calcium / calmodulin kinase II
Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... A β : Amyloid- β ; AD: Alzheimer ’ s disease; A η : Amyloid- η ; AMPAR: α -amino-3- hydroxyl-5-methyl-4-isoxazole-propionate receptor; APP: Amyloid precursor protein; CA1/3: Cornu Ammoni[r] ...
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Neocortical long-term potentiation and experience-dependent synaptic plasticity require alpha-calcium/calmodulin-dependent protein kinase II autophosphorylation
... Electrodes, stimulus, and recording. Glass-insulated carbon fiber micro- electrodes were used to record from the cortex (Armstrong-James et al., 1980). Vibrissas were stimulated at 0.1 Hz using a computer-controlled ...
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Characterization of a Toxoplasma gondii calcium calmodulin dependent protein kinase homolog
... the kinase activity we detected in these experiments was caused by a contaminating ki- nase(s) that physically associates with GST-TgCaMKrk, or that it was non-specifically selected for by the ...
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Calcium/Calmodulin-Dependent Protein Kinase II Regulates Caenorhabditis elegans Locomotion in Concert With a Go/Gq Signaling Network
... Our quantitative analysis of the unc-43 ( gf ) single mutants, rather than like unc-43 ( null ): the double suppression is consistent with this model since our data mutants are about as [r] ...
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Calcium/calmodulin dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes
... Pthrp antagonizes CamkII activity The finding that noncanonical Wnt signaling antagonizes endogenous CamkII activation fails to explain one key observation – that daCamkII expression in [r] ...
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Calcium/calmodulin dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways
... ER stress–induced apoptosis is implicated in various pathological conditions, but the mechanisms linking ER stress–mediated signaling to downstream apoptotic pathways remain unclear. Using human and mouse cell culture ...
18
Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice
... α -CaMKII: α -calcium/calmodulin-dependent protein kinase II; ACSF: Artificial cerebrospinal fluid; cEPOR: Constitutively active EPOR; ERK 1/2: RAS/extra- cellular signal-regulated kinas[r] ...
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A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
... CaMKII: Calcium/calmodulin-dependent protein kinase II; cFC: contextual fear conditioning; CKO: Conditional knockout; Cont: Control; CS: Conditioned stimulus; DG: Dentate gyrus; DMSO: Dimethyl ...
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Tight regulation of wingless type signaling in the articular cartilage subchondral bone biomechanical unit: transcriptomics in Frzb knockout mice
... Abbreviations Acta2: actin, alpha 2, smooth muscle, aorta; BMP: bone morphogenetic protein; CamKII: calcium/calmodulin-dependent protein kinase II; c-myc: vmyc myelocytomatosis viral onc[r] ...
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The role of tau in neurodegeneration
... AD: Alzheimer's disease; APP: amyloid precursor protein; CaMKII: calcium- and calmodulin-dependent protein kinase II; Cdk5: cyclin-dependent kinase-5; FTDP-17: frontal temporal dementia [r] ...
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Journal of Applied Pharmaceutical Science
... that calcium mediated secondary messengers play a crucial role in the mechanism of addictive process and oxidative stress induced by chronic opioid ...usage. Calcium/calmodulin-dependent protein ...
6
Calcium signaling around Mitochondria Associated Membranes (MAMs)
... through calmodulin (CaM); other modulators include phosphorylation by Ca 2+ /CaM-dependent kinase II (CaMKII), cGMP-depen- dent protein kinase (PKG), protein kinase C (PKC), and ...
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Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats
... multifunctional kinase CaMKIIδ has emerged as a key nodal point in the translation of cellu- lar stresses into downstream alterations to cardiac physi- ology [5, 11, ...
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Calcium and mitosis entry in the early sea urchin embryo
... of calcium-sensitive dyes, together with injections close to NEB, I minimised internalisation of these ...mitotic calcium transients from around 20% to ...NEB calcium transient strongly suggests that ...
207
CAMKII as a therapeutic target for growth factor–induced retinal and choroidal neovascularization
... revealed a role for this kinase in modulating ion homeostasis, nitric oxide production, and agonist‑in‑ duced changes in vascular permeability (17). We have previously reported that CAMKII acts as a key signaling ...
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Abnormalities of T cell signaling in systemic lupus erythematosus
... Lipid rafts are sphingolipid-cholesterol-GM1-rich micro- domains bearing TCR-CD3 complexes and associated signaling molecules distributed on the T cell surface. In normal T cells, TCR stimulation leads to clustering of ...
10
Toward transcriptional therapies for the failing heart: chemical screens to modulate genes
... cyclin-dependent kinase 9 signaling was recently shown to be associ- ated with repression of MEF2-mediated PGC-1 expression ...axis Kinase cascades can certainly regulate cardiac gene expression through ...
10
Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect
... and II), tetraspanins (CD9, CD63, CD81, and CD82), proteins involved in structure construction (like tubulin, actin, and filament actin), cytoplasmic proteins (such as annexins, Rab proteins, flotillin, Alix, and ...
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Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis
... Finally, Si et al. described a biochemical/functional interaction between the Ca 2+ /calmodulin-dependent pro- tein kinases (CaMKs) and RARs that modulates the differentiation of myeloid leukemia cells [118]. They ...
15
Ca2+/calmodulin dependent protein kinase II regulates cardiac Na+ channels
... In heart failure (HF), Ca 2+ /calmodulin kinase II (CaMKII) expression is increased. Altered Na + channel gating is linked to and may promote ventricular tachyarrhythmias (VTs) in HF. ...
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