Calpain-2
Original Article MicroRNA-137 inhibits apoptosis of neuron cells in injured spinal cord by targeting calpain 2
... The protective efficacy of miR-137 has previ- ously been demonstrated in vitro and in vivo in cardiac diseases by inhibiting cardiomyocyte apoptosis and suppressing various cancers [37, 38]. In this study, we extend our ...
8
Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway
... whether Calpain-2 could enhance the chemoresistance of NSCLC cells to PTX through the activation of ...of Calpain-2 led to high tendency to apoptosis induced by ...decreased ...
11
Calpain 2 expression pattern and sub cellular localization during mouse embryogenesis
... ABSTRACT Regulation of migration and proliferation by calpain has been shown in various cell types; however, no data are available concerning calpain 2 (CAPN2) localization in embryonic tissues. ...
7
Calpain 2 expression is associated with response to platinum based chemotherapy, progression free and overall survival in ovarian cancer
... anti- calpain-2 [all Chemicon (Millipore, MA, USA) clones PI-11, P-6 and rabbit polyclonal AB1625, respectively, with specificity confirmed by Western blotting] [17, ...1:15,000; calpain-1 1:2500; ...
7
Calpain 1 and 2 Are Required for RNA Replication of Echovirus 1
... for calpain 1 and 2, called calpeptin, and showed that it caused significant blocking of EV1 infection in cells ...vesicles 2 h ...of calpain inhibition on the infectivity of EV1, a plaque ...
10
Ischemic preconditioning attenuates ischemia/reperfusion injury in rat steatotic liver: role of heme oxygenase-1-mediated autophagy
... that calpain 2 hydrolyzes autophagy proteins [26, ...in calpain 2 activity ...prevent calpain 2-impaired autophagy by increasing ...
15
Calpain system protein expression in basal like and triple negative invasive breast cancer
... The calpain system has been implicated in various aspects of cancer progression, including migration and cell survival ...enhance calpain activation through reducing the concentration of calcium required, ...
8
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
... forms, calpain 1 and calpain 2, also known as μ-calpain and m-calpain, have been linked to Alzheimer disease (AD) ...of calpain 2 is increased in neurites of neurons at ...
13
Podocyte associated talin1 is critical for glomerular filtration barrier maintenance
... that calpain-mediated talin1 cleavage may play a critical role in the pathology resulting following podocyte ...by calpain decouples the intimate link between integrins at the GBM and the actin ...
17
2. Reviewed paper on biology of the Calpain proteolytic system
... μ- calpain and m-calpain, composed of 80 kDa reactant subunits, can also serve as a reliable point for the 28 kDa management ...and calpain, called calpain-1 and calpain-2, ...
7
Caspase 3 and caspase 8 expression in breast cancer: caspase 3 is associated with survival
... between calpain and caspase protein ...high calpain-2 expression is associated with worse prognosis in patients with basal-like or triple-negative diseases [23] and that cal- pain-1 expression is ...
12
Excess Nitric Oxide Activates TRPV1-Ca2+-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α
... S-nitroso-N-acetyl-D,L-penicillamine (SNAP), diethylenetriamine/nitric oxide (DETA/NO), 3-hexanoly-7- nitro-2,1,3-benzoxadial-4-yl (NBD) cholesterol, capsazepine (CPZ) and SB366791 were from Cayman Chemical (Ann Arbor, ...
12
Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis
... (Ca 2+ ) homeostasis can exacerbate many of the factors proposed to mediate muscle degeneration in IBM, such as mitochondrial dysfunction, protein aggregation, and endoplasmic reticulum ...Ca 2+ ...
11
Calpain inhibition ameliorates scald burn-induced acute lung injury in rats
... revealed calpain 1 and CD45 double-positive cells in the lungs of rats exposed to scald burn ...of calpain. As the calpain inhibitor MDL28170 gave no discernible pro- tection against burn-induced ...
9
Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease
... The demonstration of neuronal lysosomal disruption in sCJD made us speculate that release of lysosomal con- tent, especially Cathepsins, could be a key determinant on the neurotoxicity linked to prion diseases through ...
20
Association of some calpain 10 gene polymorphisms with the incidence of type 2 diabetes mellitus in iraq
... 2008).Type 2 diabetes mellitus (T2DM) is a multi-factorial metabolic syndrome, characterized by high blood glucose level, mainly caused by insulin resistance and relative insulin deficiency (Bonnefond et ...type ...
6
In Silico Structure Analysis of Type 2 Diabetes Associated Cysteine Protease Calpain 10 (CAPN10)
... involved in the cellular degenerative processes that characterize several diseases such as cancer, stroke and heart attack. The role of calpain10 was recently identified and associated with diabetes mellitus type ...
12
Neuroprotective strategies against calpain-mediated neurodegeneration
... abnormal calpain activation triggers activation and progression of apoptotic processes in neurodegeneration, leading to neuronal ...of calpain-mediated neurodegeneration in order to protect neurons through ...
14
Inhibition of calpain but not caspase activity by spectrin fragments
... Finally, we varied the concentration of spectrin fragments in the calpain reaction mixture. A clear concentration dependent effect was observed for αII-N1 (Fig. 1D). Furthermore, a longer spectrin fragment, ...
11
Bacterial calpains and the evolution of the calpain (C2) family of peptidases
... bacterial calpain homologues have only the peptidase domain; the embellishment with other domains happened mainly in the ...archaeon calpain homologues, and second, the limited distribution of ...
12