Cancer/testis antigen (CTA)
Cancer testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma
... a cancer- testis antigen, SLLP1 RNA was also present in normal testis tissue but, importantly, it was absent from the whole BM of 11 healthy donors analyzed (Figure 1a) thus indicating a ...
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Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E
... Cancer-testis antigen MAGE-C2 is normally expressed in testis but aberrantly expressed in various kinds of tumors. Its functions in tumor cells are mostly unknown. Here, we show that MAGE-C2 ...
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Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy
... chimeric antigen receptors, have been reported [16, 17, 36, 45- ...of CTA directed vaccination, an HMA and a checkpoint inhibitor might be an attractive approach for patients with AML ...
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CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers
... differentiation, CTA expres- sion is actually highest in the most differentiated cells, the sperm cell, which has lost its ability to proliferate ...that CTA expression is often times actually lost in ...
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Establishment of cancer/testis antigen profiling based on clinicopathological characteristics in resected pathological stage III non-small cell lung cancer
... (47.5%). CTA expression was histology dependent, and concurrent expression was ...4 CTA combination covered ...2 CTA combination in patients with features of male sex, positive smoking history, and ...
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Prevalence of plasma autoantibody against cancer testis antigen NY ESO 1 in HTLV 1 infected individuals with different clinical status
... Additional file 1: Figure S1. Preparation of His-NY-ESO-1 recombinant protein a. Sequence of NY-ESO-1 gene (NCBI Reference Sequence: NC_000023.11). b. Scheme of construction of pET-14b-NY-ESO-1 plasmid. The full-length ...
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Review Article Colon adenocarcinoma prognosis by BORIS a cancer-testis antigen
... It is worth mentioning that this is the first time investigating the prognosis of BORIS expres- sion in colorectal cancer. In addition, for 3-year overall survival rate, we also found that high BORIS expression ...
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Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration
... CT-X antigen SAGE (CT14) and the D-E-A-D box containing protein DDX26 ...ovarian cancer and multiple myeloma, CT45 is expressed in a larger number of cases ...
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Cancer testis antigen and immunotherapy
... a cancer vaccine is dependent on the ability of a patient to mount a primary or memory immune response against cancer antigens used in the ...of cancer vaccine studies have focused on patients with ...
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Original Article Expression status and prognostic value of cancer/testis antigen OY-TES-1 in glioma
... tate cancer cell lines, lung cancer cell lines and breast cancer cell lines were also certified expressing OY-TES-1 ...ovarian cancer and found its positive rate of protein expression was much ...
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Cancer/Testis Antigens and Colorectal Cancer
... The cancer/testis antigen (CTA) genes have attracted a great deal of interest; particularly in the field of oncology and tumour immunology ...fide’ CTA genes have expression restricted ...
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Original Article Cancer testis antigen OY-TES-1 expression and serum immunogenicity in colorectal cancer: its relationship to clinicopathological parameters
... ther study revealed that although NY-ESO-1 mRNA was detected in both pancreas and liver, no corresponding protein has ever been report- ed in these tissues analyzed by immunohisto- chemistry [4]. Therefore, we speculates ...
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Molecular Expression Analysis of Restrictive Receptor for Interleukin 13, a Brain Tumor-associated Cancer/Testis Antigen
... The search of the SEREX database (www.licr.org, University of Saarland, Hom- burg, Germany) failed to match IL13R with any known SEREX or testis/cancer antigen. This may be due to several reasons. ...
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Complete Remission Following Decitabine/Dendritic Cell Vaccine for Relapsed Neuroblastoma
... upregulate cancer testis antigen expression, followed by a dendritic cell vaccine targeting the cancer testis antigens MAGE- A1, MAGE-A3, and ...tumor antigen expression followed ...
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Diagnostic value of serum cancer antigen 125 in ovarian cancer patients
... of cancer cells (National Comprehensive Cancer Network, ...and cancer antigen ...ovarian cancer types, used in staging and also in predicting the prognosis (Jyothi Kancherla et ...
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Association of serum follistatin levels with histological types and progression of tumor in human lung cancer
... lung cancer from the healthy subjects and benign lung ...lung cancer but also might be associated with the disease progression and metastasis of lung ...
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MECHANICAL PROPERTIES OF PLASTICIZED CELLULOSE ESTER FILMS AT ROOM AND HIGH TEMPERATURES
... plasticized CTA and CAP films were prepared using a solution cast method since melt processing is not applicable for CTA due to its severe thermal degradation (Ohkita et ...and CTA/TCP are optically ...
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... nize a single epitope and therefore, the use of MAbs re- sults in a higher specifi city of the detecting method but at the costs of lower sensitivity. Polyclonal antibodies (PAb) show higher sensitivity because of the ...
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Inducible expression of cancer-testis antigens in human prostate cancer
... of cancer therapies as preclinical data has demonstrated potent and wide-ranging anti-tumor effects when administered in low, biological ...enhance CTA expression and even restore it in epigenetically ...
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Cancer/testis antigens (CTAs) expression in resected lung cancer
... shows cancer/testis antigens (CTAs) play a key role in ...lung cancer at the mRNA level. Methods: Thirty-eight surgical lung cancer samples were ...The Cancer Genome Atlas ...
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