Calcium-activated potassium channels
Molecular heterogeneity of large-conductance calcium-activated potassium channels in canine intracardiac ganglia
... be expressed in canine ICG, and that the original transcripts will carry one or more insertions. Although at present we can- not define the exact combination of BKα splice variants in ICG, the anticipated portrait is ...
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Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels
... Fig. 3 Concentration-dependent effect of resveratrol on voltage-gated sodium currents. The cells were bathed in Ca 2+ -free, Tyrode's solution. a Functional expression of the voltage-gated sodium current in embryonic rat ...
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Exposure to sodium butyrate leads to functional downregulation of calcium-activated potassium channels in human airway epithelial cells
... Abstract Cystic fibrosis (CF) is caused by genetic muta- tions that lead to dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl - channel. The most common mutation, ΔF508, causes inefficient ...
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D'hoedt, Dieter (2005): Structure-function analyses of small-conductance, calcium-activated potassium channels. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... external potassium on toxin binding, the extracellular potassium concentration was lowered from 144 mM K + to 20 mM K + , by exchanging KCl with ...the activated rSK2 channels in an ...
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Targeting potassium channels to treat cerebellar ataxia.
... reduced potassium channel function contributes to altered membrane excitability resulting in impaired Purkinje neuron ...approved potassium channel activators were ...vating calcium-activated ...
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Small-conductance calcium-activated potassium type 2 channels (SK2, KCa2.2) in human brain
... (KCa2.2) channels are voltage-independent Ca 2? -activated K ? channels that regulate neuronal excitability in brain regions important for memory forma- ...SK2 channels in human brain by ...
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Small-conductance calcium-activated potassium (SK)
... these potassium currents in part account for the differences of the electro- physiological properties between PCs and ...the potassium voltage-gated channel subfamily E member 2 gene, than the ...of ...
The synthesis of ligands for the large conductance calcium activated potassium channel
... sensitive channels ( K a t p ) are weak inward rectifier channels that are an important link between cell metabolism and electrical ...sensitive channels the activity is possibly regulated by the ...
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Regulation of vascular ATP-sensitive potassium channels by calcium and inflammatory mediators
... BKca channels, since iberiotoxin and charybdotoxin, both highly potent and selective inhibitors of these channels partially reversed the vascular hyporeactivity in the same tissue (Taguchi et ...BKca ...
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The pharmacology of calcium and ATP-dependent potassium channels in erythrocytes and in smooth skeletal muscle
... Abstract Potassium channels are a diverse class of membrane proteins found in virtually all ...the calcium activated potassium channel found in mammalian ...and calcium entry ...
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ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
... ion channels may be engaged once mu-opioid receptors is activated with morphine (Freye & Latasch, 2003; Koch & Hollt, 2008; Liu & Anand, ...ion channels may underlie the altered analgesic ...
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Calcium activated potassium channel of the tobacco hornworm, Manduca sexta: molecular characterization and expression analysis
... BK channels can participate in programmed cell death in vascular smooth muscle (Krick et ...and potassium efflux is a major component in neuronal apoptosis (Yu, 2003; Yu et ...
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The intermediate conductance calcium activated potassium channel KCa3 1 contributes to atherogenesis in mice and humans
... A key issue for any long-term therapy is the balance between efficacy and safety. Although blockade of KCa3.1 would appear to provide a good approach for atherosclerosis therapy, KCa3.1 is also present in many other cell ...
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The Contribution of Calcium-Activated Potassium Channel Dysfunction to Altered Purkinje Neuron Membrane Excitability in Spinocerebellar Ataxia
... may exist across SCAs with different underlying genetic causes. However, the extent of electrophysiologic dysfunction, including the contribution of K Ca channels or voltage- gated calcium channels, ...
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Original Article Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel
... reperfusion injury through mitoK Ca channels. Materials and methods: In the isolated perfused rat heart, myocardial ischemia/reperfusion injury was created by occlusion of the left anterior descending coronary ...
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Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels
... 3G43. potassium channel (Schumacher et ...of calcium chan- nels revealed a full repertoire of configurations including a dimer of dimers and the parallel orientation found with Ca V ...1.2 channels ...
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Exploring the biophysical evidence that mammalian two pore channels are NAADP activated calcium permeable channels
... pore channels, termed TPC1 and TPC2, are responsible for the NAADP-mediated Ca 2+ -release but the underlying mechanisms regulating their gating appear to be ...are activated by NAADP, TPC1 appears to be ...
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Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea
... Results ErbB TKIs amplify carbachol-induced current in intestinal cells. Because previous reports have implicated EGFR signaling in intestinal Cl – and fluid secretion (21, 22), we initially tested the effect of 2 ...
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Calcium channels and migraine
... 2.1 channels [126] ...P/Q channels [73] ...2.1 channels) play a key role in the positive feedback cycle that ignites CSD [73,127] ...2.1 channels in the initiation and propagation of CSD ...
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Calexcitin: A signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability
... Intradendritic recordings from Purkinje cell dendrites were obtained by advancing a glass microelectrode (Leitz micromanip- ulator) through the molecular layer of slices. Recordings were made up until 8 h after animals ...
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