Calcineurin activity
Downregulation of calcineurin activity in cervical carcinoma
... of calcineurin is the NFAT family of transcription factors. Calcineurin dephosphorylates NFAT allowing translocation of this protein into the nucleus ...binding activity of NFAT seem at odds in view ...
8
Aldosterone and dexamethasone stimulate calcineurin activity through a transcription independent mechanism involving steroid receptor associated heat shock proteins
... in calcineurin phos- phatase activity by steroid ...increased calcineurin activity in microdissected rat cortical collecting ducts (CCD) and connecting tubules, but not in proximal tubules, ...
8
Pharmacodynamic monitoring of calcineurin inhibition therapy : investigation of the calcineurin activity marker
... CN activity measurement outcome. When applying CN activity monitoring in clinical practice CN activity could therefore be biased by sample ...CN activity assay protocol, adequate analytical ...
137
Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible
... micrograms/l, washed, and resuspended in CsA-free medium showed little recovery (0- 20%) after 24 h. Erythrocytes or anti-CsA Ab added to the recovery medium increased recovery to 50% within 4 h. Similar recovery was ...
8
Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae
... mammals, calcineurin activation of transcription factor EB (TFEB) in response to lysosomal Ca 21 signals regulates autophagy initiated by oxidative stress or nutrient depriva- tion (Medina et ...2017). ...
13
Individualized dosing of calcineurin inhibitors in renal transplantation
... of calcineurin activity measurements in ...quantify calcineurin activity in vitro, concessions are being ...to calcineurin activity in ...different calcineurin ...
144
ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling
... increased calcineurin activity promotes adap- tation toward the slow myogenic program in response to physical demands, we investigated whether Actn3 KO muscles demonstrate greater changes in fiber size and ...
10
Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway
... and activity of calmodulin-dependent protein kinase II is modulated by zinc as well ...the activity of calcineurin in the early period of osteoclastogenesis of ...of calcineurin within 30 to ...
12
Calsarcin 2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation
... of calcineurin activity, we previously performed a yeast 2-hybrid assay using the regulatory subunit of calcineurin A as ...chronic calcineurin activation with excessive hypertrophy and ...
12
Genetic Interaction Between Calcineurin and Type 2 Myosin and Their Involvement in the Regulation of Cytokinesis and Chloride Ion Homeostasis in Fission Yeast
... required calcineurin activity for its growth approximately threefold increased frequency of medial and contractile ring ...Fifth, calcineurin-null rings or spots, which were stained by GFP-Cdc4, GFP- ...
11
Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
... to calcineurin [174], and human CABIN1 2143-2220 overexpression in Jurkat T cells inhibits NFATc dephosphorylation and NFAT-dependent luciferase expression ...of calcineurin activity (also named ...
19
Calcineurin-Binding Protein Cbp1 Directs the Specificity of Calcineurin-Dependent Hyphal Elongation during Mating in Cryptococcus neoformans
... by calcineurin, a serine-threonine-specific calcium-activated phosphatase that is the target of the immunosuppressive drugs cyclosporine A and ...a calcineurin binding protein (Cbp1, Rcn1, Dscr1/Csp1-3/ ...
13
The Calcineurin Pathway Inhibitor Tacrolimus Enhances the In Vitro Activity of Azoles against Mucorales via Apoptosis
... Since calcineurin- inhibiting agents have been extensively used in humans, it may be possible to manipulate this pathway, in order to develop novel strategies for recalcitrant fungal infections, such as ...
10
Calcineurin-Crz1 Signaling in Lower Eukaryotes
... of calcineurin. It was recently shown that impairment of calcineurin function in mice leads to increased branching of dendrites (inhibition of calcineurin [109]) or to a decrease in den- FIG 2 ...
12
The role of myostatin and the calcineurin signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum
... The calcineurin signaling pathway is thought to be one of several intracellular pathways in higher vertebrates that regulate hypertrophic growth of skeletal muscle (Musaro et ...vivo calcineurin inhibition ...
8
Topical calcineurin inhibitors in systemic lupus erythematosus
... topical calcineurin inhibitors, tacrolimus and pimecrolimus, have been used to treat resistant cutaneous lupus since 2002 and inhibit the proliferation and activation of T-cells and suppress immune-mediated ...
7
Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus
... The calcineurin pathway is an important signal transduction cascade required for T-cell activation and the target for the immunosuppressants cyclosporine A and FK506 (9, ...subunit. Calcineurin is also a ...
13
The Calcineurin Inhibitor Sparing (CIS) Trial individualised calcineurin inhibitor treatment by immunomonitoring in renal allograft recipients: protocol for a randomised controlled trial
... Recently, a new quantitative analysis of gene expression was employed to measure directly the functional effects of calcineurin inhibition: the transcriptional activities of NFAT-regulated genes in the peripheral ...
10
Treating pediatric atopic dermatitis: current perspectives
... Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of ran[r] ...
7
The role of the guanine nucleotide binding proteins p21ras in T cell activation and growth
... this activity alone does n o t account for the rate of nucleotide hydrolysis seen on Ras in ...is activity several h u n d re d ...pon activity(4, 46, 207). H ow ever, GAP activity is ...
244