Cancer Stem Cells Targeting
Modulation of cell death pathways in cancer stem cells: Targeting histone demethylases
... in cancer cells. Wnt signaling is important to maintain cancer stem cell state in various cancers ...colon cancer cells with LSD1 oligoamine inhibitor SL111144 led to increases ...
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A novel double-targeted nondrug delivery system for targeting cancer stem cells
... killing cancer stem cells (CSCs), the conventional chemotherapy used for cancer treatment promotes the enrichment of CSCs, which are responsible for tumor growth, metastasis, and ...by ...
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NADH autofluorescence, a new metabolic biomarker for cancer stem cells : identification of Vitamin C and CAPE as natural products targeting “stemness”
... of cancer stem-like cells ...MCF7 cells to “metabolic fractionation” by flow cytometry, using fluorescent mitochondrial probes to detect PCG1 α activity, as well ROS and hydrogen-peroxide ...
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Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC
... lung cancer xenograft models [9] and delayed morbidity in lymphoid as well as certain epithelial tumors in vivo ...as cancer stem cells (CSCs) have been demonstrated to play a major role in ...
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A mitochondrial based oncology platform for targeting cancer stem cells (CSCs) : MITO ONC RX
... By targeting the mitochondrial enzymes OXCT1 and ACAT1, we also developed new mitochondrial inhibitors that interfere with ketone metabolism, by mimicking the structure of CoA [24], (Figures 5 and ...
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Lunasin is a novel therapeutic agent for targeting melanoma cancer stem cells
... SKMEL-28 cells did not show any decrease in proliferation in adherent culture when treated with a concentration range of 10 to 100 µM over three days when assayed using a standard 3-(4,5-dimethylthiazol- ...
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Targeting cancer stem cells: emerging role of Nanog transcription factor
... pluripotent stem cells results in tumor ...between cancer cells and their surround- ing stromal and immune cells; Nanog expression level in both cancer and stromal cells ...
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Overcoming the lack of expression of the sodium iodide symporter protein in anaplastic thyroid cancer stem cells by targeting the phosphatidyl inositol 3 kinase signaling pathway
... these cells to facilitate thyroid hormone production (Paroder-Belenitsky et ...thyroid cancer cells (Kogai et al. 2008). In addition, cancer stem cells (CSCs) are potential ...
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miR-1 inhibits the proliferation of breast cancer stem cells by targeting EVI-1
... The levels of miR-1 expression were significantly decreased in the 21 cases of human breast cancer compared to the matched adjacent normal tissue (Figure 1A). In contrast, EVI-1 mRNA expression was increased in ...
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Targeting the osteosarcoma cancer stem cell
... colon cancer chemoresistance [52-55]. Human and murine hematopoietic stem cells and neural stem and progenitor cells have increased ALDH activity compared to non-stem ...
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Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-angiotensin System
... GB cancer stem cells (CSCs) invariably cause local ...embryonic stem cell markers express components of the renin-angiotensin system and are associated with circulating ...
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Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An updated Review
... normal cells development of resistance ...both cells and animal models [435, ...drugs targeting cancer cell epigenetics potentiates chemotherapy effects in solid tumors [437, ...leukamia ...
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CD133 as a Biomarker of Thyroid Cancer Stem Cells
... thyroid cancer cell growth and ...thyroid cancer cells (Zhuravel et ...T cells (for example Vγ9Vδ2 T cells) by any agents which cause their agglomeration within cells can ...
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Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
... development, stem cell self-renewal, and postnatal tissue ...of cancer stem cells, tumor angiogenesis, and epithelial- to-mesenchymal transition (EMT) have been ...in cancer ...
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Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression
... of cancer progression and is capable of fostering growth and progression of early lesions to PDAC and into metastatic ...pancreatic cancer both in vitro and in vivo; however, those studies have not been ...
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Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis
... of cells where not all the disseminated cancer cells have the prerogative and “in-build genetic cues” to form secondary ...tumors. Cells with stem like properties complemented by key ...
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<p>Targeting stem cells in the realm of drug-resistant breast cancer</p>
... that cancer cells have aberrant cell cycle machin- ery that aids them to divide and proliferate ...these cancer cells might provide a way to overcome the resistance in cancer ...
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Molecular identification and targeting of colorectal cancer stem cells
... glioma-initiating cells (GICs) were generated by overexpressing SV40 Large T antigen and oncogenic Ras in neural mouse stem ...these cells were genetically modified to carry the DTA gene by a ...
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Targeting epithelial-mesenchymal transition and cancer stem cells for chemoresistant ovarian cancer
... preferentially targeting CSCs are also useful in reversing ...tumor cells, and most importantly, VS-5584 was also able to significantly repress tumor regrowth after chemotherapy in an immunodeficient OC ...
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Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations
... target cells. From 0 to 24 hours, verapamil-resistant cells (VRCs) were cultured as adherent cells in the E-plate (96 wells) in groups 1 and 3–6, while group 2 had DCs and CTLs ...hours, cells ...
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