calcium‐sensing receptor
Role of Receptor Activity Modifying Protein 1 in Function of the Calcium Sensing Receptor in the Human TT Thyroid Carcinoma Cell Line
... The Calcium Sensing Receptor (CaSR) plays a role in calcium homeostasis by sensing minute changes in serum Ca 2+ and modulating secretion of calciotropic ...as Receptor Activity ...
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A novel mutation in the calcium sensing receptor gene in an Irish pedigree showing familial hypocalciuric hypercalcemia: a case report
... the calcium-sensing receptor (CaSR) gene in the majority of cases ...The calcium sensing receptor (CaSR) is a G-protein-coupled receptor of 1078 amino acids (AAs) with a ...
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Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism
... Acquired hypoparathyroidism (AH) has been considered to result from an autoimmune process but the self-antigens have not been identified. We studied 25 patients with AH, of which 17 had type I autoimmune polyglandular ...
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Extracellular calcium sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosis
... Recent evidence also suggests that a functional CaSR is expressed in vascular SMC. Wonneberger et al. [12] and Ohanian et al. [13] demonstrated the expression of a functional CaSR involved in the regulation of myogenic ...
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Expression of the calcium sensing receptor on human antral gastrin cells in culture
... (19). The immunostaining of the gastrin cells by the CaR anti- body demonstrated both an intense immunoreactivity in the region containing the secretory granules, and staining of the presumptive apical region. This ...
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The calcium sensing receptor and insulin secretion : a role outside systemic control 15 years on
... using receptor-specific calcimimetics (reviewed in Trivedi et ...of calcium- rich secretory granules feeds forward to synchronise secretion and perpetuate the whole islet ...
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A role for the extracellular calcium sensing receptor in cell cell communication in pancreatic islets of Langerhans
... in sterile PBS and serum starved for 2hrs in fresh DMEM containing glucose (5.5mM) and nominal calcium (0.25mM) before a final 3hr incubation in media containing various concentrations of calcium (0, 0.5 ...
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SINGLE NUCLEOTIDE POLYMORPHISMS OF CALCIUM SENSING RECEPTOR ENCODING GENE ASSOCIATED WITH CALCIUM KIDNEY STONE DISEASE IN BABYLON PROVINCE
... Method: The blood samples were collected from 100 patients and divided into two groups, each one containing 50 samples; chronic kidney disease and end-stage renal disease, who admitted Merjan Teaching Hospital in Babylon ...
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Functional characterization of calcium sensing receptor mutations expressed in human embryonic kidney cells
... of receptor function, as found in the type 2 vasopressin and the adrenocor- ticotropin receptors in the disorders of X-linked nephrogenic diabetes insipidus and familial glucocorticoid deficiency, re- spectively ...
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The calcium sensing receptor regulates mammary gland parathyroid hormone–related protein production and calcium transport
... and calcium trans- port into milk in vivo. Lactating mice fed a calcium- restricted diet appeared to produce less milk that was more viscous than that of their counterparts fed a nor- mal ...maternal ...
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Original Article The effects of calcium-sensing receptor (CASR) gene variants on colorectal cancer (CRC) risk and mortality: a systematic review and meta-analysis
... [11] Jenab M, McKay J, Bueno-de-Mesquita HB, van Duijnhoven FJ, Ferrari P, Slimani N, Jansen EH, Pischon T, Rinaldi S, Tjønneland A, Olsen A, Overvad K, Boutron-Ruault MC, Clavel- Chapelon F, Engel P, Kaaks R, Linseisen ...
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Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium sensing receptor deficient mice
... The calcium-sensing receptor (CaR; CASR – Mouse Genome Informatics) is a plasma membrane G-protein-coupled receptor that is activated by extracellular ...systemic calcium homeostasis, ...
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Parathyroid Embryology, Anatomy, and Pathophysiology of Primary Hyperparathyroidism
... the calcium sensing receptor gene have resulted in the confirmation of the key role that the calcium sensing receptor plays in calcium homeostasis [88] ...the ...
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The calcium sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
... spine. Since multiple hypotheses were tested in the course of the various studies described in this paper, we acknowledge the possibility that this result may repre- sent a “false positive,” particularly given the P ...
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Calcium sensing receptor activation increases cell cell adhesion and ß cell function
... extracellular calcium sensing receptor (CaR) plays a central role in maintaining systemic Ca 2+ -homeostasis by regulating the secretion of parathyroid hormone and urinary calcium ...
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Characterisation of C terminal RyR1 variants linked to neuromuscular disorders : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, Manawatū, New Zealand
... of calcium by defective RyR1 channels – located in the calcium storage organelle membrane – but both are complex disorders with variable penetrance and genetic ...
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Role of Ca2+ and L-Phe in Regulating Functional Cooperativity of Disease-Associated "Toggle" Calcium-Sensing Receptor Mutations
... intracellular calcium responses) and disrupt regulation of PTH secretion from the parathyroid chief cell and Ca 2+ reabsorption in the renal tubule. Mutations that inactivate CaSR (i.e., result in ...
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Association of medullary sponge kidney and hyperparathyroidism with RET G691S/S904S polymorphism: a case report
... hormone (PTH) 1147 pg/ml (Table 1), 25-hydroxyvitamin D3 level 42.98 nmol/L with reference range (RR) of 47.7– 144 nmol/L, 24-hour urinary calcium 8.98 mmol/day (RR, 2.5–7.5 mmol/day), and 24-hour urine potassium ...
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Reversible Signal Binding by the Pseudomonas aeruginosa Quorum Sensing Signal Receptor LasR
... A cyl-homoserine lactone (acyl-HSL) quorum sensing controls a battery of genes involved in virulence of Pseudomonas aeruginosa (1, 2). This opportunistic pathogen has two acyl-HSL synthases, LasI and RhlI, which ...
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Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium-sensing receptor
... This is the peer reviewed version of the following article: Chamberlin, M. , Kemp, E. H., Weetman, A. P., Khadka, B. and Brown, E. M. (2018), Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with ...
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