Cannabinoid Receptor
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
... - SD) is shown (n = 3 for each condition). ANOVA revealed significant between-group differences (control versus IFN- γ (50 U/ mL) and IFN- γ (50 U/mL) versus IFN- γ (100 U/mL); p < 0.005). C, Western immunoblot ...
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The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health
... the cannabinoid receptor type 1 in the differentiation and survival of ...the cannabinoid receptor type 1 has a prosurvival function during acute cell ...the cannabinoid system in ...
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Activation of cannabinoid receptor CB2 regulates LPS induced pro inflammatory cytokine production and osteoclastogenic gene expression in human periodontal ligament cells
... thetic cannabinoid agonists, and plays important modu- latory functions in the brain and also in the periphery ...the cannabinoid receptor CB2, which is ex- pressed by a wide range of immune cells ...
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Interaction between Antagonist of Cannabinoid Receptor and Antagonist of Adrenergic Receptor on Anxiety in Male Rat
... 2003). Cannabinoid receptor agonists/antagonists have been shown to exert anxiolytic effects in some studies (Saito,Wotjak & Moreira 2010) but anxiogenic effects in the others (Carvalho et ...CB1 ...
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Cannabinoid receptor signaling regulates liver development and metabolism
... of cannabinoid receptor (Cnr) activity disrupts liver development and metabolic function in zebrafish (Danio rerio), impacting hepatic differentiation, but not endodermal specification: loss of ...
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The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11.
... hematopoietic receptor (39), which may be involved in monocyte/macrophage differentiation (40), we decided to determine the nucleotide sequence and genomic structure of ...Cnr2 receptor is present within ...
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Hepatitis C virus induces the cannabinoid receptor 1
... quantitated by densitometry using Image J software (ImageJ, NIH, Bethesda USA [29]), with values normalised to the loading control dye (Amido Black). For immunohistochemistry, formalin fixed, paraffin embedded 4 m ...
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The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
... CB1 cannabinoid receptor agonist on L-DOPA-stimulated abnormal behavioral and signaling responses in ...CB1 cannabinoid receptor agonist WIN-55,212-2 had no effect on L-DOPA-induced motor ...
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Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study
... A limitation of our study is the lack of measurement of placental anandamide levels and NAPE-PLD expres- sion. Furthermore, our study had a case–control design, thus direct causation cannot be determined. Neverthe- less, ...
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Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
... Peripheral blood mononuclear cells from healthy donors were collected using Ficoll-Conray (Imuuno-Biological Laboratories, Gunma, Japan) gradient centrifugation. Positive selection of CD14 + monocytes was performed using ...
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Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie
... Hippocampal electroencephalographic activity was recorded in the dentate gyrus granule cell layer. Surgery and positioning of the recording electrode was accomplished as described above. For EEG experiments, mice were ...
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Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis
... the cannabinoid 1/cannabinoid 2 receptor agonist WIN 55212-2 was only able to attenuate leukocyte-endothelial interactions in the cerebral micro- circulation if given at a higher dosage (10 mg/kg) ...
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Chronic, intermittent treatment with a cannabinoid receptor agonist impairs recognition memory and brain network functional connectivity
... chronic cannabinoid exposure upon brain and synaptic function opens a window into the development of therapeutic tools that could counteract the “on target” side-effects associated with chronic use of cannabis and ...
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Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis
... CB2 receptor status and its activation to- ward alcohol-mediated liver injury was further underscored by showing that mice fed an alcoholic liquid diet contain- ing ...
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
... this receptor has not been examined at all in relation to diabetic ...this receptor induces a strong response towards insulin release in mice, and has been shown to increase both glucose tolerance and ...
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Synthesis of Amphibian Alkaloids and Synthesis and Affinity of Novel Cannabinoid Receptor Ligands
... acetylcholine receptor has become the target in understanding various health consequences involved in smoking and its mechanisms of ...Nicotinic receptor ion channels are also opened by ...acetylcholine ...
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Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
... The CB1R (encoded by CNR1) was first identified in 1990 as a target of D 9 -tetrahydrocannabi- nol (THC), the putative psychoactive constituent substance in the Cannabis plant [19]. Three years later the cannabinoid ...
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<p>Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats</p>
... the cannabinoid receptor antagonist (AM 251) on the CCI-induced neuropathic pain revealed no signi fi cant change compared to the vehicle ...(CB1 receptor inverse agonist) not only decreased the ...
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Interaction Between L-Type Calcium Channels and Antagonist of Cannabinoid System on Anxiety in Male Rat
... and cannabinoid CB1 receptors are particularly well-represented in the cortex (entorhinal and cingulate), hippocampus, lateral septum, nucleus accumbens, amygdala, and peri-aqueductal gray area (PAG) ...(2). ...
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Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis
... endocannabinoid/cannabinoid receptor 1 (endocannabinoid/CB 1 R) system is another rational ther- apeutic target in ...on cannabinoid receptors, CB 1 R and CB 2 R, that also recognize and mediate the ...
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