Calcium-sensing receptor (CaSR)
Calcium-sensing receptor gene (CASR) polymorphisms and CASR transcript level concerning dyslipidemia in hemodialysis patients: a cross-sectional study
... of calcium- sensing receptor gene (CASR) are predominantly asso- ciated with phenotypes of primary [4] and secondary hyperparathyroidism [5–8], and with idiopathic cal- cium nephrolithiasis ...
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Original Article The effects of calcium-sensing receptor (CASR) gene variants on colorectal cancer (CRC) risk and mortality: a systematic review and meta-analysis
... of calcium-sensing receptor (CASR) in colorectal cancer (CRC) have been assessed with several studies, but the conclusions were ...of CASR polymorphisms on CRC risk and ...the ...
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The functional expression of extracellular calcium-sensing receptor in rat pulmonary artery smooth muscle cells
... Intracellular calcium, a secondary messenger, plays a key role in various physiological ...extracellular calcium can act as a first messenger through the calcium-sensing receptor ...
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Association between calcium-sensing receptor (CaSR) R990G, CaSR A986S, and CaSR Q1011E gene polymorphisms and the risk of urolithiasis: a meta-analysis
... between CaSR gene poly- morphisms (CaSR R990G, CaSR A986S, and CaSR Q1011E) and the risk of urolithiasis were searched in major scientific websites (PubMed, Embase, Cochrane, and Web of ...
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Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium sensing receptor deficient mice
... The calcium-sensing receptor (CaR; CASR – Mouse Genome Informatics) is a plasma membrane G-protein-coupled receptor that is activated by extracellular ...systemic calcium ...
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Quantitative assessment of the clinical susceptibility of calcium-sensing receptor polymorphisms in cancer patients
... the CASR polymorphisms and cancer risk, and published from their inception to April 2016, were identified by comprehensive searches of electronic databases, includ- ing Pubmed, EMBASE, Web of Science, China ...
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Homology Modeling of the Calcium Sensing Receptor Extracellular Domain
... the calcium-sensing receptor, (allosteric agonist) which leads to a different structural configuration that is more sensitive to serum ...serum calcium levels; therefore, adverse effects ...
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Protein-induced satiation and the calcium-sensing receptor
... acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism? Eur J Clin ...al. Calcium-sensing receptor is a ...
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Biological Function of Calcium-Sensing Receptor (CAS) and Its Coupling Calcium Signaling in Plants
... droughts tolerant due to excessive transpiration when grown under low soil moisture conditions [24]. In rice, the calcium-sensing receptor gene (OsCAS) is also closely associated with drought ...
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PTH independent regulation of blood calcium concentration by the calcium sensing receptor
... RNA was extracted according to the technique previously described (33) from nephron segments. RNA was reverse transcribed in 20 μl using the first-strand cDNA synthesis kit for RT-PCR (Roche Diagnostics), accord- ing to ...
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Calcium sensing receptor and calcium kidney stones
... animals, CaSR activation by serum-interstitial calcium enhanced the intracellular production of arachidonic acid and HETE that can inactivate the potassium ROMK channel and the Na-K-2Cl cotransporter ...
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Regulation of murine fetal placental calcium metabolism by the calcium sensing receptor
... the CaSR is also associated with a stepwise increase in the fetal serum PTH and 1,25-dihydroxyvitamin D levels, and increased excretion of cal- cium and free deoxypyridinoline into the amniotic ...the CaSR. ...
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Diseases associated with calcium-sensing receptor
... the CASR gene either heterozygous (autosomal dominant familial benign hypercalcaemia, still named hypocalciuric hypercalcaemia syndrome type 1) or homozygous (severe neonatal ...the CASR gene are associated ...
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Association Studies of Calcium-Sensing Receptor (CaSR) Polymorphisms with Serum Concentrations of Glucose and Phosphate, and Vascular Calcification in Renal Transplant Recipients
... Six CASR polymorphisms were selected for ...the CASR and three were non-synonymous SNPs located in the coding region of exon 7 (A986S (rs1801725), R990G (rs1042636) and Q1011E (rs1801726)) ...
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Activation of the calcium-sensing receptor attenuates TRPV6-dependent intestinal calcium absorption
... and CaSR-expressing oocytes in the presence of U73122 (5 μM), a PLC inhibitor, or in the presence of U73122 and ...the CaSR (Supplemen- tal Figure ...the CaSR-mediated decrease in TRPV6 activity ...
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Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo
... in calcium and bone homeostasis that have not been previously ...calcitonin receptor also have a phenotype of increased bone mass as adults ...skeletal calcium content as their wild-type sisters ...
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The calcium sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
... urinary calcium excretion varied widely in mice lacking ...serum calcium levels within a narrow range in the absence of PTH is unclear, but this model should be useful for more detailed stud- ies of CaR ...
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The importance of the thick ascending limb of Henle’s loop in renal physiology and pathophysiology
... the calcium sensing receptor (CaSR) signaling in the absence of changes in transepithelial volt- age suggested that paracellular permeability may vary, with consequent changes in divalent ...
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Successful treatment of neonatal severe hyperparathyroidism with cinacalcet in two patients
... Neonatal severe hyperparathyroidism (NSHPT) is a rare disorder caused by inactivating calcium-sensing receptor (CASR) mutations that result in life-threatening hypercalcemia and metabolic bone ...
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Case report: acute clinical presentation and neonatal management of primary hyperparathyroidism due to a novel CaSR mutation
... calcium-sensing receptor CaSR, whose gene is encoded in the long arm of chromosome 3 ...different CaSR inactivating mutations have been de- ...treatment. CaSR is a ...
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