cancer stemness
Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline
... Epidemiological analysis has demonstrated the majority of OSCC arise in Southeast Asia are due to areca nut chewing together with tobacco smoking [18]. Nevertheless, the pathogenetic roles of areca nut in OSCC have not ...
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Suppression of miR-204 enables oral squamous cell carcinomas to promote cancer stemness, EMT traits, and lymph node metastasis
... breast cancer [15], gastric cancer [16], colorectal cancer [17], papillary thyroid ...ability, stemness markers (SOX2, NANOG, KLF4, OCT4, and CD133) expression, invasiveness, and in vivo ...
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<p>ZGRF1 Is Associated with Poor Prognosis in Triple-Negative Breast Cancer and Promotes Cancer Stemness Based on Bioinformatics</p>
... current cancer therapies fail to repress tumor recur- rence and metastasis in TNBC because they fail to target cells that possess epithelial – mesenchymal (E-M) plasticity and acquire cancer stem cell (CSC) ...
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STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells
... cells stemness and enhanced 5-FU sensitivity in HCC ...cells stemness and 5-FU sensitivity were rescued by RhoA or YAP-5SA ...suppressing cancer stemness in hepatocellular carcinoma cells via ...
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<p>PTPRU, As A Tumor Suppressor, Inhibits Cancer Stemness By Attenuating Hippo/YAP Signaling Pathway</p>
... PTPRU belongs to the protein tyrosine phosphatase (PTP) family 11–13 that regulates a variety of important cellular processes. 14,15 The role of PTPRU in tumor progression is contradictory. 17 PTPRU has been reported to ...
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Aspirin mediates histone methylation that inhibits inflammation-related stemness gene expression to diminish cancer stemness via COX-independent manner
... of cancer cells that possess the ability to self-renew, differ- entiate, and modulate cancer growth, recurrence, metas- tasis, and chemo-resistance [3, 8, 37, ...of cancer cell stemness ...
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BORIS: a key regulator of cancer stemness
... in cancer metastasis ...for cancer stemness ...breast cancer cells gathered from bone marrow of breast cancer ...some cancer stem cell characteristics and EMT like invasive ...
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<p>CARF, As An Oncogene, Promotes Colorectal Cancer Stemness By Activating ERBB Signaling Pathway</p>
... colorectal cancer stemness, we performed bioin- formatic analysis and found that the expression of CARF is positively correlated with MAPK8 and JUN (Figure 4A – C), the most important factors in ERBB sig- ...
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AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer
... drives stemness or whether it is a passenger, we assessed the spheroid-forming capacity of cells overexpressing edited ...in cancer tissues (16, ...driving cancer stemness in ...
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<p>miR-520b Promotes Breast Cancer Stemness Through Hippo/YAP Signaling Pathway</p>
... formation activities of breast cancer cells. As shown in Figure 2A, we found that miR-520b overexpression signi fi - cantly increased the diameter and the number of the spheres, which demonstrated that miR-520b ...
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Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness
... deacetylase, potentially regulates the acetylation of transcription factor p53 [33–35]. SIRT1 has been implicated in the maintenance of pluripotency in various types of stem cells [36–39]. Interestingly, SIRT1 has also ...
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KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers
... glioma stemness [47] beyond gliomagenesis [48] and to correlate with histological grade ...glioma stemness, leading to cancer progression and therapeutic ...and cancer stemness or the ...
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Stemness and plasticity of lung cancer cells: paving the road for better therapy
... of cancer stem cell biology in lung cancer is essential to develop effective ...dynamic cancer cell phenotype that can interconvert from a pure non-CSC phenotype to a pure CSC phenotype in ...
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Honokiol inhibits bladder tumor growth by suppressing EZH2/ miR-143 axis
... bladder cancer (UBC) cells have not yet fully ...survival, cancer stemness, migration, and invasion, through downregulation of EZH2 expression level, along with the reductions of MMP9, CD44, Sox2 and ...
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miRNA-regulated delivery of lincRNA-p21 suppresses -catenin signaling and tumorigenicity of colorectal cancer stem cells
... The precise molecular mechanisms underlying the self-renewing capacity of CSCs remain largely unclear [2]. We herein uncover a novel role of lincRNA-p21 in repression of stem-like phenotypes in CRC cells. Previous ...
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Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells
... intestinal stem cell signature was able to predict disease relapse in colorectal cancer patients. In the study, another Wnt target gene, the receptor tyrosine kinase EphB2 (ephrin type-B receptor 2), was used to ...
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Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
... whether cancer stem cell characteristics may influence sorafenib resistance, CD133 (+) and (−) cells were treated with various concentrations of sorafenib ...
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<p>Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro</p>
... The analytical determination and validation of the concentra- tions of MVS-GNPs (1 µ g/mL) against cancer and normal cell suspensions were conducted with statistical analytical techniques. The absorbance was ...
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LncRNA XIST/miR-200c regulates the stemness properties and tumourigenicity of human bladder cancer stem cell-like cells
... bladder cancer cells and the epithelial-to-mesenchymal transition ...promotes cancer progression and might act as an miRNA molecular ...the stemness properties and tumourigenicity of human bladder ...
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IL-8 regulates the stemness properties of cancer stem cells in the small-cell lung cancer cell line H446
... the stemness property of CSCs in the H446 cell line, we used the RNA interference technology to silence IL-8 expression in the tumor spheres and verified the IL-8 expression by qRT-PCR and ...
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