cAMP response element-binding
Adenosine A2Breceptors induce proliferation, invasion and activation of cAMP response element binding protein (CREB) in trophoblast cells
... intracellular cAMP [4,5,21]. cAMP is a secondary messenger involved in intracellular signal transduction, and also in the activation of protein ki- ...nases. cAMP-dependent protein kinase A (PKA) is ...
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Ghrelin through GHSR1a and OX1R heterodimers reveals a Gαs–cAMP cAMP response element binding protein signaling pathway in vitro
... of cAMP-response element luciferase reporter activity and cAMP ...s-cAMP-cAMP-responsive element signaling pathway in vitro and an increase in neuroblastoma cell ...
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The nuclear transportation routes of membrane-bound transcription factors
... regulatory element-binding protein (SREBP), plant bZIP TF family protein bZIP28 and several activating transcription factor (ATF)/cAMP response element-binding protein (CREB) ...
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Diet change and exercise enhance protein expression of CREB, CRTC 2 and lipolitic enzymes in adipocytes of obese mice
... The study investigated the effects of regular exercise and diet changes on the change in metabolic processes of the cAMP-Response Element-Binding Protein-Regulated Tran- scription Coactivator ...
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Abnormalities of T cell signaling in systemic lupus erythematosus
... Abbreviations AP1, activated protein 1; APC, antigen presenting cell; CAMKIV, calcium/ calmodulin-dependent kinase IV; CD40L, CD40 ligand; CREB, cAMP response element-binding; CREM, cAMP[r] ...
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Tong Luo Jiu Nao ameliorates Aβ1–40 induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
... Furthermore, although the precise aetiology of AD is still less well known, beta-amyloid peptide (Aβ) has been widely accepted as a crucial pathogenic factor in disease development [12-14]. Several lines of evidence ...
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Protein phosphatase 2A is a negative regulator of IL 2 production in patients with systemic lupus erythematosus
... phosphorylated cAMP response element–binding protein and its binding to the IL2 and c- fos promoters, as well as increased activator protein 1 activity, causing normalization of IL-2 ...
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Dietary potassium regulates vascular calcification and arterial stiffness
... Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element–binding[r] ...
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Analysis of hepatic gene transcription in mice expressing insulin insensitive GSK3
... insulin response element) that can be regu- lated by several transcription factors such as members of the Forkhead (FOXO) family ...regulatory element binding protein 1c) and CBP ...
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Indication of nerve growth factor binding components from herbal extracts by HerboChip: a platform for drug screening on a chip
... cAMP response element binding protein phosphorylation PC 12 cells were starved for 5 h and then challenged with NGF and CM extract for 0, 2 or 5 ...anti-phospho-cAMP response ...
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Antidepressant like effects of acupuncture involved the ERK signaling pathway in rats
... (p)-ERK1/2, cAMP response element-binding protein (CREB), p-CREB and brain-derived neurotrophic factor (BDNF) in the hippocampus were examined using western ...
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Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target
... zipper; cAMP, cyclic AMP; CBP, CREB-binding protein; ChiP, chromatin immunoprecipitation; CRE, cAMP response element; CREB, cAMP response element binding ...
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Models of buffering of dosage imbalances in protein complexes
... with binding partners forming an oligomer ...the cAMP response element binding protein (CREB-binding protein or CBP) and the ac- tivator for thyroid hormone and retinoid ...
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Role of single nucleotide polymorphisms (SNPs) in common migraine
... CREB: cAMP response element binding; CREM: cAMP-responsive element modulator; CSD: Cortical spreading depression; CVD: Cardiovascular disease; DFFB: DNA fragmentation factor ...
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Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
... facilitate cAMP response element-binding protein (CREB)-mediated expression of brain-derived neurotrophic factor (BDNF) to foster neuronal survival and reduce ...
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MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction
... CREB: cAMP response element-binding protein; Crh : corticotropin releasing hormone gene; Dnmt: DNA methyl-transferases; ELS: early life stress; Fos: FBJ murine osteosarcoma; FRAP: fluorescence ...
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Transcriptional regulation of the thyrotropin releasing hormone gene by leptin and melanocortin signaling
... adaptive response is caused by a reduction in thyrotropin-releasing hormone (TRH) expression that can be reversed by the administration of ...DNA binding of the cAMP response element ...
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The cAMP response element modulator (CREM) regulates T 2 mediated inflammation
... pSTAT5 binding to the Il-4r promoter was significantly decreased ...the binding of pSTAT5 to the Il-4 promoter was decreased ...CREM binding to the Il-4 and the Il-13 promoter was strongly enhanced ...
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The Role of CREB in the Liver and Adipose Tissue
... There are other family members of CREB, which in addition to CREB are the activating transcription factor 1 (ATF1) and cAMP- responsive element modulator (CREM), and these two proteins can also mediate ...
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Lactobacillus paracasei and Lactobacillus plantarum strains downregulate proinflammatory genes in an ex vivo system of cultured human colonic mucosa
... In order to test the results obtained from the microarrays, differential expression of 10 relevant genes was checked by real-time qPCR from the mRNA samples used for the microarray assays. Random distribution of the ...
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