Calcium-sensing receptor (CaR)
The calcium sensing receptor regulates mammary gland parathyroid hormone–related protein production and calcium transport
... of calcium from mother to milk during lactation is poorly ...and calcium trans- port in mammary epithelial cells are regulated by extracellular calcium acting through the calcium- ...
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Homology Modeling of the Calcium Sensing Receptor Extracellular Domain
... extracellular calcium sensing receptor was obtained from the EXPASY server ...of CaR was ...between CaR and the template proteins using MODELLER 9v2 ...
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Calcium sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism
... of calcium homeostasis that are associated with missense mutations of the calcium-sensing receptor ...such CaR mutations in FBH and NHPT and to explore methods for their more rapid ...
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Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium sensing receptor deficient mice
... The calcium-sensing receptor (CaR; CASR – Mouse Genome Informatics) is a plasma membrane G-protein-coupled receptor that is activated by extracellular ...calcium. CaR ...
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Protein-induced satiation and the calcium-sensing receptor
... the calcium-sensing receptor has been identified in several cells of the GI tract, including L-cells, and suggested to sense specific amino ...the calcium-sensing receptor may be ...
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A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations
... Background: The role of mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene in chronic pancreatitis is still a matter of debate. Active SPINK1 is thought to antagonize activated trypsin. Cases of SPINK1 ...
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Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats
... feline calcium sensing receptor, in addition to four previously identified ...serum calcium concentrations (Scillitani et ...ionised calcium concentrations but no association with PTH ...
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Expression of the calcium sensing receptor on human antral gastrin cells in culture
... extracellular calcium-sensing receptor on human antral gastrin cells was ...cell calcium-sensing ...the receptor immuno- stained all gastrin cells (but not mucin or somatostatin ...
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Diseases associated with calcium-sensing receptor
... 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium- binding ...
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Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism
... Acquired hypoparathyroidism (AH) has been considered to result from an autoimmune process but the self-antigens have not been identified. We studied 25 patients with AH, of which 17 had type I autoimmune polyglandular ...
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Biological Function of Calcium-Sensing Receptor (CAS) and Its Coupling Calcium Signaling in Plants
... droughts tolerant due to excessive transpiration when grown under low soil moisture conditions [24]. In rice, the calcium-sensing receptor gene (OsCAS) is also closely associated with drought ...
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A novel mutation in calcium-sensing receptor gene associated to hypercalcemia and hypercalciuria
... of calcium-sensing receptor (CaSR) gene, involved in PTH regulation as well as in renal calcium ...a Calcium/Creatinine ratio of ...ionized calcium levels were close to the upper ...
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Calcium-sensing receptor gene (CASR) polymorphisms and CASR transcript level concerning dyslipidemia in hemodialysis patients: a cross-sectional study
... of calcium- sensing receptor gene (CASR) are predominantly asso- ciated with phenotypes of primary [4] and secondary hyperparathyroidism [5–8], and with idiopathic cal- cium nephrolithiasis [9, ...
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Extracellular calcium sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosis
... Abstract. Calcium-sensing receptor (CaSR) plays key role in vascular calcification in patients with chronic kidney disease (CKD). We investigated the role of CaSR in regulating smooth muscle cell ...
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Quantitative assessment of the clinical susceptibility of calcium-sensing receptor polymorphisms in cancer patients
... (“Calcium-Sensing Receptor” OR “CASR”) AND (“can- cer” OR “malignancies” OR “neoplasms” OR “tumor” OR “carcinoma”) AND (“polymorphism” OR “variation” OR “variant” OR “single nucleotide polymorphism” ...
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SINGLE NUCLEOTIDE POLYMORPHISMS OF CALCIUM SENSING RECEPTOR ENCODING GENE ASSOCIATED WITH CALCIUM KIDNEY STONE DISEASE IN BABYLON PROVINCE
... urine calcium levels, calcium supplements, certain foods, obesity, hyperparathyroidism, gout, some medications, and not drinking enough ...The calcium-sensing receptor (CASR) is a ...
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The calcium sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
... and CaR loci, four PCR ampli- fication reactions were required for each ...wild-type CaR allele, sam- ples were amplified with CaR forward primer CaR6h5 ′ (5 ′ TCT GTT CTC TTT AGG TCC TGA AAC A 3 ′ ) ...
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Calcium sensing receptor and calcium kidney stones
... These data suggest a physiopathological role of CaSR in protecting human tissues against the risk of calcifica- tion, a risk induced by the condition of supersaturation in body fluids. The functional importance of CaSR ...
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PTH independent regulation of blood calcium concentration by the calcium sensing receptor
... The last part of the study was directed at dissecting the mecha- nism by which CaSR acts on the renal tubule. We show here that CaSR in the kidney is exclusively restricted to the TAL. (Previous reports have shown ...
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Regulation of murine fetal placental calcium metabolism by the calcium sensing receptor
... ionized calcium level of CaSR 2/2 fe- tuses was no higher than that of the CaSR 1/2 littermates, in contrast to the striking elevation seen in CaSR 2/2 pups, and in human neonates with neonatal severe primary ...
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