calcitonin receptor
Lymphatic deletion of calcitonin receptor–like receptor exacerbates intestinal inflammation
... Adrenomedullin (AM) is a small multifunctional peptide that signals through a heterodimer of a GPCR, calcitonin receptor–like receptor (gene = CALCRL, protein = CLR), and receptor ...
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Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish
... the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signalling during arteriovenous ...
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Identification of the calcitonin receptor in osteoarthritic chondrocytes
... The results presented here allow us to conclude that human cartilage does express the calcitonin receptor. The main reason why other studies failed to find similar results may be the cell phenotype used in ...
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Downregulation of calcitonin receptor mRNA expression by calcitonin during human osteoclast like cell differentiation
... of calcitonin is limited because patients become refractory to calcitonin after several days (the calcitonin "escape ...for calcitonin "escape" is ...controlling calcitonin ...
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Calcitonin receptor gene expression in K562 chronic myelogenous leukemic cells
... human calcitonin receptor (hCTR) gene in the chronic myelogenous leukemia cell line K562 was ...salmon calcitonin (sCT), but not amylin, caused an increase in intracellular levels of cAMP similar to ...
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Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen induced arthritis rat model
... Salmon calcitonin (sCT)—along with other teleost and avian calcitonins, ...and calcitonin receptor agonist (DACRA) and by possessing a markedly higher in vivo potency [14, ...(eel calcitonin ...
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Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line
... A human ovarian small cell carcinoma line (BIN-67) expresses abundant calcitonin (CT) receptors (CTR) (143,000 per cell) that are coupled, to adenylate cyclase. The dissociation constants (Kd) for the CTRs on ...
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Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone The first intracellular domain modulates ligand binding and signal transduction
... Two distinct calcitonin (CT) receptor (CTR)-encoding cDNAs (designated GC-2 and GC-10) were cloned and characterized from giant cell tumor of bone (GCT). Both GC-2 and GC-10 differ structurally from the ...
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Adrenomedullin increases fibroblast like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation
... CLR: calcitonin receptor- like receptor; ...RAMP: receptor activity-modifying proteins; RT: room temperature; VCAM-1: vascular cell adhesion ...
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Quantifying biased agonism of adenosine and calcitonin like receptors
... for receptor activation in more than 10 family A and B GPCRs (Hirata et al, 1994, Thomas III et al, 1995, Wu et al, 1997, Liu and Wu, 2003, Yu et al, 2005, Kleinau et al, ...µ-opioid receptor these changes ...
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Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium of knee osteoarthritis patients
... to receptor activity-modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor (CLR) ...CGRP/CGRP receptor signaling in synovial tissue plays an important role in OA ...its ...
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Gene variants of osteoprotegerin, estrogen-, calcitonin- and vitamin D-receptor genes and serum markers of bone metabolism in patients with Gaucher disease type 1
... Patients and methods: Fifty adult Caucasian patients with GD1/117 controls were genotyped for gene variants in the osteoprotegerin (TNFRSF11B; OPG), estrogen receptor alpha, calcitonin receptor ...
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Red pitaya juice supplementation ameliorates energy balance homeostasis by modulating obesity related genes in high carbohydrate, high fat diet induced metabolic syndrome rats
... adiponectin receptor 1; Apoa4, apolipoprotein A-IV; Brs3, bombesin-like receptor 3; C3, complement component 3; Calcr, calcitonin receptor; Cartpt, CART prepropeptide; cDNA, complementary DNA; ...
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Distribution of beta endorphin immunoreactivity in normal human pituitary
... staining in preabsorption studies. It thus appears that the immunoreactive calcitonin in human pituitary differs from that in thyroid C cells. Likewise, we could not demonstrate immunoreactive endorphin in any ...
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Endocrine paraneoplastic syndromes in patients with neuroendocrine neoplasms
... of calcitonin >10 pg/ml in patients with tumours known to be associated with ectopic calcitonin secretion, exclusion of other conditions related to high calcitonin levels (including normal thyroid ...
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Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment
... In agreement with previous data in rat and human tri- geminal ganglia [19,20], CLR and RAMP1 were mostly co-localized in trigeminal ganglion neurons, however, some neurons only expressed RAMP1, while CLR was rarely found ...
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Vitamin D Metabolism in Osteogenesis Imperfecta During Calcitonin Therapy
... The chronic effect of calcitonin may be in accord with the ob- servations of Lee et al6 that chronically elevated endogenous calcitonin does not appear to influence 1,25-(OH)2D synthesis[r] ...
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Calcitonin concentrations in patients with chronic kidney disease on hemodialysis in reference to parathyroidectomy
... Elevated calcitonin levels in hemodialysis patients are not a surrogate marker for hyperparathyroidism but for medullary thyroid ...stimulated calcitonin concentration greater than 100 pg/ ...unstimulated ...
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Characterization of the Immunochemical Forms of Calcitonin Released by a Medullary Thyroid Carcinoma in Tissue Culture
... immunoreactive material released by the tumor into tissue culture medium was further analyzed by gel electrophoresis in the presence of the protein denaturant 8 M urea, by gel chromatography after reduction and ...
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Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines
... CGRP: calcitonin gene-related peptide; CI: confidence interval; ET-1: endothelin-1; FHM: familial hemiplegic migraine; GPR14: G- protein coupled receptor; hUT2R: human receptor for U-II; ICHD- 3: ...
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