleocapsid Protein Enhances the Rate of Viral DNA Synthesis in Vivo
... of direct-repeat deletion and GFP reconstitution for the wild- type NC was 10.8% (Table 1). Each NC mutant was analyzed in two independent experiments so that the statistical signifi- cance of the results could be ...
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