cancer/testis antigen
Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E
... Cancer-testis antigen MAGE-C2 is normally expressed in testis but aberrantly expressed in various kinds of tumors. Its functions in tumor cells are mostly unknown. Here, we show that MAGE-C2 ...
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Cancer testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma
... a cancer- testis antigen, SLLP1 RNA was also present in normal testis tissue but, importantly, it was absent from the whole BM of 11 healthy donors analyzed (Figure 1a) thus indicating a ...
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Cancer testis antigen and immunotherapy
... a cancer vaccine is dependent on the ability of a patient to mount a primary or memory immune response against cancer antigens used in the ...of cancer vaccine studies have focused on patients with ...
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Molecular Expression Analysis of Restrictive Receptor for Interleukin 13, a Brain Tumor-associated Cancer/Testis Antigen
... (Fig. 4, panels I, II, and IV). The presence of the transcripts within the CNS was most evident, as was the case for IL13R , in medulla, spinal cord, substantia nigra and thalamus (blot # 7775-1, dots 2-G, 3-E, 3-A, 3-C ...
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Original Article Expression status and prognostic value of cancer/testis antigen OY-TES-1 in glioma
... Our result suggested that preparing OY-TES-1 antigen-related tumor vaccine might enhance therapy effect of glioma in future. However, from the view point of our research or pertinent published literatures, this ...
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Prevalence of plasma autoantibody against cancer testis antigen NY ESO 1 in HTLV 1 infected individuals with different clinical status
... The data directly demonstrate the presence of autoreac- tive antibodies against CT antigen NY-ESO-1 in the peripheral blood of HTLV-1-infected individuals, irre- spective of clinical status. Since NY-ESO-1 is one ...
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Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy
... in antigen processing, such as downregulation of Transporter Associated with Antigen Processing 1 (TAP1) expression, have been reported in a variety of different cancer types and have been shown to ...
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Establishment of cancer/testis antigen profiling based on clinicopathological characteristics in resected pathological stage III non-small cell lung cancer
... EGFR tyrosine kinase inhibitors were demonstrated to greatly improve the disease-free survival of resected stage II–IIIA EGFR-mutant lung cancer patients. In our study, we also evalu- ated the association between ...
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Original Article Down-regulation of cancer/testis antigen OY-TES-1 attenuates malignant behaviors of hepatocellular carcinoma cells in vitro
... liver cancer cell lines available to us (Figure 1A), we could not perform the functional an- alysis of OY-TES-1 gene by transfecting it into OY-TES-1 negative liver cancer cell ...
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Original Article Cancer testis antigen OY-TES-1 expression and serum immunogenicity in colorectal cancer: its relationship to clinicopathological parameters
... OY-TES-1 coding sequence from nucleotides 28 to 1723 was amplified from human testis cDNA by PCR with Primers (sense: 5’-GCGGGCGGAT- CTTCTCCGGCCATG-3’; antisense: 5’-ACGGGA- TCCTTATCAGTTGGGCTGGGGTGT-3’). PCR prod- ...
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Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration
... CT-X antigen SAGE (CT14) and the D-E-A-D box containing protein DDX26 ...ovarian cancer and multiple myeloma, CT45 is expressed in a larger number of cases ...
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CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers
... the cancer cells, which generally come from epithelial cells, to become more motile and aggres- ...successful cancer treatment, since without metastasis, most solid organ cancers would not be fatal ...
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Review Article Colon adenocarcinoma prognosis by BORIS a cancer-testis antigen
... Ovarian Cancer Study Group, Williams RT, Flemming C, Lambrechts D, Despierre E, Lambrechts S, Vergote I, Kar- lan B, Lester J, Orsulic S, Walsh C, Fasching P, Beckmann MW, Ekici AB, Hein A, Matsuo K, Hosono S, ...
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Cancer/Testis Antigens and Colorectal Cancer
... The cancer/testis antigen (CTA) genes have attracted a great deal of interest; particularly in the field of oncology and tumour immunology ...termed testis/brain-restricted and ...
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Complete Remission Following Decitabine/Dendritic Cell Vaccine for Relapsed Neuroblastoma
... upregulate cancer testis antigen expression, followed by a dendritic cell vaccine targeting the cancer testis antigens MAGE- A1, MAGE-A3, and ...tumor antigen expression followed ...
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Cancer/testis antigens (CTAs) expression in resected lung cancer
... Results: High expression of MAGEA1 (16.7% vs 65.0%, P=0.004), MAGEA10 (61.1% vs 95.0%, P=0.016), MAGEB2 (55.6% vs 95.0%, P=0.007), and KK-LC-1 (16.7% vs 55.0%, P=0.020) was closely correlated with lymph node metastasis ...
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MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells
... tumor antigen that is physiologically expressed in the germ cells of the testes as well as in a variety of malignant tumors but not in normal tissues ...for cancer immunotherapy [17, ...novel cancer ...
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Association of serum follistatin levels with histological types and progression of tumor in human lung cancer
... gonadal cancer, gastric cancer, hepatocellular carcinoma, basal cell carci- noma, and melanoma ...lung cancer patients with different histological types, TNM staging, tumor progression, and ...
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Inducible expression of cancer-testis antigens in human prostate cancer
... To evaluate the translational relevance of these findings, we developed a novel approach to test EMAs in human cancer with an ex vivo tissue culture with human PC specimens. Similar drug cultures were used by ...
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Diagnostic value of serum cancer antigen 125 in ovarian cancer patients
... ovarian cancer, CA 125 levels were found to correlate with tumor burden in 93% of cases (Drescher, ...ovarian cancer in the general population and the risk of a false-positive ...ovarian cancer was ...
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