calcium handling
Calcium handling by the mammalian kidney
... dietary calcium intake of 1000mg, net intestinal absorption amounts to about 200mg, with the remaining 800mg being excreted in the ...filtered calcium load (Costanzo and Windhager, ...the handling of ...
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Splicing Factor RBM20 Regulates Transcriptional Network of Titin Associated and Calcium Handling Genes in The Heart
... of calcium handling and sarcomeric structure ...validated calcium handling genes Trdn and Casq1 with fold changes, while other genes (RyR2, Serca2a and phospholamban/PLN) that have no fold ...
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MED12 regulates a transcriptional network of calcium-handling genes in the heart
... control, NFκB did not bind to or co-occupy the conserved CEBP, MEF2, CREB, EGR1, STAT3, or STAT1 consensus sites on Atp2a2, Gja1, Ryr2, Pln, or Cacna1d with MED12 (Supplemental Figure 4, F and G). Our results confirm ...
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Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function
... Previous work has shown that exposing ventricular myocytes to higher doses of LPS for 24 hours is suf- ficient to reduce contractility (34). We used lower doses of LPS and early time points to identify the initiating ...
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Differences in locomotor performance between individuals: importance of parvalbumin, calcium handling and metabolism
... Animal morphology directly affects the biomechanics of locomotion (Webb and Weihs, 1983; Lauder, 2005; Langerhans and Reznick, 2008). Within species, however, differences in the morphology of the skeletal system pose ...
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Role of intracellular calcium handling in force interval relationships of human ventricular myocardium
... intracellular calcium handling and availability to alterations in the strength of contraction produced by changes in stimulation rate and ...intracellular calcium and in the peak amplitude of the ...
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Glycolytic inhibition: effects on diastolic relaxation and intracellular calcium handling in hypertrophied rat ventricular myocytes
... intracellular calcium handling in well-oxygenated hypertrophied adult rat myocytes compared with control ...free calcium concentration ([Ca2+]i) with indo-1 in isolated paced myocytes from ...
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LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force
... and calcium handling, we used mouse primary myotube ...and calcium signaling (CAMK2B, ...and calcium handling ...after calcium and β-adrenergic stimulation and it has been shown ...
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Variation in expression of calcium handling proteins is associated with inter individual differences in mechanical performance of rat (Rattus norvegicus) skeletal muscle
... of calcium-handling ...reticulum calcium ATPase (SERCA)1 protein concentration, total SERCA activity, and mRNA concentrations of SERCA1, SERCA2, troponin I and ryanodine ...
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Abnormal Calcium Handling and Exaggerated Cardiac Dysfunction in Mice with Defective Vitamin D Signaling
... compared to Sham. #, p,0.05 compared to vehicle TAC. N = 8–10. (C) Representative Masson-Trichrome heart staining in 1a-OHase 2/2 mice with or without PC treatment after 4 weeks of sham or TAC. (D and E) Real-time PCR ...
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Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy
... example, this phenomenon has been observed with atrial fibrillation [30], during experimental heart fail- ure [31, 32], and in children with congenital heart dis- ease [33]. Alternatively, this compartment differential ...
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Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes
... in these cells have random structures within the cytoplasm, with no discernable A, I and Z bands [17]. Instead, immature Z-bodies joining clusters of adjacent sarcomeres are often found in hESC-CMs [14,17]. Sarcomeric ...
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Cardiac calcium handling in the mouse model of Duchenne Muscular Dystrophy
... the calcium sensitivity of the myofilaments, and/or a deterioration of the calcium signals due to dysfunction in one of the calcium handling proteins (Niggli, ...intracellular calcium ...
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Cardiac calcium handling in the mouse model of Duchenne Muscular Dystrophy
... affect calcium handling in cardiac myocytes ...L-type calcium channel antagonists on time to 90% relaxation (TR 90 ) in the tissue bath studies ...
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Pharmacological control of neutrophil-mediated inflammation: Strategies targeting calcium handling by activated polymorphonuclear leukocytes
... On the other hand, exposure of the cells to Ca 2 + -mobilizing activators of the oxidase, such as FMLP, is accompanied by effi cient clearance of store-derived cytosolic Ca 2 + , in the[r] ...
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No evidence for altered intracellular calcium-handling in airway smooth muscle cells from human subjects with asthma
... Our study has a number of potential limitations. We have used primary ASM cells and therefore whether important mechanisms present in vivo persist in culture is uncertain. However, our ability to observe hyper- ...
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NOX Inhibition Improves β-Adrenergic Stimulated Contractility and Intracellular Calcium Handling in the Aged Heart
... It is possible that in the aged rat heart, both isoforms may have contributed to the increased oxidative stress, since apocynin completely recovered ventricular f[r] ...
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Woodpecker drumming behavior is linked to the elevated expression of genes that encode calcium handling proteins in the neck musculature
... With these considerations in mind, we hypothesize that increased PV and SERCA1 expression in the woodpecker LC muscle is the result of sexual selection for effective drumming behavior. Faster and longer drums appear to ...
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Altered Calcium Handling in Peripheral Nerve Terminals and Blood Vessels in Spontaneously Hypertensive Rats
... intracellular calcium store size, the effects of ryanodine on pressor response and caffeine-induced vascular con- traction were also ...N-type calcium channels but not P/Q-type calcium channels play ...
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Friedreich's ataxia induced pluripotent stem cell derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency
... (30-40 beat per minute, Fig. 3A) which were slower than control cardiomyocytes. All lines showed similar corrected extracellular field potential durations (cFPD, Fig. 3B). We assessed the root of the mean of the sum of ...
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