Cannabinoid CB1 receptor antagonist
Interaction Between L-Type Calcium Channels and Antagonist of Cannabinoid System on Anxiety in Male Rat
... doses CB1 receptor agonists elicits anxiolytic- like effects in avoidance tasks (12, 35, ...and CB1 receptor agonists would result in euphoria, relaxation, heightened perception, sociability, ...
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Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant
... the CB1 receptor antagonist rimonabant are con- sidered to act principally by reducing appetite and/or increasing satiety, thereby producing reduced energy in- take ...
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Interaction between Antagonist of Cannabinoid Receptor and Antagonist of Adrenergic Receptor on Anxiety in Male Rat
... and CB1 receptors are particularly well-rep- resented in the cortex (entorhinal and cingulate), hip- pocampus, lateral septum, nucleus accumbens, amyg- dala and Peri-Aaqueductal Gray area (PAG) (Millan, ...2003). ...
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Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis
... R antagonist AM6545 was pharmacologically character- ized earlier (32), and its antifibrotic efficacy was recently shown on prevention of radiation-induced PF ...
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Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie
... of CB1 on glutamatergic neurons eases the behavioural flexibility to relearn or learn a new platform ...the CB1 antagonist AM251 alleviated perseverance in a set-shifting task in rats (Hill et ...of ...
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The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice
... the cannabinoid CB 1 recep- tor antagonist/inverse agonist AM 251 decreased Met ...of cannabinoid re- ceptor ligands with different intrinsic activities and ...1 receptor agonist ...
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Cannabinoid CB1 Transmission in the Mesolimbic Reward Pathway
... κ-opiate receptor transmission within the VTA in the mediation of opiate-related aversion (Margolis et ...intra-PLC CB1 activation to induce morphine-related place aversion was dependent upon a KOR ...
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
... (46) (a)Trudell, M. L.; Izenwasser, S. (eds). Dopamine Transporters: Chemistry, Biology and Pharmacology. Wiley Interscience: New York, 2008. (b) Lange, Jos H.M.; Kruse, Chris G. Medicinal chemistry strategies to ...
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Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
... [23]. CB1 expression appears to increase with differentiation, an observation that has also been made in embryonic corti- cal development ...that CB1 is expressed by cells that are primarily affected by ...
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<p>Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats</p>
... the cannabinoid receptor antagonist (AM 251) on the CCI-induced neuropathic pain revealed no signi fi cant change compared to the vehicle ...(CB1 receptor inverse agonist) not only ...
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Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism
... of antagonist 9 forms a tight and slowly dissociating ligand-receptor ...the antagonist 9 enjoys a binding ‘‘mono- poly” to hCB1 receptors and the occupied hCB1 receptors are pseudo-irreversibly ...
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Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation
... endo- cannabinoid system consists of two G protein-coupled receptors known as cannabinoid receptors CB1 and CB2; their endogenous ligands, the endocannabinoids, derived from lipid precursors; and the ...
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Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells
... receptor can physically interact with GPR55 and modulate each other signaling properties ...CB2 antagonist SR144528 did not affect glioma cells proliferation in the same experimental conditions used for ...
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PubMedCentral-PMC4905821.pdf
... the CB1 antagonist/inverse agonist AM-251 suggested increased sensitivity to cannabinoid modulation in adolescent as compared to adult mice, with all doses tested (1, 3 and 10 mg/kg) reducing alcohol ...
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The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: Implications in neurological disorders
... The transfer of HINT1 from MORs to NMDARs results in the impairment of their cross-regulation, i.e., the activation of MORs does not recruit NMDAR activity, and that of the NMDAR does not impair MOR-mediated effects, ...
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Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
... nucleus; mGluR1: Metabotropic glutamate receptor type 1; ML: Molecular layer; N.S.: No significant; NBF: Neutral buffered formalin; ND: Not Determined; P: Postnatal day; PBS: Phosphate buffered saline; PCL: ...
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The effect of cannabinoids on IL 1beta induced catabolic pathways in osteoathritic chondrocytes
... and CB1 receptor agonist CP55,940 inhibited IL-1 p induced secretion of IL-6 and IL-8 in RA fibroblast like synovial cells, suggesting an anti-inflammatory activity of cannabinoids (Selvi et al, 2008) and ...
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Anti inflammatory effects of N acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX 2 dependent manner
... Methods: Immunofluorescence and western blotting were used to detect cannabinoid receptors and related enzymes. Cytokines and MMP-3 were measured by ELISA. Intracellular signaling proteins were detected by ...
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Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
... doses (intraperitoneal administration; Figure 6) antagonized all the effects produced by the cannabinoid agonist WIN 55,212-2 (1.5 mg/kg), the difference being statistically significant for rectal temperature, ...
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Pharmacodynamics of cannabinoids
... various cannabinoid-type components called cannabinoids (presently estimated at about ...endogenous cannabinoid receptor ligands were of high signi ...“agonistic” receptor activity were ...
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