Calcineurin Pathway
The Calcineurin Pathway Inhibitor Tacrolimus Enhances the In Vitro Activity of Azoles against Mucorales via Apoptosis
... The calcineurin pathway has been shown to be impor- tant for survival of pathogenic fungi, because of its central role in various cell processes, including morphogenetic transition and the development of ...
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Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans
... three calcineurin downstream targets Pbp1, Tif3, and Puf4, identified by a phospho-proteomic study, are involved in ...the calcineurin pathway may govern unisexual and bisexual reproduction in these ...
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The calcineurin pathway links hyperpolarization (Kir2 1) induced Ca2+ signals to human myoblast differentiation and fusion
... As calcineurin is a Ca 2+ -dependent phosphatase involved in human myoblast differentiation, we tested whether its activity is controlled by a Ca 2+ signal that could be induced by the ...assess calcineurin ...
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Regulation of ENA1 Na+-ATPase Gene Expression by the Ppz1 Protein Phosphatase Is Mediated by the Calcineurin Pathway
... of calcineurin activ- ity mentioned ...of calcineurin (when phosphorylated by ...which calcineurin activity would already be abnormally increased due to the absence of the Ppz1 phospha- ...of ...
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Components of the Calcium-Calcineurin Signaling Pathway in Fungal Cells and Their Potential as Antifungal Targets
... and calcineurin-mediated fungal resistance to fungicides constitutes cause for ...of calcineurin (111) to exhibit antifungal activity against Cryptococcus neoformans (112, 113), which identified ...
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Calcineurin Regulation in Fungi and Beyond
... of calcineurin regulation during pathogenesis by elucidating calcineurin-dependent pathway- specific functions of Rcn1 that may partially account for or- ganism ...the calcineurin-dependent ...
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A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis
... the calcineurin/NFAT pathway in the specification of the adult muscle fiber type that is no more debated, little is known about its involvement in the establishment of the muscle phenotype, particularly ...
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Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
... For calcineurin pathway experiments, the calcineurin inhibitor FK506 (2 mg/kg body weight per day) was given daily by intraperitoneal injection 24 hours after the minipump was implanted until mice ...
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Role of Retrograde Trafficking in Stress Response, Host Cell Interactions, and Virulence of Candida albicans
... the calcineurin pathway targets Crh11 and Utr2 is a key compensatory response in ...the calcineurin stress response pathway ...this pathway is activated as a compensatory response to ...
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SFRP2 Is Associated with Increased Adiposity and VEGF Expression
... calcineurin pathway and inhibition of angiogenesis with antibody to sFRP2 [17] provide a clue to the link between adipose, insulin secretion and sFRP2; the calcineurin inhibitor tacrolimus inhibits ...
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Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
... identified calcineurin as the common target of both compounds if and only if they are complexed with the respective endogenous partners, the ...the calcineurin/calmod- ulin protein from cellular ...active ...
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The role of the guanine nucleotide binding proteins p21ras in T cell activation and growth
... at calcineurin, w hich is regulated by increases in cytosolic calcium, is essential for TCR signalling function(52, 117, 246, 293, 302, ...active calcineurin in both a hum an leukaem ic T cell line, Jurkat, ...
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A Novel Resistance Pathway for Calcineurin Inhibitors in the Human Pathogenic Mucorales Mucor circinelloides
... Mucorales. Calcineurin is a conserved vir- ulence factor in many pathogenic fungi, and calcineurin inhibition or deletion of the calcineurin regulatory subunit (CnbR) in Mucor results in a shift from ...
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Roles for Stress Response and Cell Wall Biosynthesis Pathways in Caspofungin Tolerance in Cryptococcus neoformans
... and calcineurin signaling in this organism, but we suggest a deeper mechanism in which caspofungin tolerance is mediated by multiple pathways downstream of calcineurin ...
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Calcineurin-Binding Protein Cbp1 Directs the Specificity of Calcineurin-Dependent Hyphal Elongation during Mating in Cryptococcus neoformans
... by calcineurin, a serine-threonine-specific calcium-activated phosphatase that is the target of the immunosuppressive drugs cyclosporine A and ...a calcineurin binding protein (Cbp1, Rcn1, Dscr1/Csp1-3/ ...
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The role of myostatin and the calcineurin signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum
... The calcineurin signaling pathway is thought to be one of several intracellular pathways in higher vertebrates that regulate hypertrophic growth of skeletal muscle (Musaro et ...vivo calcineurin ...
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A regulatory pathway involving retinoic acid and calcineurin demarcates and maintains joint cells and osteoblasts in regenerating fin
... hoxa13a. Calcineurin activity, potentially through the inhibition of retinoic acid signaling, regulates evx1, pthlha and hoxa13a expression during joint ...regulatory pathway essential for joint formation ...
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Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae
... We next tested whether Cnb1 mutants exhibited reduced calcineurin activity in response to mating pheromone. Haploid yeast cells of opposite mating type sense each other through plasma membrane receptors, grow ...
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Treating pediatric atopic dermatitis: current perspectives
... and calcineurin inhibi- tors showed a rapid antipruritic effect and are effective to help to break the itch-scratch cycle when applied soon after onset of ...
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Topical calcineurin inhibitors in systemic lupus erythematosus
... The literature was systematically reviewed for all the articles involving topical calcineurin inhibitors by using the Medline search database. Search terms included tacrolimus, pimecrolimus, cutaneous lupus ...
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