Calcium-Sensing
Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism
... Acquired hypoparathyroidism (AH) has been considered to result from an autoimmune process but the self-antigens have not been identified. We studied 25 patients with AH, of which 17 had type I autoimmune polyglandular ...
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A novel mutation in the calcium sensing receptor gene in an Irish pedigree showing familial hypocalciuric hypercalcemia: a case report
... the calcium-sensing receptor (CaSR) gene in the majority of cases ...The calcium sensing receptor (CaSR) is a G-protein-coupled receptor of 1078 amino acids (AAs) with a large extracellular ...
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Extracellular calcium sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosis
... was significantly lower (p<0.01) than in control siRNA-A transfected cells. Similarly, we observed a dramatic reduction in ERK1,2 activation in cells treated with either PD98059 or U73122 and neomycin, when compared ...
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Functional characterization of calcium sensing receptor mutations expressed in human embryonic kidney cells
... three different classes of inactivating CaR mutants may exist. First, two of the mutations (R680C and P747fs) associated with FBH and NSHPT gave no response to either calcium or gado- linium. The P747fs mutation ...
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The calcium sensing receptor regulates mammary gland parathyroid hormone–related protein production and calcium transport
... and calcium trans- port into milk in vivo. Lactating mice fed a calcium- restricted diet appeared to produce less milk that was more viscous than that of their counterparts fed a nor- mal ...maternal ...
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The Ruler Protein EscP of the Enteropathogenic Escherichia coli Type III Secretion System Is Involved in Calcium Sensing and Secretion Hierarchy Regulation by Interacting with the Gatekeeper Protein SepL
... Extracellular calcium spike reversibly alters the secretion ...a calcium spike for 45 min resulted in a dramatic reduction of effector secretion and elevation of translo- cator secretion (lane 5 versus lane ...
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Expression of the calcium sensing receptor on human antral gastrin cells in culture
... extracellular calcium-sensing receptor on human antral gastrin cells was ...cell calcium-sensing ...extracellular calcium levels from ...the calcium receptor, spermine also ...
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Original Article The effects of calcium-sensing receptor (CASR) gene variants on colorectal cancer (CRC) risk and mortality: a systematic review and meta-analysis
... [11] Jenab M, McKay J, Bueno-de-Mesquita HB, van Duijnhoven FJ, Ferrari P, Slimani N, Jansen EH, Pischon T, Rinaldi S, Tjønneland A, Olsen A, Overvad K, Boutron-Ruault MC, Clavel- Chapelon F, Engel P, Kaaks R, Linseisen ...
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SINGLE NUCLEOTIDE POLYMORPHISMS OF CALCIUM SENSING RECEPTOR ENCODING GENE ASSOCIATED WITH CALCIUM KIDNEY STONE DISEASE IN BABYLON PROVINCE
... containing calcium. A change of kidney systems of calcium eliminations is the foremost cause for ...reduction calcium reabsorption renal tubules and hypercalciuria caused by defeating the action of ...
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Calcium sensing receptor activation increases cell cell adhesion and ß cell function
... extracellular calcium sensing receptor (CaR) plays a central role in maintaining systemic Ca 2+ -homeostasis by regulating the secretion of parathyroid hormone and urinary calcium concentration ...
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The calcium sensing receptor and insulin secretion : a role outside systemic control 15 years on
... extracellular calcium-sensing receptor (CaR; Brown et ...systemic calcium regulation (extensively reviewed in Brown ...free calcium ion concentration is not restricted to tissues involved in ...
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A role for the extracellular calcium sensing receptor in cell cell communication in pancreatic islets of Langerhans
... in sterile PBS and serum starved for 2hrs in fresh DMEM containing glucose (5.5mM) and nominal calcium (0.25mM) before a final 3hr incubation in media containing various concentrations of calcium (0, 0.5 ...
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Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium-sensing receptor
... This is the peer reviewed version of the following article: Chamberlin, M. , Kemp, E. H., Weetman, A. P., Khadka, B. and Brown, E. M. (2018), Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with ...
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The calcium sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
... urinary calcium excretion varied widely in mice lacking ...serum calcium levels within a narrow range in the absence of PTH is unclear, but this model should be useful for more detailed stud- ies of CaR ...
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Parathyroid Embryology, Anatomy, and Pathophysiology of Primary Hyperparathyroidism
... the calcium sensing receptor gene have resulted in the confirmation of the key role that the calcium sensing receptor plays in calcium homeostasis [88] ...the calcium ...
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Regulation of murine fetal placental calcium metabolism by the calcium sensing receptor
... ionized calcium level of CaSR 2/2 fe- tuses was no higher than that of the CaSR 1/2 littermates, in contrast to the striking elevation seen in CaSR 2/2 pups, and in human neonates with neonatal severe primary ...
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Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium sensing receptor deficient mice
... The calcium-sensing receptor (CaR; CASR – Mouse Genome Informatics) is a plasma membrane G-protein-coupled receptor that is activated by extracellular ...systemic calcium homeostasis, predominately ...
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Phenytoin Induced Elevation of the Intracellular Calcium Concentration by Stimulation of Calcium Sensing Receptors in Gingival Fibroblasts
... al. [7] also proposed the increase in fibroblast prolifera- tion. In contrast, Fujimori et al. [8] reported that a re- duced rate of apoptosis contributes to the accumulation of gingival fibroblasts. On the hand, as the ...
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Role of Ca2+ and L-Phe in Regulating Functional Cooperativity of Disease-Associated "Toggle" Calcium-Sensing Receptor Mutations
... mutations studied here are located in the hinge region near the predicted calcium- binding site 1, which is located between lobe 1 and lobe 2. Meanwhile they are also adjacent (within 10 A˚) to the reported L-Phe ...
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A New Way of Sensing: Need Based Activation of Antibiotic Resistance by a Flux Sensing Mechanism
... intracellular sensing mechanism, the opposite behavior is ex- pected: cells with a high level of BceAB should respond more sen- sitively than those with few transporters, as the total amount of bacitracin ...
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