calmodulin dependent kinase II
Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... It has been established that CaMKII is dysregulated in AD hippocampus (Fig. 1). We suggest that this dysregu- lation is a key contributor to synaptic degeneration, NFT formation and memory deficits. However, the nature ...
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A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats
... CaMKII: Ca 2 + /calmodulin-dependent kinase II; DAF-FM: 4-amino-5-meth- ylamino-2,7-difluorofluorescein; DAPA: dapagliflozin treatment; ± dP/dt: rates of pressure development and decay;[r] ...
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The Role of Ca2+/Calmodulin Dependent Protein Kinase II Alpha in Group 1 Metabotropic Glutamate Receptor Endocytosis and Signalling
... the generation of diacylglycerol and inositol phosphate (IP). CaMKIIα is a kinase that could contribute to the phosphorylation and desensitization of group I mGluR G protein coupling. We focused our investigation ...
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Investigation of neuronal cell type-specific gene expression of Ca2+/calmodulin-dependent protein kinase II
... CaM kinase II promoter-luciferase reporters were created by polymerase chain reaction (PCR) with cloned genomic DNA (CL-1 clone) (15) as a ...CaM kinase II gene (17) was digested with SalI and ...
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A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
... protein kinase II; cFC: contextual fear conditioning; CKO: Conditional knockout; Cont: Control; CS: Conditioned stimulus; DG: Dentate gyrus; DMSO: Dimethyl sulphoxide; ERK: Extracellular regulated ...
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Calcium/calmodulin dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways
... ER stress–induced apoptosis is implicated in various pathological conditions, but the mechanisms linking ER stress–mediated signaling to downstream apoptotic pathways remain unclear. Using human and mouse cell culture ...
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Calcium/calmodulin dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes
... is dependent on the relative strengths of Pthrp and Ihh signals, determines the maximum number of proliferative chondrocytes that can be generated from a single mother row cell because each daughter cell occupies ...
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Ca2+/calmodulin dependent protein kinase II regulates cardiac Na+ channels
... overexpression. CaMKII coimmunoprecipitates with and phosphorylates Na + channels. In vivo, transgenic CaMKIId C overexpression prolonged QRS duration and repolarization (QT intervals), decreased effective refractory ...
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Herbal formula GAPT prevents beta amyloid deposition induced Ca2+/Calmodulin dependent protein kinase II and Ca2+/Calmodulin dependent protein phosphatase 2B imbalance in APPV717I mice
... protein kinase II (CaMKII) and Ca 2+ /Calmodulin-dependent protein phosphatase 2B (calcineurin, CaN) have been found to play important roles in memory processes and neuronal degeneration ...
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Neocortical long-term potentiation and experience-dependent synaptic plasticity require alpha-calcium/calmodulin-dependent protein kinase II autophosphorylation
... The synaptic potentials tend to occur synchronously in the barrel cortex, because whisker stimulation can be made with rapid onset (1 msec) and at a discrete moment in time, producing a high level of temporal summation. ...
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Calcium and mitosis entry in the early sea urchin embryo
... CaM kinase II releases the egg from metaphase arrest at fertilisation (Lorca et ...with calmodulin degradation (Singh and Chatterjee, 1988; Uno ...
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Characterization of a Toxoplasma gondii calcium calmodulin dependent protein kinase homolog
... the kinase activity we detected in these experiments was caused by a contaminating ki- nase(s) that physically associates with GST-TgCaMKrk, or that it was non-specifically selected for by the ...
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Tong Luo Jiu Nao ameliorates Aβ1–40 induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
... signal-regulated kinase (ERK), Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and cAMP response element-binding protein (CREB) have been implicated in mediating Aβ induced ...
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Calcium signaling around Mitochondria Associated Membranes (MAMs)
... through calmodulin (CaM); other modulators include phosphorylation by Ca 2+ /CaM-dependent kinase II (CaMKII), cGMP-depen- dent protein kinase (PKG), protein kinase C (PKC), and ...
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Journal of Applied Pharmaceutical Science
... protein kinase II (CaMKII), is a major calcium regulated signal transducer that controls many neuronal systems and play important role in neuronal plasticity and can act as a key and direct promoting opioid ...
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CAMKII as a therapeutic target for growth factor–induced retinal and choroidal neovascularization
... responses in vitro and pathological neovascularization in the retina in vivo (48–52). Based on our in silico analyses, these proteins do not appear to be direct substrates of CAMKII’s catalytic activity, sug‑ gesting ...
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22697eb81f398b7abee832a39a01daec442f602b.pdf
... By contrast, for hDAPK1 there is a substantially higher level of diversity in terms of possible arrangements. Among the 30 deposited DAPK1 structures, we found three with an alternative dimer interface (PDB: 1JKT, 2Y4P, ...
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The role of tau in neurodegeneration
... tauopathies. For example, the expression of pseudophos- phorylated tau, which mimics disease-like tau hyperphos- phorylation, causes apoptosis in neuronal cells, an effect not observed when cells express wild-type tau ...
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An ensemble method approach to investigate kinase-specific phosphorylation sites
... To avoid biased prediction, we have considered a candidate site to be true positive only when the site is pre- dicted correctly. The comparison is done on the basis of the parameter’s precision, recall, accuracy, and ...
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p600 stabilizes microtubules to prevent the aggregation of CaMKIIα during photoconductive stimulation
... a proxy of neuronal death, via direct binding to calmodulin in a microtubule- independent manner. Using photoconductive stimulation coupled with live imaging of single neurons, we identified a distinct mechanism ...
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