cAMP/PKA pathway
Original Article Aquaporins 1, 3 and 8 expression and cytokines in irritable bowel syndrome rats’ colon via cAMP-PKA pathway
... the cAMP-PKA pathway, but our study revealed that the cAMP-PKA pathway might be an important signaling pathway in the mechanism of ...the cAMP-PKA ...
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miR-155-5p Promotes Dorsal Root Ganglion Neuron Axonal Growth in an Inhibitory Microenvironment via the cAMP/PKA Pathway
... the cAMP/PKA pathway and in a TNF-α, IL-1β or MAG inhibitory microenvironment in ...the cAMP/PKA pathway and promote sensory conduction function recovery post dorsal column ...
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Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer
... Thirty-six mice received the implantation of CT26 car- cinoma tissue in their cecum. After general anesthesia and sterilization, a 2 cm vertical incision was made at the right lower quadrant of the abdomen. The cecum was ...
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Dynorphin regulates the phagocytic activity of splenic phagocytes in wall lizards: involvement of a κ opioid receptor coupled adenylate cyclase–cAMP–PKA pathway
... consequently, cAMP production (Lawrence and Bidlack, 1993; Sharp et ...intracellular cAMP upon the activation of opioid receptors is well established in mammalian immune cells (Aymerich et ...
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Activating PRKACB somatic mutation in cortisol-producing adenomas
... the cAMP/PKA pathway were found in 5 of 6 tumors including missense mutations in PDE8B (n = 1), GNAS (n = 2), PRKACA (n = 1), and PRKACB (n = ...
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The Heterotrimeric G-Protein GanB(α)-SfaD(β)-GpgA(γ) Is a Carbon Source Sensor Involved in Early cAMP-Dependent Germination in Aspergillus nidulans
... the cAMP/PKA pathway in response to ...response pathway whereas the Ga-subunit, Gpa1, plays a negative role by repressing Gbg (W hiteway et ...a cAMP cascade (W ang et ...
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The Genetic Architecture of Biofilm Formation in a Clinical Isolate of Saccharomyces cerevisiae
... the cAMP–PKA network—FLO8, SFL1, and MSN2—were found linked to colony biofilm for- mation in our QTL mapping ...the cAMP–PKA pathway we predicted that a Dflo8 mutant would exhibit a ...
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Histamine 1 receptor-Gβγ-cAMP/PKA-CFTR pathway mediates the histamine-induced resetting of the suprachiasmatic circadian clock
... the PKA blocker H89 suppress the H1R agonist-elicited Ca 2+ and Cl − responses in dissociated SCN ...in cAMP content in the SCN and this effect was precluded by co- applied gallein (100 μM) [one-way ANOVA: ...
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N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling
... via cAMP/ PKA ...or PKA inhibitor (H-89, 10 μM) added to the culture media 30 min prior to LPS and synaptamide treatment completely blocked synaptamide-derived sup- pression of TNF-α and iNOS ...
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Regulation of the Gα-cAMP/PKA signaling pathway in cellulose utilization of Chaetomium globosum
... protein-cAMP/ PKA pathway in the transcriptional regulation of cellu- ...the cAMP-dependent PKA, using an established RNA interference (RNAi) strategy [30, ...
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Dysfunctional Mitochondria Modulate cAMP-PKA Signaling and Filamentous and Invasive Growth of Saccharomyces cerevisiae
... the cAMP-PKA pathways. Our analysis indicates that the FG MAPK pathway is functional in rho cells and that the activity of the pathway is required for residual filamen- tation (Figures 3 and ...
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Role of tyrosine phosphorylation in sperm capacitation / acrosome reaction
... as cAMP, protein kinase A, receptor tyro- sine kinases, and non-receptor tyrosine ...involving cAMP/PKA, receptor tyro- sine kinases, and non-receptor protein tyrosine kinases have been ...of ...
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Protein Kinase A Contributes to the Negative Control of Snf1 Protein Kinase in Saccharomyces cerevisiae
... Snf1 pathway, we searched for mutations that, like snf1, suppress reg1 for the slow-growth ...known pathway components (SNF1, SNF4, and SAK1), we recovered “fast” mutations, designated fst1 and ...the ...
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The unsolved mystery of apoA-I recycling in adipocyte
... It is interesting to note that both apoA-I internalization and adipocyte lipolysis are stimulated by PKA activation. Multiple evidence suggested that cholesterol and trigly- ceride homeostasis were coupled in ...
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cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats
... The hippocampus was dissected out bilaterally, frozen in liquid nitrogen, homogenized in ice-cold radioimmunopre- cipitation assay (RIPA) lysis buffer and diluted with 0.1 N HCl to a final protein concentration of 1 ...
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Drosophila Costal1 Mutations Are Alleles of Protein Kinase A That Modulate Hedgehog Signaling
... whether pka-RII overexpression is suf- ficient to phenocopy Cos1 mutants, the GAL4-upstream activating sequence (UAS) system was used to overpro- duce RII in the developing ...of pka-RII (Park et ...
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Adeno-Associated Virus Type 2 Rep78 Inhibition of PKA and PRKX: Fine Mapping and Analysis of Mechanism
... the PKA fused to the amino terminus of glutathione S-transferase (GST) and a His tag, was cloned by ...PCR. PKA sequences were amplified using primers 5⬘-GCGAA GCTTATGGGCAACGCCGCCGCCGCC-3⬘ and ...
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The role of PKAc1 in gene regulation and trichodimerol production in Trichoderma reesei
... The cAMP pathway represents one of the most impor- tant signaling checkpoints in living organisms, with protein kinase A being a central component of the signal transmission ...messenger cAMP, this ...
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Reduced Activity of Protein Kinase C in the Frontal Cortex of Subjects with Regressive Autism: Relationship with Developmental Abnormalities
... Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein kinases are essential ...
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[HCO3-]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells
... Bicarbonate-regulated sAC represents an alternate source for cAMP [1-3,18]. sAC is not solely a soluble protein but is specifically targeted to well-defined intracellular com- partments – mitochondria, centrioles, ...
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