CA1 area
A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
... The mice were perfused with 4% paraformaldehyde in phosphate-buffered saline, and the brain was dissected and placed in sucrose solution. After cryoprotection using a 15 and 30% sucrose gradient, coronal hippocampal ...
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Acupuncture attenuates cognitive deficits and increases pyramidal neuron number in hippocampal CA1 area of vascular dementia rats
... hippocampal CA1 [6,20], and permanent occlusion of the bilateral common carotid arteries in animals induces significant pyramidal neuron loss in hippocampal CA1 area ...hippocampal CA1 did not ...
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NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area
... the stratum radiatum of the CA1 area was randomly photographed. Double-labeling postembedding immunocytochemistry. Ultrathin sec- tions picked up on pioloform-coated 400 mesh nickel grids were reacted as ...
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STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity
... in CA1 area of hippocampus in DU mice revealed significant reduction in post- synaptic density (PSD) of mushroom spine synapses at 12 months of age ...in CA1 area (stratum radiatum) of ...
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Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia
... A total of 100 mg of hippocampal tissues were collected from each group, which were then subjected to a paraffin- embedded process, cut into sections, dewaxed and dehy- drated. The sections were then cut into coronal ...
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Association of Cdk5 and Soluble Oligomeric Species of β-amyloid Induced Tau Hyperphosphorylation
... Ammonis area 1 (CA1). Within 7 to 21 days after the operation, the area of Aβ42 decreased ...the CA1 area and subgranular zone (SGZ), correlates with increased phosphorylation of ...
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Original Article MiR-124 effect in neurons apoptosis in newborn rat with thyroid hypofunction
... at CA1 area was obviously larger in thyroid hypofunc- tion group and miR-124 negative control group when compared with control, while apoptotic cell number declined after treated with miR- 124 mimics ...
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Protective Effects of Nucleobinding-2 After Cerebral Ischemia Via Modulating Bcl-2/Bax Ratio and Reducing Glial Fibrillary Acid Protein Expression
... This study, for the first time to date, demonstrated the neuroprotective effects of nesfatin-1 against I/R injury by GFAP immunohistochemical staining. So that the num- ber of active GFAP-positive cells significantly ...
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The Effect of Various Hyperglycemia Rates on CA1 Neuronal Density in Male Rats
... At first forty male rat divided to four groups randomly (control and experimental 1, 2, 3). Hyperglycemia was induced by a single injection (i.p.) of streptozotocyn (45, 50,55mg/kg). Control animals were given an equal ...
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Protection of Hippocampal CA1 Neurons Against Ischemia/Reperfusion Injury by Exercise Preconditioning via Modulation of Bax/ Bcl-2 Ratio and Prevention of Caspase-3 Activation
... the CA1 pyramidal neurons in hippocampus are particularly vulnerable to isch- emic insult; in fact, these neurons die 3-7 days after transient forebrain ischemia (Ouyang, Voloboueva, Xu, & Giffard, ...the ...
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Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus
... The density of Iba1 immunoreactive microglial cells in the hippocampus was investigated because of this brain re- gion’s proven role in both of the behavioral tasks employed herein. Our group has previously demonstrated ...
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A role of p38 mitogen-activated protein kinase in adenosine A1 receptor-mediated synaptic depotentiation in area CA1 of the rat hippocampus
... We and other laboratories have previously shown that an increase of extracellular adenosine acting on adenosine A 1 receptors may be a component of the mechanism that triggers LFS-induced depotentiation in the ...
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A depletable pool of adenosine in area CA1 of the rat hippocampus
... Many studies have found that repeated sublethal episodes (2–3 min) greatly exacerbate the biochemical changes associated with hypoxia/ischemia (Mrsulja et al., 1977), including increased cal- cium accumulation within ...
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Expression of one important chaperone protein, heat shock protein 27, in neurodegenerative diseases
... The degree and distribution of HSP27 immunostaining in both white matter and grey matter were scored semiquan- titatively in temporal cortex and hippocampus, and/or frontal cortex, on a 5-point scale (0 = absent; 1 = ...
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Voltage activated currents in hippocampal CA1 neurones
... It can be seen that many of the cells showed a pyramidal shape and retained some of their proximal dendritic stumps. Many cells however had no dendritic processes and were small and round. It was felt that these cells ...
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Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury
... mean area of the undamaged tis- sue was measured in the four brain sections and multiplied by 1 mm to account for the distance between each tissue section to find tissue ...
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Research Paper: Cross State-dependent Learning Interaction Between Scopolamine and Morphine in Mice: The Role of Dorsal Hippocampus
... Finally, cross state-dependent effect was observed be- tween morphine and SCO on retrieval of passive avoid- ance memories in mice. It seems that the bidirectional modulatory relationship between the cholinergic and ...
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Delay-dependent impairment of spatial working memory with inhibition of NR2B-containing NMDA receptors in hippocampal CA1 region of rats
... of CA1 region NR2B-NMDARs in spatial working memory, we trained rats on a delayed matching-to-place task in water maze (DMP ...the CA1 region 15 min before rats performed the ...
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Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity dependent activation of adenosine A1 receptors
... Electrophysiological recordings. Except for one series of experiments, slices (comprising hippocampus and overlying neocortex) were incu- bated for 3– 8 h in standard aCSF or for 2 h in aCSF supplemented with 1 m M ...
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Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice
... Addiction involves long-lasting maladaptive changes including development of disruptive drug-stimuli associations. Nicotine-induced neuroplasticity underlies the development of tobacco addiction but also, in regions such ...
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