Ca 2+ , ROS and cell death
Mitochondrial calcium uptake underlies ROS generation during aminoglycoside induced hair cell death
... chondrial ROS production may be of therapeutic value to patients taking large and/or prolonged courses of aminoglycoside antibiot- ...hair cell protection is incomplete in our zebrafish model, even when ...
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Original Article Hesperidin-triggered necrosis-like cell death in skin cancer cell line A431 might be prompted by ROS mediated alterations in mitochondrial membrane potential
... carcinoma cell line A431 and to investigate the underlying ...determine ROS, Ca 2+ , mitochondrial membrane potential (ΔΨ m ...A431 cell line. Moreover, hesperidin reduced the ...
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Aloe-emodin triggers ROS and Ca 2+ production and decreases the levels of mitochondrial membrane potential of human brain capillary endothelial cells
... of cell proliferation in human micro vascular endothelial cells treated with ...induces ROS generation in a dose dependent manner, showing the pro-oxidant properties of AE in endothelial hCMEC/D3 ...
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Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca 2+ release
... 15d-PGJ2-induced vacuoles formation was mediated by both the MEK-1 and -2 cascades [41]. We showed here that Gyp-L treatment triggered the generation of ROS and UPR response. This process has also been ...
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Vascular patterning regulates interdigital cell death by a ROS mediated mechanism
... Interestingly, prior to the onset of PCD, the autopod vasculature undergoes extensive patterning that results in high interdigital vascularity. Here, we show that in mice, the limb vasculature positively regulates ...
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Cell Death by Polyvinylpyrrolidine-Coated Silver Nanoparticles is Mediated by ROS-Dependent Signaling
... on cell death induction in the murine dendritic cell line ...in cell viability and an induction of lactate dehydrogenase (LDH) leakage in a time- and dose-dependent ...AgNP-induced ROS ...
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6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
... Cell culture Embryonic day 14 (E14) CF1 murine midbrains (Charles River Laboratories, Wilmington, MA, USA) were pre- pared as described [6]. To assess survival of neurons after 6-OHDA treatment, mice heterozygous ...
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Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production
... DISCUSSION In this study, we discovered that NA triggers necroptosis by promoting autocrine secretion of TNFα through the regulation of the RIPK/NF-κB signaling pathway and RIPK3-dependent ROS production. NA ...
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Chelerythrine induced cell death through ROS-dependent ER stress in human prostate cancer cells
... increased rOs accumulation in Pc-3 cells A previous study has shown the induction of ROS-stimulated distinctive autophagy by CHE in non-small cell lung cancer ...on ROS production in PC-3 ...
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CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer
... induced cell death in many types of tumor, including acute myeloid leukemia (AML), breast cancer, colorectal cancer, neuroblastoma, and inhibited tumor growth in primary AML cells xenografts as well as ...
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Carnosol induces apoptotic cell death through ROS-dependent inactivation of STAT3 in human melanoma G361 cells
... producing ROS as a by-product of the oxidative phos- phorylation ...of ROS level [47]. In our study, carnosol treatment generated ROS from the lowest dose, 20 μM, and this increase in cellular ...
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<p>Chitosan gold nanoparticles induce different ROS-dependent cell death modalities in leukemic cells</p>
... the cell death mechanism ...leukemic cell lines: CEM, from T-ALL, and K562, from ...MCF-7 cell lines, as the CC 50 in leukemic cell lines is 25 µM, while in HeLa and MCF-7 cells it was ...
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UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells
... 2.6. Immunoblot analysis To analyze GAPDH distribution nuclear and cytoplasmic protein extracts were obtained with Nuclear Extract Kit (Active Motif), electrophoresed through a 12% SDS-polyacrylamide gel, and electro- ...
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Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death
... of ROS-induced TRPM2 channel activation in SH-SY5Y cells is critical for the question of whether or not this human cell model can be used to gain insights into the molecular and signaling mechanisms for ...
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Coenzyme Q10 Protects Astrocytes from ROS-Induced Damage through Inhibition of Mitochondria-Mediated Cell Death Pathway
... 20,000 cell per well were seeded in 96 well ...Whole cell staining with Janus Green was also done to remove variation due to cell loss during the ...
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Cell Injury. Cell Death
... Radiation, ROS release, toxins, chemotherapeutic agents, among others (Mitochondrial Pathway) In receptor-mediated apoptosis, the process is initiated by the binding of the ligand to its receptor in the ...
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<p>Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway</p>
... from the Western blot analysis demonstrated that cleaved caspase-3, cleaved caspase-9 and cleaved paep1 were increased in this context. In addition to apoptosis, autophagy, which is also called type II programmed ...
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YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway
... Discussion Chemotherapy is widely accepted as one of the most common clinical treatments for advanced cancers. However, patients exposed to long-term chemotherapy are inclined to be unresponsive to chemo-drugs. MDR ...
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Tetrahydroxystilbene Glucoside Exerts Cytoprotective Effect against Hydrogen Peroxide-induced Cell Death Involving ROS Production and Antioxidant Enzyme Activation
... decreased cell viability, whereas pre-incubating cells with 10 μΜ tetrahydroxystilbene glucoside for 24 h protected the cells against hydrogen peroxide cell damage, and more significantly in gastric ...
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PI3Kγ Mediates Microglial Proliferation and Cell Viability via ROS
... abolic and repair responses during immune tolerance before cell death. Following this basic principle, we suggest that the decreased viability of microglia at high doses of LPS and ATP is embedded in the ...
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