Cancer--Susceptibility
Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk
... Two haplotypes of CHEK2, both carrying the minor allele of CHEK2-14 (rs9608698), showed potential associations but with risks in opposing directions. These were evaluated further by generating haplotypes from the SNP ...
14
Search for new breast cancer susceptibility genes
... breast cancer family ...the cancer risk conferred by an as yet unknown gene (or ...the cancer occurrence in the families described here, this gene is expected to cause breast cancer risks ...
196
Reduction in breast cancer susceptibility due to <em>XbaI</em> gene polymorphism of alpha estrogen receptor gene in Jordanians
... Breast cancer is a global health concern among women ...breast cancer and 142 healthy Jordanian women were enrolled in this case–control ...breast cancer risk within the “x” allele of heterozygotes ...
5
Undefined familial colorectal cancer and the role of pleiotropism in cancer susceptibility genes.
... colorectal cancer (CRC) a genetic diagnosis cannot be obtained in over 50 % of familial cases when screened for known CRC cancer susceptibility ...in susceptibility genes for other ...non-CRC ...
7
Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21
... multicancer susceptibility region reported by GWAS for bladder cancer, breast cancer, chronic lymphocytic leukemia, glioma, lung cancer, melanoma, non-melanoma skin cancer, ovarian ...
16
Clustering of sebaceous gland carcinoma, papillary thyroid carcinoma and breast cancer in a woman as a new cancer susceptibility disorder: a case report
... thyroid cancer, but her lack of hamartomatous polyps and the presence of a sebaceous carcinoma cannot be readily explained in the framework of this ...a cancer strongly linked with radiation exposure to the ...
6
Gene-gene interactions in gastrointestinal cancer susceptibility
... with susceptibility to gastrointestinal cancers, such as colorectal (colon, rectal or both), gastric (stomach) and esophageal (gullet) ...between cancer-associated genes, (ii) interactions between ...
14
Review Article Lack of association between LCT-13910 C/T (rs4988235) polymorphism and risk of colorectal cancer: evidence from case-control studies
... colorectal cancer risks, due to the small sample ...colorectal cancer, the present meta-analysis was ...colorectal cancer patients and 2,230 controls, aiming to verify the association between ...
7
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.
... rs1469713/19p13 breast, ovarian, and prostate cancer susceptibility locus. The black dots represent all variants nominally associated (P < 0.05) with every cancer type individually that had the ...
39
RNase L Variants Do Not Appear to Impact on Clinical Features of Sporadic Prostate Cancer Patients
... Prostate cancer is the most common non-cutaneous male cancers, contributing to significant mortality rates ...prostate cancer patients, including one linked with general cancer susceptibility ...
6
Plasma proteomic and autoantibody profiles reveal the proteomic characteristics involved in longevity families in Bama, China
... to cancer: CASC4 is a cancer susceptibility candidate, reduction of the expression of CASC4 has been shown to suppress the proliferation of gastric cancer [59]; tumor protein D52- like 1 ...
12
Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
... inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch re- pair (MMR) genes: MLH1, ...
6
The precision relationships between eight GWAS-identified genetic variants and breast cancer in a Chinese population
... breast cancer susceptibility loci discovered in recent Genome-wide association studies (GWASs) have not been confirmed in Chinese ...breast cancer risk in women from southeast China, we conducted a ...
11
Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population
... the cancer susceptibility region located at ...gastric cancer (GC) risk with a case-control study in a Chinese Han ...GC susceptibility in the Chinese Han ...
6
The genetics of susceptibility to breast cancer
... ovarian cancer families exam ined for disease linkage to BRC A l h ad been prev io u sly g enotyped w ith m icrosatellite m arkers spanning the B RC A l gene and adjacent regions on chrom osom e 17q (Dr ...ovarian ...
302
Association of an NFKB1 intron SNP (rs4648068) with gastric cancer patients in the Han Chinese population
... gastric cancer and the promoter region of NFKB1 [9,10] and many reports also showed that the genetic variations in introns might involve alternative gene regulation, tran- script processing, or chromosomal ...
7
Characterization of ovarian clear cell carcinoma using target drug-based molecular biomarkers: implications for personalized cancer therapy
... breast cancer susceptibility gene 1 (BRCA1), breast cancer susceptibility gene 2 (BRCA2) and programmed death-ligand 1 (PD-L1) were measured in 96 ovarian CCC and 113 HGSC by ...
12
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population
... lung cancer (LC) susceptibility in a cancer genome- wide association study (GWAS) Here, we assessed whether seven previously reported RTEL1 polymorphisms influenced LC risk in Han Chinese ...696 ...
6
Quantitative assessment of the clinical susceptibility of calcium-sensing receptor polymorphisms in cancer patients
... in cancer risk with unknown clinical significance and ...and cancer risk reported until April ...and cancer risk in any of the genetic models in overall ...
9
Effect of genetic ancestry to the risk of susceptibility to gastric cancer in a mixed population of the Brazilian Amazon
... gastric cancer in the European popula- tion may be related to lower frequency of alleles related to high susceptibility of developing gastric cancer [5, ...gastric cancer in the studied Amazon ...
5