cAMP-dependent protein kinase
IDENTIFICATION OF HUMAN cAMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT INHIBITORS
... Conformational change is a common mechanism for kinases to orient a phosphoryl leaving group and to eliminate water from the active site 4 . Defective regulation of PKA holoenzyme activity is directly related to the ...
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THE EFFECT OF THEOPHYLLINE ON THE KINETICS OF cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT, cAMP, PROTEIN KINASE INHIBITOR AND THEIR RELATIONSHIP IN LUNG TISSUE
... of cAMP-dependent protein ...tllrough cAMP and recently many reports have indicated its involvement in ...of cAMP-dependent protein kinase at the ceUular level ...
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sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase.
... sckl, a High Copy Number Suppressor of Defects in the CAMP-Dependent Protein Kinase Pathway in Fission Yeast, Encodes a Protein Homologous.. to the Saccharomyces cer[r] ...
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Relationship of the cAMP-dependent protein kinase pathway to the SNF1 protein kinase and invertase expression in Saccharomyces cerevisiae.
... Suppression of the R a f phenotype is not due to restoration of invertase expression: T h e snfl and snf4 mutants are defective i n growth on raffinose at least i n [r] ...
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Proteomic Analysis of Celecoxib on Chondrocytes from Patients with Osteoarthritis
... shock protein 47 ...stress protein that is induced under some stress in endoplasmic reticulum ...of cAMP-dependent protein kinase and AAA+ family protein on osteoarthritis ...
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Hormone mediated down regulation of hepatic glutathione synthesis in the rat
... dibutyryl cAMP (DBcAMP), and glucagon inhibited GSH synthesis in cultured hepatocytes by ...Cellular cAMP levels exhibited a lower threshold for stimulation of the GSH efflux than inhibition of its ...and ...
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In vivo and in vitro models of demyelinating disease: activation of the adenylate cyclase system influences JHM virus expression in explanted rat oligodendrocytes.
... Chromatographic analysis of cAMP-dependent protein kinase activity in cytosol extracts prepared from astrocytes or oligodendrocytes revealed that both glial cell types were deficient in [r] ...
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Reduced Activity of Protein Kinase C in the Frontal Cortex of Subjects with Regressive Autism: Relationship with Developmental Abnormalities
... of cAMP-dependent protein kinase A (PKA) is de- creased in the frontal cortex of subjects with regres- sive autism as compared to age-matched control sub- jects and autistic subjects without ...
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Activating PRKACB somatic mutation in cortisol-producing adenomas
... of cAMP with the PepTag nonradioactive cAMP-dependent protein kinase assay (V5340, Promega) using kemptide, according to the manufacturer’s ...
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Counteracting Regulation of Chromatin Remodeling at a Fission Yeast cAMP Responsive Element-Related Recombination Hotspot by Stress-Activated Protein Kinase, cAMP-Dependent Kinase and Meiosis Regulators
... stress-activated protein kinase (SAPK) and the cAMP-dependent protein kinase (PKA) ...a cAMP responsive element (CRE)-like sequence at the site of the ade6-M26 mutation, ...
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In Vivo Activation of Protein Kinase A in Schizosaccharomyces pombe Requires Threonine Phosphorylation at Its Activation Loop and Is Dependent on PDK1
... Phosphoinositide-dependent protein kinase 1 (PDK1) plays a central role in cellular signaling by phos- phorylating members of the AGC family of ...includes protein kinase C (PKC), ...
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Intracellular signaling in the regulation of renal Na K ATPase I Role of cyclic AMP and phospholipase A2
... of cAMP-dependent protein kinase A (PKA), abolished the Na:K pump effect of all the cAMP agonists listed ...cell cAMP involves phospholipase A2 (PLA2), we used mepacrine, a PLA2 ...
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Regulation of the Subcellular Localization of Cyclic AMP-Dependent Protein Kinase in Response to Physiological Stresses and Sexual Differentiation in the Fission Yeast Schizosaccharomyces pombe
... (cAMP)-dependent protein kinase, also re- ferred to as protein kinase A (PKA), is a ubiquitous serine/ threonine kinase that functions in a variety of signal transduc- ...
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Drosophila G protein coupled receptor kinase 2 regulates cAMP dependent Hedgehog signaling
... Smo- dependent activation of downstream components of the signaling pathway was increased in the absence of ...cellular cAMP concentrations to a level that was limiting for Hh target gene ...stimulating ...
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Regulation of hormone sensitive calcium influx by the adenylyl cyclase system in renal epithelial cells
... for cAMP-dependent protein kinase with reduced affinity for cAMP and treatment with KT-5720, a specific cAMP-dependent protein kinase inhibitor, enhanced Ca ...
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Regulation of mRNA Export by Nutritional Status in Fission Yeast
... targets protein phosphatase 1 to its transcription factor substrates (Tu and Carlson ...the cAMP-phosphodiesterase of ...of cAMP-dependent protein kinase activity by a Dbcy1 ...
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PKA R1 spatially restricts Oskar expression for Drosophila embryonic patterning
... of cAMP-dependent protein kinase (Pka-R1) as a key factor in the restriction of Oskar protein to the posterior ...Oskar protein in developing Pka-R1 mutant oocytes, in which ...
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Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
... Prkar1a: protein kinase cAMP-dependent type I regulatory subunit alpha; PSA: prostate specific antigen; PSAP: presenilin-associated protein; PtdIns3P: phosphatidyl inositol 3-phosphate; ...
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Tong Luo Jiu Nao ameliorates Aβ1–40 induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
... surface protein receptors and intracellular signal transductions, including acetylcholine (Ach), glutamate (Glu), muscarinic acetylcho- line receptors (mAChR), N-methyl-D-aspartic acid (NMDA) receptors, ...
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Adeno-Associated Virus Type 2 Rep78 Inhibition of PKA and PRKX: Fine Mapping and Analysis of Mechanism
... the kinase activity of PKA and PRKX toward the artificial heptapeptide substrate referred to as kemptide (LRRASLG) ...fusion protein R1 inhibited PKA- and PRK-mediated phosphorylation of kemptide at levels ...
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